2026 Byron Caughey: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	100	1521	1367	856	753	280	35069

Overview

Byron Caughey is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research primarily focuses on neurodegenerative diseases, with significant work in prion diseases and protein misfolding.

Their frequent publication venues include:

bioRxiv (Cold Spring Harbor Laboratory)
Acta Neuropathologica
Acta Neuropathologica Communications
PLoS Pathogens
Annals of Clinical and Translational Neurology

Caughey's main fields of study cover Medicine and Biochemistry, Genetics, and Molecular Biology, with notable subfields being Neurology, Molecular Biology, Physiology, Nutrition and Dietetics, and Psychiatry and Mental health.

The main research topics include:

Prion Diseases and Protein Misfolding
Parkinson's Disease Mechanisms and Treatments
Alzheimer's disease research and treatments
Neurological diseases and metabolism
Neurological disorders and treatments
Trace Elements in Health
Ginkgo biloba and Cashew Applications

Some recent papers authored or co-authored by Caughey are:

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies, 2020, Acta Neuropathologica
Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease, 2021, The Lancet Neurology
Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease, 2020, JAMA Neurology
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease, 2021, Acta Neuropathologica Communications
High-resolution structure and strain comparison of infectious mammalian prions, 2021, Molecular Cell

Caughey collaborates frequently with several researchers including:

Christina D. Orrú
Andrew G. Hughson
Bradley R. Groveman
Efrosini Artikis
Allison Kraus

Best Publications

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

Byron Caughey;Peter T. Lansbury

2145
Citations
Cell-free formation of protease-resistant prion protein

David A. Kocisko;David A. Kocisko;Jon H. Come;Jon H. Come;Suzette A. Priola;Bruce Chesebro

1215
Citations
The most infectious prion protein particles

Jay R. Silveira;Gregory J. Raymond;Andrew G. Hughson;Richard E. Race

1097
Citations
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

Byron W. Caughey;Aichun Dong;Kolari S. Bhat;Darwin Ernst

1050
Citations
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

B. Caughey;G.J. Raymond

852
Citations
Anchorless prion protein results in infectious amyloid disease without clinical scrapie.

Bruce Chesebro;Bruce Chesebro;Bruce Chesebro;Matthew Trifilo;Matthew Trifilo;Matthew Trifilo;Richard Race;Richard Race;Richard Race;Kimberly Meade-White;Kimberly Meade-White;Kimberly Meade-White

773
Citations
Non-genetic propagation of strain-specific properties of scrapie prion protein.

Richard A. Bessen;David A. Kocisko;David A. Kocisko;Gregory J. Raymond;Santosh Nandan

675
Citations
Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays

Jason M. Wilham;Christina D. Orrú;Christina D. Orrú;Richard A. Bessen;Ryuichiro Atarashi

576
Citations
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state.

B Caughey;G J Raymond;D Ernst;R E Race

514
Citations
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.

B Caughey;G J Raymond

511
Citations
Species specificity in the cell-free conversion of prion protein to protease-resistant forms : A model for the scrapie species barrier

David A. Kocisko;Suzette A. Priola;Gregory J. Raymond;Bruce Chesebro

474
Citations
Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells.

B Caughey;R E Race;D Ernst;M J Buchmeier

437
Citations
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.

Ryuichiro Atarashi;Roger A Moore;Valerie L Sim;Andrew G Hughson

411
Citations
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt–Jakob disease

Lynne I. McGuire;Alexander H. Peden;Christina D. Orrú;Jason M. Wilham

411
Citations
Lysosomotropic Agents and Cysteine Protease Inhibitors Inhibit Scrapie-Associated Prion Protein Accumulation

Katsumi Doh-ura;Toru Iwaki;Byron Caughey

408
Citations
Strain-dependent differences in beta-sheet conformations of abnormal prion protein.

Byron Caughey;Gregory J. Raymond;Richard A. Bessen

390
Citations
Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions*

Byron Caughey;Gerald S Baron;Bruce Chesebro;Martin Jeffrey

382
Citations
A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

Christina D. Orrú;Matilde Bongianni;Giovanni Tonoli;Sergio Ferrari

378
Citations
New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

David A. Kocisko;Gerald S. Baron;Richard Rubenstein;Jiancao Chen

367
Citations
Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease.

G.J. Raymond;A. Bossers;L.D. Raymond;K.I. O'Rourke

361
Citations