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Chemistry

D-Index
52
Citations
8309
World Ranking
13659
National Ranking
769

Overview

Jonathan P. Waltho is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Materials Science, with a strong emphasis on Molecular Biology, Materials Chemistry, Biochemistry, Neurology, and Clinical Biochemistry as subfields of study.

The scientist's work extensively covers several topics, including:

  • Enzyme Structure and Function
  • Biochemical and Molecular Research
  • Amino Acid Enzymes and Metabolism
  • Prion Diseases and Protein Misfolding
  • Neurological Diseases and Metabolism
  • Metabolism and Genetic Disorders
  • Protein Structure and Dynamics

Jonathan P. Waltho has contributed to a number of research articles published in various venues. Notable papers include:

  • "The Relationship between Enzyme Conformational Change, Proton Transfer, and Phosphoryl Transfer in β-Phosphoglucomutase," 2021, ACS Catalysis
  • "Allomorphy as a mechanism of post-translational control of enzyme activity," 2020, Nature Communications
  • "Structural effects of the highly protective V127 polymorphism on human prion protein," 2020, Communications Biology
  • "Deconvolution of conformational exchange from Raman spectra of aqueous RNA nucleosides," 2020, Communications Chemistry
  • "An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition," 2022, ACS Catalysis

The researcher has frequently published in several journals, with multiple contributions to ACS Catalysis, Communications Biology, Structure, bioRxiv (Cold Spring Harbor Laboratory), and SSRN Electronic Journal.

They have collaborated regularly with a group of co-authors, including:

  • Matthew J. Cliff
  • Nicola J. Baxter
  • Andrea M. Hounslow
  • Yi Jin
  • Hugh R. W. Dannatt

Best Publications

  • Location and properties of metal-binding sites on the human prion protein.

    Graham S. Jackson;Ian Murray;Laszlo L. P. Hosszu;Nicholas Gibbs

  • Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrilogenic Conformations

    G. S. Jackson;L. L. P. Hosszu;L. L. P. Hosszu;A. Power;A. F. Hill

  • Calcium-induced structural changes and domain autonomy in calmodulin.

    Bryan E. Finn;Johan Evenäs;Torbjörn Drakenberg;Jonathan P. Waltho

  • Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones

    P Thaw;N.J Baxter;A.M Hounslow;C Price

  • Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily.

    Rosemary A. Staniforth;Silva Giannini;Lee D. Higgins;Matthew J. Conroy

  • Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin.

    Waltho Jp;Feher Va;Merutka G;Dyson Hj

  • Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.

    L G Czaplewski;J McKeating;C J Craven;L D Higgins

  • Why did Nature select phosphate for its dominant roles in biology

    Matthew W. Bowler;Matthew J. Cliff;Jonathan P. Waltho;G. Michael Blackburn

  • Simultaneously Enhancing Spectral Resolution and Sensitivity in Heteronuclear Correlation NMR Spectroscopy

    Liladhar Paudel;Ralph W Adams;Peter Kiraly;Peter Kiraly;Juan A Aguilar;Juan A Aguilar

  • Structural mobility of the human prion protein probed by backbone hydrogen exchange.

    L L Hosszu;N J Baxter;G S Jackson;A Power

  • Multiple folding pathways for heterologously expressed human prion protein

    Graham S. Jackson;Andrew F. Hill;Catherine Joseph;Laszlo Hosszu

  • Aspects of molecular recognition: solvent exclusion and dimerization of the antibiotic ristocetin when bound to a model bacterial cell-wall precursor

    Jonathan P. Waltho;Dudley H. Williams

  • Function of the amino sugar and N-terminal amino acid of the antibiotic vancomycin in its complexation with cell wall peptides

    Rajamoorthi. Kannan;Constance M. Harris;Thomas M. Harris;Jonathan P. Waltho

  • The three-dimensional solution structure of human stefin A.

    J.R. Martin;C.J. Craven;R. Jerala;L. Kroon-Zitko

  • Molecular basis of the activity of antibiotics of the vancomycin group

    D. H. Williams;J. P. Waltho

  • Cystatin forms a Tetramer through Structural Rearrangement of Domain-swapped Dimers prior to Amyloidogenesis

    Anna Sanders;C. Jeremy Craven;Lee D. Higgins;Silva Giannini

  • Peptide models of protein folding initiation sites. 3. The G-H helical hairpin of myoglobin.

    Shin Hc;Merutka G;Waltho Jp;Tennant Ll

  • Essential role of proline isomerization in stefin B tetramer formation.

    Saša Jenko Kokalj;Gregor Gunčar;Igor Štern;Gareth Morgan

  • Obligate Heterodimerization of the Archaeal Alba2 Protein with Alba1 Provides a Mechanism for Control of DNA Packaging

    Clare Jelinska;Matthew J. Conroy;C. Jeremy Craven;Andrea M. Hounslow

  • Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions

    Christopher Pudney;Andrew Guerriero;Nicola Jane Baxter;Nicola Jane Baxter;Linus O Johannissen

Frequent Co-Authors

G. Michael Blackburn
G. Michael Blackburn University of Sheffield
Dudley H. Williams
Dudley H. Williams University of Cambridge
John Collinge
John Collinge University College London
Anthony R. Clarke
Anthony R. Clarke University of Bristol
Christopher A. Hunter
Christopher A. Hunter University of Pennsylvania
Vito Turk
Vito Turk Jožef Stefan Institute
Nicholas H. Williams
Nicholas H. Williams University of Sheffield
Roman Jerala
Roman Jerala National Institute of Chemistry
Nigel S. Scrutton
Nigel S. Scrutton University of Manchester
Peter E. Wright
Peter E. Wright Scripps Research Institute

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