Akihiko Yoshimura

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Japan Leader Award
• 2025 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Medicine in Japan Leader Award
• 2022 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• SOCS proteins, cytokine signalling and immune regulation.

  Akihiko Yoshimura;Tetsuji Naka;Masato Kubo

  1992
  Citations

• A new protein containing an SH2 domain that inhibits JAK kinases

  Takaho A. Endo;Masaaki Masuhara;Masahiro Yokouchi;Ritsu Suzuki

  1880
  Citations

• Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

  Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang

  1201
  Citations

• Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

  Li Fan Lu;Mark P. Boldin;Ashutosh Chaudhry;Ling Li Lin

  1074
  Citations

• Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.

  Seiji Okada;Masaya Nakamura;Hiroyuki Katoh;Tamaki Miyao

  1065
  Citations

• Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.

  Li Fan Lu;To Ha Thai;Dinis Pedro Calado;Ashutosh Chaudhry

  1036
  Citations

• Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.

  Takashi Shichita;Yuki Sugiyama;Hiroaki Ooboshi;Hiroaki Ooboshi;Hiroshi Sugimori

  984
  Citations

• Regulation of cytokine signaling and inflammation

  Toshitkatsu Hanada;Akihiko Yoshimura

  970
  Citations

• A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

  Akihiko Yoshimura;Tadashi Ohkubo;Toru Kiguchi;Nancy A. Jenkins

  963
  Citations

• IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

  Hideo Yasukawa;Masanobu Ohishi;Hiroyuki Mori;Masaaki Murakami

  960
  Citations

• The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

  Hideo Yasukawa;Hiroyuki Misawa;Hiroshi Sakamoto;Masaaki Masuhara

  945
  Citations

• Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

  Marina Lesina;Magdalena U. Kurkowski;Katharina Ludes;Stefan Rose-John

  902
  Citations

• SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

  Ichiko Kinjyo;Toshikatsu Hanada;Kyoko Inagaki-Ohara;Hiroyuki Mori

  846
  Citations

• Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.

  Zhi Chen;Arian Laurence;Yuka Kanno;Margit Pacher-Zavisin

  843
  Citations

• Suppressors of cytokine signaling and immunity

  Masato Kubo;Toshikatsu Hanada;Akihiko Yoshimura

  781
  Citations

• Negative Regulation of Cytokine Signaling Pathways

  Hideo Yasukawa;Atsuo Sasaki;Akihiko Yoshimura

  773
  Citations

• Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

  Hiroyuki Mori;Reiko Hanada;Toshikatsu Hanada;Daisuke Aki

  762
  Citations

• Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

  Atsunobu Takeda;Shinjiro Hamano;Atsushi Yamanaka;Toshikatsu Hanada

  713
  Citations

• Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3

  Takumi Kawaguchi;Takafumi Yoshida;Masaru Harada;Takao Hisamoto

  700
  Citations

• CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.

  Akira Matsumoto;Masaaki Masuhara;Masaaki Masuhara;Kaoru Mitsui;Kaoru Mitsui;Masahiro Yokouchi;Masahiro Yokouchi

  639
  Citations