Atsuo T. Sasaki

Overview

Best Publications

• Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

  Arkaitz Carracedo;Li Ma;Li Ma;Li Ma;Julie Teruya-Feldstein;Federico Rojo

  1653
  Citations

• Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  1241
  Citations

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer

  1227
  Citations

• The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

  Hideo Yasukawa;Hiroyuki Misawa;Hiroshi Sakamoto;Masaaki Masuhara

  945
  Citations

• R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

  Rui Su;Lei Dong;Chenying Li;Sigrid Nachtergaele

  928
  Citations

• Negative Regulation of Cytokine Signaling Pathways

  Hideo Yasukawa;Atsuo Sasaki;Akihiko Yoshimura

  773
  Citations

• Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.

  Atsuo Sasaki;Hideo Yasukawa;Asuka Suzuki;Shintaro Kamizono

  523
  Citations

• Spred is a Sprouty-related suppressor of Ras signalling

  Toru Wakioka;Atsuo Sasaki;Reiko Kato;Reiko Kato;Takanori Shouda

  521
  Citations

• SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

  Jean Christophe Marine;Catriona McKay;Demin Wang;David J. Topham

  476
  Citations

• Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

  Atsuo T. Sasaki;Cheryl Chun;Kosuke Takeda;Richard A. Firtel

  451
  Citations

• CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2 *

  Atsuo Sasaki;Hideo Yasukawa;Takanori Shouda;Toshio Kitamura

  441
  Citations

• Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

  Isabel Garcia-Cao;Min Sup Song;Robin M. Hobbs;Robin M. Hobbs;Gaelle Laurent

  428
  Citations

• Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

  Atsuo Sasaki;Atsuo Sasaki;Takaharu Taketomi;Reiko Kato;Kazuko Saeki

  384
  Citations

• Cloning and Characterization of Novel CIS Family Genes

  Masaaki Masuhara;Hiroshi Sakamoto;Akira Matsumoto;Ritsu Suzuki

  317
  Citations

• SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130

  Ute Lehmann;Jochen Schmitz;Manuela Weissenbach;Radoslaw M. Sobota

  316
  Citations

• G protein–independent Ras/PI3K/F-actin circuit regulates basic cell motility

  Atsuo T. Sasaki;Chris Janetopoulos;Chris Janetopoulos;Susan Lee;Pascale G. Charest

  263
  Citations

• TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

  Susan Lee;Frank I. Comer;Atsuo Sasaki;Ian X. McLeod

  257
  Citations

• Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation

  Atsuo Sasaki;Takaharu Taketomi;Toru Wakioka;Reiko Kato

  228
  Citations

• A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

  Hiroshi Sakamoto;Hideo Yasukawa;Masaaki Masuhara;Shyu Tanimura

  219
  Citations

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Matthew G. Vander Heiden;Dimitrios Anastasiou;George Poulogiannis;John M. Asara

  3
  Citations