Fred Schaper mostly deals with Signal transduction, Cell biology, JAK-STAT signaling pathway, SOCS3 and Suppressor of cytokine signaling 1. His studies in Signal transduction integrate themes in fields like Immunology, Cytokine, Transcription factor, Transfection and Molecular biology. Fred Schaper works mostly in the field of Cell biology, limiting it down to concerns involving Proinflammatory cytokine and, occasionally, Acquired immune system.
His research integrates issues of Glycoprotein 130, Janus kinase and Suppressor of cytokine signalling in his study of JAK-STAT signaling pathway. His work deals with themes such as Janus kinase 1 and Protein tyrosine phosphatase, which intersect with Glycoprotein 130. His study deals with a combination of Suppressor of cytokine signalling and Tyrosine kinase 2.
His primary scientific interests are in Cell biology, Signal transduction, Glycoprotein 130, Molecular biology and Cytokine. His biological study deals with issues like Proinflammatory cytokine, which deal with fields such as Cell adhesion. His studies deal with areas such as Interleukin 6, Regulation of gene expression, Kinase and Immunology as well as Signal transduction.
His research in Glycoprotein 130 intersects with topics in JAK-STAT signaling pathway, Receptor, Protein tyrosine phosphatase, Receptor complex and Oncostatin M. He combines subjects such as Janus kinase, stat and STAT1 with his study of JAK-STAT signaling pathway. The concepts of his Molecular biology study are interwoven with issues in Cytoplasmic part, Transcription factor, Leukemia Inhibitory Factor Receptor alpha Subunit and Fusion protein.
His primary areas of investigation include Cell biology, MAPK/ERK pathway, Signal transduction, Cytokine and PI3K/AKT/mTOR pathway. His work in Kinase, Phosphorylation, SOCS3, Protein kinase A and STAT3 are all subfields of Cell biology research. His work on Suppressor of cytokine signalling as part of general SOCS3 study is frequently connected to Cavin, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His study in Signal transduction focuses on Glycoprotein 130 in particular. His research in Cytokine tackles topics such as Receptor which are related to areas like Interleukin 6 and Intracellular. His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in GAB1, STAT protein and Function.
His main research concerns Cell biology, Cytokine, Signal transduction, Janus kinase and STAT protein. His work on PI3K/AKT/mTOR pathway and Glycoprotein 130 as part of his general Cell biology study is frequently connected to Cavin, thereby bridging the divide between different branches of science. His PI3K/AKT/mTOR pathway research includes elements of STAT3 and Activator.
Fred Schaper interconnects Interleukin-6 receptor, Receptor expression and Receptor complex in the investigation of issues within Glycoprotein 130. Fred Schaper has researched Cytokine in several fields, including Cancer research and Protein kinase A. The Autocrine signalling study combines topics in areas such as Proinflammatory cytokine, Blockade and Intracellular.
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Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Peter C Heinrich;Iris Behrmann;Serge Haan;Heike M Hermanns.
Biochemical Journal (2003)
INTERLEUKIN-6-TYPE CYTOKINE SIGNALLING THROUGH THE GP130/JAK/STAT PATHWAY
Peter C. Heinrich;Iris Behrmann;Gerhard Müller-Newen;Fred Schaper.
Biochemical Journal (1998)
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Jochen Schmitz;Manuela Weissenbach;Serge Haan;Peter C. Heinrich.
Journal of Biological Chemistry (2000)
IFN-α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3
Johannes G Bode;Stephan Ludwig;Christina Ehrhardt;Ute Albrecht.
The FASEB Journal (2003)
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
Claudia Niemand;Ariane Nimmesgern;Serge Haan;Patrick Fischer.
Journal of Immunology (2003)
Interleukin-6: Biology, signaling and strategies of blockade.
Fred Schaper;Stefan Rose-John.
Cytokine & Growth Factor Reviews (2015)
Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.
Johannes G. Bode;Ute Albrecht;Dieter Häussinger;Peter C. Heinrich;Peter C. Heinrich.
European Journal of Cell Biology (2012)
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
Ute Lehmann;Jochen Schmitz;Manuela Weissenbach;Radoslaw M. Sobota.
Journal of Biological Chemistry (2003)
Plasticity and cross-talk of interleukin 6-type cytokines.
Christoph Garbers;Heike M. Hermanns;Fred Schaper;Gerhard Müller-Newen.
Cytokine & Growth Factor Reviews (2012)
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
Fred Schaper;Cornelia Gendo;Monika Eck;Jochen Schmitz.
Biochemical Journal (1998)
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