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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
115
Citations
238256
World Ranking
771
National Ranking
19

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Gordon K. Smyth is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. Smyth's work is concentrated in several subfields, including Molecular Biology, Immunology, Cancer Research, Genetics, and Oncology.

The scientist's research topics cover a broad range within molecular biology and cancer studies. These include:

  • Genomics and Chromatin Dynamics
  • Gene expression and cancer classification
  • Epigenetics and DNA Methylation
  • Single-cell and spatial transcriptomics
  • T-cell and B-cell Immunology
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer

Their publication record includes contributions to major venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, European Urology Open Science, Cell Reports, and The EMBO Journal. These journals reflect a consistent focus on molecular and cellular biology, as well as cancer research.

Selected recent papers showcasing their work include:

  • A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast, 2021, The EMBO Journal
  • edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets, 2025, Nucleic Acids Research
  • Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling, 2020, Nature Cell Biology
  • Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition, 2021, Molecular Cell
  • edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators include Yunshun Chen, Alexandra L. Garnham, Jane E. Visvader, Hannah D. Coughlan, and Rhys S. Allan. These coauthors have contributed extensively alongside Smyth in various research projects and publications.

Best Publications

  • edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.

    Mark D. Robinson;Davis J. McCarthy;Gordon K. Smyth

  • limma powers differential expression analyses for RNA-sequencing and microarray studies

    Matthew E. Ritchie;Belinda Phipson;Di Wu;Yifang Hu

  • featureCounts: an efficient general-purpose program for assigning sequence reads to genomic features

    Yang Liao;Gordon K. Smyth;Wei Shi

  • Bioconductor: open software development for computational biology and bioinformatics

    Robert C Gentleman;Vincent J Carey;Douglas M. Bates;B.M. Bolstad

  • Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

    Gordon K Smyth

  • limma: Linear Models for Microarray Data

    G. K. Smyth

  • Gene ontology analysis for RNA-seq: accounting for selection bias

    Matthew D Young;Matthew J Wakefield;Gordon K Smyth;Alicia Oshlack

  • voom: precision weights unlock linear model analysis tools for RNA-seq read counts

    Charity W Law;Charity W Law;Yunshun Chen;Yunshun Chen;Wei Shi;Wei Shi;Gordon K Smyth;Gordon K Smyth

  • Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

    Davis J. McCarthy;Yunshun Chen;Gordon K. Smyth

  • Orchestrating high-throughput genomic analysis with Bioconductor

    Wolfgang Huber;Vincent J Carey;Robert Gentleman;Simon Anders

  • The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

    Yang Liao;Gordon K. Smyth;Wei Shi

  • Generation of a functional mammary gland from a single stem cell

    Mark Shackleton;Mark Shackleton;Francois Vaillant;Francois Vaillant;Kaylene J. Simpson;Kaylene J. Simpson;John Stingl

  • Normalization of cDNA microarray data.

    Gordon K Smyth;Terry Speed;Terry Speed

  • The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads.

    Yang Liao;Yang Liao;Gordon K Smyth;Gordon K Smyth;Wei Shi;Wei Shi

  • ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.

    Yifang Hu;Gordon K. Smyth

  • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

    Elgene Lim;Elgene Lim;Francois Vaillant;Di Wu;Di Wu;Natasha C Forrest

  • Use of within-array replicate spots for assessing differential expression in microarray experiments

    Gordon K. Smyth;Joëlle Michaud;Hamish S. Scott

  • Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

    Simon Anders;Davis J McCarthy;Davis J McCarthy;Yunshun Chen;Yunshun Chen;Michal Okoniewski

  • Small-sample estimation of negative binomial dispersion, with applications to SAGE data

    Mark D. Robinson;Gordon K. Smyth

  • Randomized Quantile Residuals

    Peter K. Dunn;Gordon K. Smyth

Frequent Co-Authors

Wei Shi
Wei Shi Monash University
Jane E. Visvader
Jane E. Visvader Walter and Eliza Hall Institute of Medical Research
Geoffrey J. Lindeman
Geoffrey J. Lindeman Peter MacCallum Cancer Centre
François Vaillant
François Vaillant Walter and Eliza Hall Institute of Medical Research
Matthew E. Ritchie
Matthew E. Ritchie Walter and Eliza Hall Institute of Medical Research
Stephen L. Nutt
Stephen L. Nutt Walter and Eliza Hall Institute of Medical Research
Gabrielle T. Belz
Gabrielle T. Belz University of Queensland
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Axel Kallies
Axel Kallies University of Melbourne
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research

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