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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
105
Citations
46190
World Ranking
1184
National Ranking
31

Medicine

D-Index
105
Citations
46177
World Ranking
6714
National Ranking
191

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Ricky W. Johnstone is affiliated with the Peter MacCallum Cancer Centre in Australia. Their research spans fields primarily within Biochemistry, Genetics and Molecular Biology as well as Medicine. In these broad domains, they have contributed extensively to subfields including Molecular Biology, Immunology, Hematology, Oncology, and Epidemiology.

Their work covers several main topics, reflecting the depth and breadth of their research interests. These include Protein Degradation and Inhibitors, Histone Deacetylase Inhibitors Research, Immune Cell Function and Interaction, Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, RNA Modifications and Cancer, and CAR-T Cell Therapy Research.

Ricky W. Johnstone has a notable publication record with recent papers including:

  • Targeting the epigenetic regulation of antitumour immunity (2020, Nature Reviews Drug Discovery)
  • The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021, Cell)
  • Targeting transcription cycles in cancer (2021, Nature Reviews Cancer)
  • CDK13 cooperates with CDK12 to control global RNA polymerase II processivity (2020, Science Advances)
  • Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition (2021, Molecular Cell)

The scientist's frequent coauthors demonstrate collaborative efforts across multiple studies and include:

  • Stephin J. Vervoort
  • Simon J. Hogg
  • Izabela Todorovski
  • Lev M. Kats
  • Emily Gruber

Ricky W. Johnstone has published often in leading scientific venues. Their frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Science Advances
  • Experimental Hematology
  • Cell

The extensive research and publications demonstrate ongoing engagement in molecular and cancer biology, with particular focus on mechanisms controlling transcription, epigenetic regulation, and immune interactions relevant in cancer therapies.

Best Publications

  • Anticancer activities of histone deacetylase inhibitors.

    Jessica E. Bolden;Melissa J. Peart;Ricky W. Johnstone;Ricky W. Johnstone

  • Apoptosis: a link between cancer genetics and chemotherapy.

    Ricky W. Johnstone;Astrid A. Ruefli;Scott W. Lowe

  • Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

    Ricky W. Johnstone

  • Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

    Katrina J. Falkenberg;Ricky W. Johnstone

  • New and emerging HDAC inhibitors for cancer treatment.

    Alison C. West;Ricky W. Johnstone

  • The TRAIL apoptotic pathway in cancer onset, progression and therapy

    Ricky W. Johnstone;Ailsa J. Frew;Mark J. Smyth

  • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

    Mai Nguyen;Richard C. Marcellus;Anne Roulston;Mark Watson

  • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.

    Astrid A. Ruefli;Michael J. Ausserlechner;David Bernhard;Vivien R. Sutton

  • Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

    Melissa J. Peart;Gordon K. Smyth;Ryan K. van Laar;David D. Bowtell

  • Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?

    Ricky W Johnstone;Jonathan D Licht

  • Epigenetics in cancer: Targeting chromatin modifications

    Leigh Ellis;Peter W. Atadja;Ricky W. Johnstone

  • Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.

    Tengchuan Jin;Andrew Perry;Jiansheng Jiang;Patrick Smith

  • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

    Julian H. Elliott;Fiona Wightman;Ajantha Solomon;Khader Ghneim

  • Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.

    Megan J Bywater;Gretchen Poortinga;Gretchen Poortinga;Elaine Sanij;Elaine Sanij;Nadine Hein

  • BET inhibitor resistance emerges from leukaemia stem cells

    Chun Yew Fong;Omer Gilan;Omer Gilan;Enid Y N Lam;Alan Rubin

  • Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

    Daniel J. Gough;Nicole L. Messina;Nicole L. Messina;Christopher J.P. Clarke;Ricky W. Johnstone;Ricky W. Johnstone

  • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

    Vivien R. Sutton;Joanne E. Davis;Michael Cancilla;Ricky W. Johnstone

  • The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

    Mark J. Smyth;Erika Krasovskis;Vivien R. Sutton;Ricky W. Johnstone

  • P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death

    Ricky W. Johnstone;Erika Cretney;Mark J. Smyth

  • Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

    Adriana E. Tron;Matthew A. Belmonte;Ammar Adam;Brian M. Aquila;Brian M. Aquila

Frequent Co-Authors

Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Carleen Cullinane
Carleen Cullinane Peter MacCallum Cancer Centre
H. Miles Prince
H. Miles Prince Peter MacCallum Cancer Centre
Ross D. Hannan
Ross D. Hannan Australian National University
Phillip K. Darcy
Phillip K. Darcy Peter MacCallum Cancer Centre
Paul A. Beavis
Paul A. Beavis Peter MacCallum Cancer Centre
Paul G Ekert
Paul G Ekert University of New South Wales
Richard B. Pearson
Richard B. Pearson Peter MacCallum Cancer Centre

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