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Chemistry

D-Index
74
Citations
20776
World Ranking
4644
National Ranking
1465

Research.com Recognitions

  • 2002 - Fellow of the American Academy of Arts and Sciences
  • 2002 - Member of the National Academy of Sciences
  • 1983 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Richard Wolfenden is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, encompassing 34 publications.

The subfields of their work include:

  • Molecular Biology
  • Organic Chemistry
  • Physiology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Wolfenden's research covers a range of topics, notably:

  • Amino Acid Enzymes and Metabolism
  • Chemical Synthesis and Analysis
  • Protein Structure and Dynamics
  • Adenosine and Purinergic Signaling
  • Epigenetics and DNA Methylation
  • Photosynthetic Processes and Mechanisms
  • Biotin and Related Studies

Recent papers by Wolfenden include:

  • The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Non-enzymatic Methylation of Amino Acid Side Chains by SAM in Water, 2021, Biochemistry
  • Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1, 2020, OPAL (Open@LaTrobe) (La Trobe University)
  • Proton-in-Flight Mechanism for the Spontaneous Hydrolysis of N -Methyl O -Phenyl Sulfamate: Implications for the Design of Steroid Sulfatase Inhibitors, 2020, OPAL (Open@LaTrobe) (La Trobe University)
  • A persistent pesticide residue and the unusual catalytic proficiency of a dehalogenating enzyme, 2020, UNC Libraries
  • The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Nonenzymatic Methylation of Amino Acid Side-Chains by SAM in Water, 2021, bioRxiv (Cold Spring Harbor Laboratory)

The most frequent publication venues for Wolfenden are:

  • UNC Libraries
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Biochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include:

  • Charles A. Lewis
  • Randy B Stockbridge
  • Charles Lewis
  • Gottfried K. Schroeder
  • Yang Yuan

Wolfenden has been recognized with several awards, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 1983
  • Member of the National Academy of Sciences, 2002
  • Fellow of the American Academy of Arts and Sciences, 2002

Best Publications

  • A proficient enzyme

    Anna Radzicka;Richard Wolfenden

  • The depth of chemical time and the power of enzymes as catalysts.

    Richard Wolfenden;Mark J. Snider

  • Affinities of Amino Acid Side Chains for Solvent Water

    R. Wolfenden;L. Andersson;P. M. Cullis;C. C. B. Southgate

  • Analog approaches to the structure of the transition state in enzyme reactions

    Richard Wolfenden

  • Comparing the polarities of the amino acids: side-chain distribution coefficients between the vapor phase, cyclohexane, 1-octanol, and neutral aqueous solution

    Anna Radzicka;Richard Wolfenden

  • Transition State Analog Inhibitors and Enzyme Catalysis

    Richard Wolfenden

  • Rates of Uncatalyzed Peptide Bond Hydrolysis in Neutral Solution and the Transition State Affinities of Proteases

    Anna Radzicka;Richard Wolfenden

  • Transition State Analogues for Enzyme Catalysis

    Richard Wolfenden;Richard Wolfenden

  • Hydrogen bonding, hydrophobicity, packing, and protein folding

    George D. Rose;Richard Wolfenden

  • Cytidine Deaminase. The 2·3 Å Crystal Structure of an Enzyme: Transition-state Analog Complex

    Laurie Betts;Shibin Xiang;Steven A. Short;Richard Wolfenden

  • The ribosome as an entropy trap

    Annette Sievers;Malte Beringer;Marina V. Rodnina;Richard Wolfenden

  • Spontaneous Hydrolysis of Glycosides

    Richard Wolfenden;Xiangdong Lu;Gregory Young

  • The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases.

    Chetan Lad;Nicholas H. Williams;Richard Wolfenden

  • Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

    Brian G. Miller;Richard Wolfenden

  • The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

    Gottfried K. Schroeder;Chetan Lad;Paul Wyman;Nicholas H. Williams

  • Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

    Larry D. Byers;Richard Wolfenden

  • 1-Methyladenosine. Dimroth rearrangement and reversible reduction

    James B. Macon;Richard. Wolfenden

  • Interaction of the peptide bond with solvent water: a vapor phase analysis.

    Richard Wolfenden

  • Anatomy of a proficient enzyme: The structure of orotidine 5′-monophosphate decarboxylase in the presence and absence of a potential transition state analog

    Brian G. Miller;Anne M. Hassell;Richard Wolfenden;Michael V. Milburn

  • Water, Protein Folding, and the Genetic Code

    R. V. Wolfenden;P. M. Cullis;C. C. F. Southgate

Frequent Co-Authors

Charles W. Carter
Charles W. Carter University of North Carolina at Chapel Hill
Ronald Swanstrom
Ronald Swanstrom University of North Carolina at Chapel Hill
Paul D. Ellis
Paul D. Ellis Doty Scientific (United States)
Lee G. Pedersen
Lee G. Pedersen University of North Carolina at Chapel Hill
William P. Jencks
William P. Jencks Brandeis University
Iain D. Campbell
Iain D. Campbell University of Oxford
Richard A Williams
Richard A Williams Heriot-Watt University
Christoph H. Borchers
Christoph H. Borchers McGill University
Marina V. Rodnina
Marina V. Rodnina Max Planck Society
Victor E. Marquez
Victor E. Marquez National Institutes of Health

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