2022 - Research.com Biology and Biochemistry in Japan Leader Award
The scientist’s investigation covers issues in Cell biology, Immunology, Molecular biology, SOCS3 and Cancer research. His research on Cell biology focuses in particular on Signal transduction. His work deals with themes such as SH2 domain, Receptor tyrosine kinase, Janus kinase 2, Phosphorylation and Leukemia inhibitory factor, which intersect with Molecular biology.
Leptin receptor is closely connected to Endocrinology in his research, which is encompassed under the umbrella topic of SOCS3. His Cancer research course of study focuses on Janus kinase and JAK-STAT signaling pathway and Kinase activity. The Cytokine study combines topics in areas such as Proinflammatory cytokine, Inflammation, Colitis and T cell.
Akihiko Yoshimura mainly investigates Cell biology, Immunology, Cytokine, Molecular biology and Cancer research. Akihiko Yoshimura combines subjects such as Receptor and FOXP3 with his study of Cell biology. His study in Immunology focuses on Inflammation, Immune system, T cell, Interleukin 17 and Autoimmunity.
His research in Cytokine intersects with topics in Tumor necrosis factor alpha, Cellular differentiation, Suppressor of cytokine signaling 1, STAT1 and Proinflammatory cytokine. His Molecular biology research incorporates elements of SH2 domain and Pleckstrin homology domain. His SOCS3 research includes elements of Endocrinology and STAT protein.
His primary areas of investigation include Immunology, Cell biology, Immune system, Inflammation and Cancer research. His Immunology research includes themes of Lung and Mycobacterium tuberculosis. His studies deal with areas such as Cellular differentiation, Cytokine, Transcription factor, Epigenetics and FOXP3 as well as Cell biology.
His research on Cytokine also deals with topics like
His scientific interests lie mostly in Immunology, Cell biology, FOXP3, Immune system and Genetics. His Immunology research is multidisciplinary, incorporating perspectives in Cancer research, Internal medicine and Drug. His study involves Janus kinase and SOCS3, a branch of Cell biology.
His study looks at the intersection of Janus kinase and topics like Innate immune system with Suppressor of cytokine signaling 1. Akihiko Yoshimura has included themes like Regulatory T cell, Interleukin 12, Antigen and DNA methylation in his FOXP3 study. The Immune system study combines topics in areas such as Liver disease, Primary sclerosing cholangitis and Ulcerative colitis.
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A new protein containing an SH2 domain that inhibits JAK kinases
Takaho A. Endo;Masaaki Masuhara;Masahiro Yokouchi;Ritsu Suzuki.
SOCS proteins, cytokine signalling and immune regulation.
Akihiko Yoshimura;Tetsuji Naka;Masato Kubo.
Nature Reviews Immunology (2007)
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang.
Nature Immunology (2006)
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Akihiko Yoshimura;Tadashi Ohkubo;Toru Kiguchi;Nancy A. Jenkins.
The EMBO Journal (1995)
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
Hideo Yasukawa;Hiroyuki Misawa;Hiroshi Sakamoto;Masaaki Masuhara.
The EMBO Journal (1999)
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Seiji Okada;Masaya Nakamura;Hiroyuki Katoh;Tamaki Miyao.
Nature Medicine (2006)
Regulation of cytokine signaling and inflammation
Toshitkatsu Hanada;Akihiko Yoshimura.
Cytokine & Growth Factor Reviews (2002)
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.
Li Fan Lu;To Ha Thai;Dinis Pedro Calado;Ashutosh Chaudhry.
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Hideo Yasukawa;Hideo Yasukawa;Masanobu Ohishi;Hiroyuki Mori;Masaaki Murakami.
Nature Immunology (2003)
Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
Li Fan Lu;Mark P. Boldin;Ashutosh Chaudhry;Ling Li Lin.
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