D-Index & Metrics Best Publications
Akihiko Yoshimura

Akihiko Yoshimura

Biology and Biochemistry
Japan
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 120 Citations 62,644 469 World Ranking 262 National Ranking 10
Medicine D-index 116 Citations 47,558 341 World Ranking 1805 National Ranking 30

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cytokine
  • Immune system

The scientist’s investigation covers issues in Cell biology, Immunology, Molecular biology, SOCS3 and Cancer research. His research on Cell biology focuses in particular on Signal transduction. His work deals with themes such as SH2 domain, Receptor tyrosine kinase, Janus kinase 2, Phosphorylation and Leukemia inhibitory factor, which intersect with Molecular biology.

Leptin receptor is closely connected to Endocrinology in his research, which is encompassed under the umbrella topic of SOCS3. His Cancer research course of study focuses on Janus kinase and JAK-STAT signaling pathway and Kinase activity. The Cytokine study combines topics in areas such as Proinflammatory cytokine, Inflammation, Colitis and T cell.

His most cited work include:

  • A new protein containing an SH2 domain that inhibits JAK kinases (1309 citations)
  • SOCS proteins, cytokine signalling and immune regulation. (1125 citations)
  • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. (834 citations)

What are the main themes of his work throughout his whole career to date?

Akihiko Yoshimura mainly investigates Cell biology, Immunology, Cytokine, Molecular biology and Cancer research. Akihiko Yoshimura combines subjects such as Receptor and FOXP3 with his study of Cell biology. His study in Immunology focuses on Inflammation, Immune system, T cell, Interleukin 17 and Autoimmunity.

His research in Cytokine intersects with topics in Tumor necrosis factor alpha, Cellular differentiation, Suppressor of cytokine signaling 1, STAT1 and Proinflammatory cytokine. His Molecular biology research incorporates elements of SH2 domain and Pleckstrin homology domain. His SOCS3 research includes elements of Endocrinology and STAT protein.

He most often published in these fields:

  • Cell biology (42.11%)
  • Immunology (28.01%)
  • Cytokine (23.09%)

What were the highlights of his more recent work (between 2015-2021)?

  • Immunology (28.01%)
  • Cell biology (42.11%)
  • Immune system (11.38%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Immunology, Cell biology, Immune system, Inflammation and Cancer research. His Immunology research includes themes of Lung and Mycobacterium tuberculosis. His studies deal with areas such as Cellular differentiation, Cytokine, Transcription factor, Epigenetics and FOXP3 as well as Cell biology.

His research on Cytokine also deals with topics like

  • SOCS3 which is related to area like JAK-STAT signaling pathway and Glycoprotein 130,
  • Suppressor of cytokine signaling 1 which is related to area like Janus kinase. His research in Inflammation intersects with topics in Innate immune system and Neuroscience. Akihiko Yoshimura focuses mostly in the field of Cancer research, narrowing it down to topics relating to Cancer immunotherapy and, in certain cases, Stem cell and Transplantation.

Between 2015 and 2021, his most popular works were:

  • NR4A transcription factors limit CAR T cell function in solid tumours. (180 citations)
  • Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery (153 citations)
  • Induced Regulatory T Cells: Their Development, Stability, and Applications (137 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cytokine
  • Immune system

His scientific interests lie mostly in Immunology, Cell biology, FOXP3, Immune system and Genetics. His Immunology research is multidisciplinary, incorporating perspectives in Cancer research, Internal medicine and Drug. His study involves Janus kinase and SOCS3, a branch of Cell biology.

His study looks at the intersection of Janus kinase and topics like Innate immune system with Suppressor of cytokine signaling 1. Akihiko Yoshimura has included themes like Regulatory T cell, Interleukin 12, Antigen and DNA methylation in his FOXP3 study. The Immune system study combines topics in areas such as Liver disease, Primary sclerosing cholangitis and Ulcerative colitis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A new protein containing an SH2 domain that inhibits JAK kinases

Takaho A. Endo;Masaaki Masuhara;Masahiro Yokouchi;Ritsu Suzuki.
Nature (1997)

1779 Citations

SOCS proteins, cytokine signalling and immune regulation.

Akihiko Yoshimura;Tetsuji Naka;Masato Kubo.
Nature Reviews Immunology (2007)

1636 Citations

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang.
Nature Immunology (2006)

1089 Citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

Akihiko Yoshimura;Tadashi Ohkubo;Toru Kiguchi;Nancy A. Jenkins.
The EMBO Journal (1995)

888 Citations

The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

Hideo Yasukawa;Hiroyuki Misawa;Hiroshi Sakamoto;Masaaki Masuhara.
The EMBO Journal (1999)

888 Citations

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.

Seiji Okada;Masaya Nakamura;Hiroyuki Katoh;Tamaki Miyao.
Nature Medicine (2006)

877 Citations

Regulation of cytokine signaling and inflammation

Toshitkatsu Hanada;Akihiko Yoshimura.
Cytokine & Growth Factor Reviews (2002)

869 Citations

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.

Li Fan Lu;To Ha Thai;Dinis Pedro Calado;Ashutosh Chaudhry.
Immunity (2009)

848 Citations

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

Hideo Yasukawa;Hideo Yasukawa;Masanobu Ohishi;Hiroyuki Mori;Masaaki Murakami.
Nature Immunology (2003)

846 Citations

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

Li Fan Lu;Mark P. Boldin;Ashutosh Chaudhry;Ling Li Lin.
Cell (2010)

824 Citations

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