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Biology and Biochemistry

D-Index
53
Citations
16276
World Ranking
15935
National Ranking
443

Overview

François Vaillant is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia, where their work focuses on molecular biology and oncology-related fields. Their research outputs contribute to a better understanding of cancer biology, particularly in breast cancer and tumor microenvironments.

The scientist's research spans multiple interconnected subfields, including:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Sociology and Political Science
  • Genetics

Vaillant's work covers a range of main topics such as:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • Cancer-related Molecular Pathways
  • Genomics and Chromatin Dynamics
  • Ubiquitin and proteasome pathways
  • Single-cell and spatial transcriptomics

The scientist has contributed to several notable publications over recent years. These include:

  • "A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast," 2021, The EMBO Journal
  • "Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling," 2020, Nature Cell Biology
  • "Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer," 2020, Clinical Cancer Research
  • "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," 2021, Nature Communications
  • "Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells," 2023, Cancer Discovery

Frequently collaborating with other researchers, François Vaillant has worked extensively with the following coauthors:

  • Jane E. Visvader
  • Geoffrey J. Lindeman
  • Gordon K. Smyth
  • Bianca D. Capaldo
  • Yunshun Chen

Most of Vaillant's publications appear in these outlets:

  • Alternatives Non-Violentes
  • The EMBO Journal
  • Nature Cell Biology
  • Cancer Research
  • Clinical Cancer Research

Best Publications

  • Generation of a functional mammary gland from a single stem cell

    Mark Shackleton;Mark Shackleton;Francois Vaillant;Francois Vaillant;Kaylene J. Simpson;Kaylene J. Simpson;John Stingl

  • Purification and unique properties of mammary epithelial stem cells

    John Stingl;Peter Eirew;Ian Ricketson;Mark Shackleton

  • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

    Elgene Lim;Elgene Lim;Francois Vaillant;Di Wu;Di Wu;Natasha C Forrest

  • Control of mammary stem cell function by steroid hormone signalling

    Marie Liesse Asselin-Labat;François Vaillant;Julie M. Sheridan;Bhupinder Pal

  • ROAST: rotation gene set tests for complex microarray experiments

    Di Wu;Elgene Lim;François Vaillant;Marie Liesse Asselin-Labat

  • Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

    Toula Bouras;Bhupinder Pal;François Vaillant;Gwyndolen Harburg

  • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

    Elgene Lim;Elgene Lim;Di Wu;Di Wu;Bhupinder Pal;Toula Bouras

  • The Mammary Progenitor Marker CD61/β3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

    François Vaillant;Marie Liesse Asselin-Labat;Mark Shackleton;Mark Shackleton;Natasha C. Forrest

  • Steroid Hormone Receptor Status of Mouse Mammary Stem Cells

    Marie Liesse Asselin-Labat;Mark Shackleton;Mark Shackleton;John Stingl;François Vaillant

  • Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer.

    Emma Nolan;Emma Nolan;Peter Savas;Peter Savas;Antonia N. Policheni;Antonia N. Policheni;Phillip K. Darcy;Phillip K. Darcy

  • Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

    François Vaillant;Delphine Merino;Delphine Merino;Lily Lee;Lily Lee;Kelsey Breslin

  • A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast.

    Bhupinder Pal;Yunshun Chen;Yunshun Chen;François Vaillant;François Vaillant;Bianca D Capaldo;Bianca D Capaldo

  • RANK ligand as a potential target for breast cancer prevention in BRCA1 -mutation carriers

    Emma Nolan;François Vaillant;François Vaillant;Daniel Branstetter;Bhupinder Pal;Bhupinder Pal

  • Patient-derived xenograft (PDX) models in basic and translational breast cancer research

    Lacey E. Dobrolecki;Susie D. Airhart;Denis G. Alferez;Samuel Aparicio

  • Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells.

    Jari A. Larm;François Vaillant;Anthony W. Linnane;Alfons Lawen

  • Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

    Samantha R. Oakes;François Vaillant;Elgene Lim;Lily Lee

  • Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays.

    B E Loveland;T G Johns;I R Mackay;F Vaillant

  • Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

    Delphine Merino;Delphine Merino;James R. Whittle;James R. Whittle;James R. Whittle;François Vaillant;François Vaillant;Antonin Serrano;Antonin Serrano

  • Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling.

    Bhupinder Pal;Bhupinder Pal;Yunshun Chen;Yunshun Chen;François Vaillant;François Vaillant;Paul Jamieson

  • Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2.

    Bhupinder Pal;Toula Bouras;Toula Bouras;Wei Shi;Wei Shi;François Vaillant;François Vaillant

Frequent Co-Authors

Jane E. Visvader
Jane E. Visvader Walter and Eliza Hall Institute of Medical Research
Geoffrey J. Lindeman
Geoffrey J. Lindeman Peter MacCallum Cancer Centre
Gordon K. Smyth
Gordon K. Smyth Walter and Eliza Hall Institute of Medical Research
Matthew E. Ritchie
Matthew E. Ritchie Walter and Eliza Hall Institute of Medical Research
Phillip Nagley
Phillip Nagley Monash University
Marco J. Herold
Marco J. Herold Walter and Eliza Hall Institute of Medical Research
James C. Neil
James C. Neil University of Glasgow
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Daniel H. D. Gray
Daniel H. D. Gray Walter and Eliza Hall Institute of Medical Research
Stephen B. Fox
Stephen B. Fox Peter MacCallum Cancer Centre

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