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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23858
World Ranking
4062
National Ranking
96

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Matthias Ernst is affiliated with La Trobe University in Australia and has a substantial body of research primarily in the fields of medicine and biochemistry, genetics, and molecular biology. Their work is concentrated in key subfields including molecular biology, oncology, immunology, pulmonary and respiratory medicine, and surgery.

The main topics explored in Ernst's research cover a range of areas related to cancer and immune system interactions. These include:

  • Cytokine Signaling Pathways and Interactions
  • Cancer Cells and Metastasis
  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • Cancer Mechanisms and Therapy
  • IL-33, ST2, and ILC Pathways

Their recent notable publications include the following papers:

  • "5S Study: Safe and Simple Single Shot Pulmonary Vein Isolation With Pulsed Field Ablation Using Sedation," published in 2022 in Circulation Arrhythmia and Electrophysiology
  • "Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies," 2023, Trends in Immunology
  • "Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Therapeutic Opportunities and Clinical Challenges," 2021, Cancers
  • "STAT3 Signaling in Breast Cancer: Multicellular Actions and Therapeutic Potential," 2022, Cancers
  • "Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis," 2022, European Respiratory Journal

Ernst has frequently published in a selection of key venues. These include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • STAR Protocols
  • Cancer Immunology Research

Collaborations are a consistent part of their research output. Frequent co-authors include:

  • Moritz F. Eissmann (25 joint publications)
  • Michael Büchert (21 joint publications)
  • Ashleigh R. Poh (19 joint publications)
  • John M. Mariadason (16 joint publications)
  • Shoukat Afshar-Sterle (15 joint publications)

Best Publications

  • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

    Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang

  • gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

    Julia Bollrath;Toby J Phesse;Vivian A von Burstin;Tracy Putoczki

  • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

    Jason S Stumhofer;Jonathan S Silver;Arian Laurence;Paige M Porrett

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

    Niall C. Tebbutt;Andrew S. Giraud;Melissa Inglese;Brendan Jenkins

  • Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones.

    Matthias Ernst;Joan K. Heath;Gideon A. Rodan

  • Targeting Macrophages in Cancer: From Bench to Bedside.

    Ashleigh R Poh;Matthias Ernst

  • IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

    Ceri Alan Fielding;Rachel Mary McLoughlin;Louise McLeod;Chantal Sophie Colmont

  • Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map.

    Jennifer Huynh;Ashwini Chand;Daniel Gough;Matthias Ernst

  • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

    Rachel Mary McLoughlin;Brendan J. Jenkins;Dianne Grail;Anwen Sian Williams

  • Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

    Tracy L. Putoczki;Tracy L. Putoczki;Stefan Thiem;Andrea Loving;Rita A. Busuttil;Rita A. Busuttil

  • STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

    Matthias Ernst;Meri Najdovska;Dianne Grail;Therese Lundgren-May

  • STAT3 Is Required for IL-6-gp130-Dependent Activation of Hepcidin In Vivo

    Antonello Pietrangelo;Uta Dierssen;Linda Valli;Cinzia Garuti

  • Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

    Brendan John Jenkins;Dianne Grail;Thao Nheu;Meri Najdovska

  • Acquiring signalling specificity from the cytokine receptor gp130

    Matthias Ernst;Brendan J Jenkins

  • IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

    Claire J Greenhill;Stefan Rose-John;Rami Lissilaa;Walter Ferlin

  • LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

    Helmut Butzkueven;Jian Guo Zhang;Merja Soilu-Hanninen;Hubertus Hochrein

  • Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.

    Matthias Ernst;Melissa Inglese;Paul Waring;Ian K. Campbell

  • Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3.

    Matthias Ernst;Gideon A. Rodan

  • CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

    Matthew James Watt;Nicolas Dzamko;Walter G Thomas;Stefan Rose-John

Frequent Co-Authors

Brendan J. Jenkins
Brendan J. Jenkins Hudson Institute of Medical Research
Joan K. Heath
Joan K. Heath Walter and Eliza Hall Institute of Medical Research
Robert G. Ramsay
Robert G. Ramsay Peter MacCallum Cancer Centre
Alex Boussioutas
Alex Boussioutas University of Melbourne
Stefan Rose-John
Stefan Rose-John Kiel University
Gary P. Anderson
Gary P. Anderson University of Melbourne
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth
Gordon K. Smyth Walter and Eliza Hall Institute of Medical Research
Ashley R. Dunn
Ashley R. Dunn Ludwig Cancer Research
Darryl A. Knight
Darryl A. Knight University of Newcastle Australia

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