World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
15252
World Ranking
11243
National Ranking
320

Overview

Giuseppe Legname is affiliated with the International School for Advanced Studies in Italy. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Among subfields, Legname's work focuses notably on Molecular Biology, Neurology, Nutrition and Dietetics, Physiology, and Cellular and Molecular Neuroscience.

The main research topics covered by Legname include:

  • Prion Diseases and Protein Misfolding
  • Neurological Diseases and Metabolism
  • Trace Elements in Health
  • Alzheimer's Disease Research and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Olfactory and Sensory Function Studies

Their publication record comprises numerous papers published in specialized journals and prominent venues. Frequent publication venues include:

  • Progress in Molecular Biology and Translational Science
  • PLoS Pathogens
  • Molecular Neurobiology
  • Molecular Neurodegeneration
  • Alzheimer's & Dementia

Selected recent papers authored or co-authored by Giuseppe Legname include:

  • TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients (2020, Brain Communications)
  • Serpin Signatures in Prion and Alzheimer's Diseases (2022, Molecular Neurobiology)
  • Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories (2021, Molecular Neurodegeneration)
  • The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells (2020, Journal of Neurochemistry)
  • Expression pattern of perilipins in human brain during aging and in Alzheimer's disease (2021, Neuropathology and Applied Neurobiology)

Legname collaborates regularly with a core group of researchers. Frequent co-authors include:

  • Fabio Moda
  • Luigi Celauro
  • Edoardo Bistaffa
  • Marco Zattoni
  • Federico Angelo Cazzaniga

Best Publications

  • Synthetic Mammalian Prions

    Giuseppe Legname;Ilia V. Baskakov;Hoang-Oanh B. Nguyen;Detlev Riesner

  • Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

    David Peretz;R. Anthony Williamson;Kiotoshi Kaneko;Julie Vergara

  • Pathway complexity of prion protein assembly into amyloid.

    Ilia V. Baskakov;Giuseppe Legname;Michael A. Baldwin;Stanley B. Prusiner

  • Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.

    Gerold Schmitt-Ulms;Giuseppe Legname;Michael A Baldwin;Haydn L Ball

  • Copper coordination in the full-length, recombinant prion protein.

    Colin S. Burns;Eliah Aronoff-Spencer;Giuseppe Legname;Stanley B. Prusiner

  • Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

    Ilaria Prada;Martina Gabrielli;Elena Turola;Alessia Iorio

  • Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles.

    P Joshi;E Turola;A Ruiz;A Bergami

  • Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.

    Jiri G. Safar;Michael Scott;Jeff Monaghan;Camille Deering

  • Folding of Prion Protein to Its Native α-Helical Conformation Is under Kinetic Control

    Ilia V. Baskakov;Giuseppe Legname;Stanley B. Prusiner;Fred E. Cohen

  • A Change in the Conformation of Prions Accompanies the Emergence of a New Prion Strain

    David Peretz;R.Anthony Williamson;Giuseppe Legname;Yoichi Matsunaga

  • Prion detection by an amyloid seeding assay.

    David W. Colby;Qiang Zhang;Shuyi Wang;Darlene Groth

  • Design and construction of diverse mammalian prion strains.

    David W. Colby;Kurt Giles;Giuseppe Legname;Holger Wille

  • The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation.

    Rose Zamoyska;Albert Basson;Andrew Filby;Giuseppe Legname

  • Cytosolic Prion Protein in Neurons

    Alexander Mironov;Diane Latawiec;Holger Wille;Essia Bouzamondo-Bernstein

  • Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

    Giuseppe Legname;Hoang-Oanh B. Nguyen;David Peretz;Fred E. Cohen

  • Strain-specified characteristics of mouse synthetic prions

    Giuseppe Legname;Hoang-Oanh B. Nguyen;Ilia V. Baskakov;Fred E. Cohen

  • Prions in skeletal muscle

    Patrick J. Bosque;Chongsuk Ryou;Glenn Telling;David Peretz

  • Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

    Jamil Kanaani;Stanley B. Prusiner;Julia Diacovo;Steinunn Baekkeskov

  • Protease-Sensitive Synthetic Prions

    David W. Colby;Rachel Wain;Ilia V. Baskakov;Giuseppe Legname

  • Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein

    Jesús R. Requena;Darlene Groth;Giuseppe Legname;Earl R. Stadtman

Frequent Co-Authors

Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Paolo Carloni
Paolo Carloni Forschungszentrum Jülich
Maria Laura Bolognesi
Maria Laura Bolognesi University of Bologna
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Fabrizio Tagliavini
Fabrizio Tagliavini Istituto Neurologico Carlo Besta
Ilia V. Baskakov
Ilia V. Baskakov University of Maryland, Baltimore
Andrea Cavalli
Andrea Cavalli Italian Institute of Technology
Frederick Cohen
Frederick Cohen Nurix Therapeutics
Claudia Verderio
Claudia Verderio University of Milan
Stefano Gustincich
Stefano Gustincich Italian Institute of Technology

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