D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 81 Citations 25,602 187 World Ranking 1649 National Ranking 948

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Scrapie, Biochemistry, Virology, Prion protein and PrPSc Proteins are his primary areas of study. His Scrapie study incorporates themes from In vitro, Recombinant DNA, Molecular biology, Hamster and Amyloid. His work in the fields of Protease, Gene isoform, Sulfation and Protein folding overlaps with other areas such as Congo red.

Bioassay is closely connected to Transmissible mink encephalopathy in his research, which is encompassed under the umbrella topic of Virology. His Prion protein study combines topics in areas such as Cerebrospinal fluid and Immunology. His PrPSc Proteins study deals with Transmissible spongiform encephalopathy intersecting with Cell-free system.

His most cited work include:

  • Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. (1419 citations)
  • Cell-free formation of protease-resistant prion protein (774 citations)
  • The most infectious prion protein particles (758 citations)

What are the main themes of his work throughout his whole career to date?

Byron Caughey mainly focuses on Scrapie, Virology, Biochemistry, Prion protein and In vitro. Byron Caughey interconnects Molecular biology, Cell culture, Recombinant DNA and In vivo in the investigation of issues within Scrapie. His Virology study which covers Transmissible spongiform encephalopathy that intersects with Chronic wasting disease.

Biochemistry is closely attributed to Amyloid in his research. His Amyloid research integrates issues from Fibril, Protein aggregation and Glycosaminoglycan. The study incorporates disciplines such as Immunology, Pathogenesis and Cell biology in addition to Prion protein.

He most often published in these fields:

  • Scrapie (39.34%)
  • Virology (34.84%)
  • Biochemistry (29.92%)

What were the highlights of his more recent work (between 2017-2021)?

  • Pathology (13.93%)
  • Disease (13.11%)
  • In vitro (17.62%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Pathology, Disease, In vitro, Cerebrospinal fluid and Synucleinopathies. His research investigates the link between Disease and topics such as Neuroscience that cross with problems in Animal model. His research integrates issues of Infectivity, Scrapie and Olfactory mucosa in his study of In vitro.

His Scrapie research is multidisciplinary, relying on both Cell, Cell culture and Encephalopathy. Byron Caughey works mostly in the field of Biochemistry, limiting it down to topics relating to Progressive supranuclear palsy and, in certain cases, Thioflavin. In his work, Genetically modified mouse is strongly intertwined with Virology, which is a subfield of Asymptomatic.

Between 2017 and 2021, his most popular works were:

  • Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC (98 citations)
  • Antisense oligonucleotides extend survival of prion-infected mice (42 citations)
  • Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. (41 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Internal medicine

Byron Caughey focuses on Pathology, Disease, Cerebrospinal fluid, Synucleinopathies and Dementia with Lewy bodies. The Neurodegeneration research Byron Caughey does as part of his general Disease study is frequently linked to other disciplines of science, such as Tolerability, therefore creating a link between diverse domains of science. His work in Cerebrospinal fluid addresses subjects such as Biomarker, which are connected to disciplines such as Protein Misfolding Cyclic Amplification, Transgene, Virology, Genetically modified mouse and Mesocricetus.

The concepts of his Synucleinopathies study are interwoven with issues in Lewy body and Biochemistry, Solubilization, Protein folding. The Dementia with Lewy bodies study combines topics in areas such as In vitro and Synuclein. Byron Caughey has included themes like Fibril, Alzheimer's disease and Recombinant DNA in his Molecular biology study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

Byron Caughey;Peter T. Lansbury.
Annual Review of Neuroscience (2003)

1943 Citations

Cell-free formation of protease-resistant prion protein

David A. Kocisko;David A. Kocisko;Jon H. Come;Jon H. Come;Suzette A. Priola;Bruce Chesebro.
Nature (1994)

1139 Citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

Byron W. Caughey;Aichun Dong;Kolari S. Bhat;Darwin Ernst.
Biochemistry (1991)

1011 Citations

The most infectious prion protein particles

Jay R. Silveira;Gregory J. Raymond;Andrew G. Hughson;Richard E. Race.
Nature (2005)

995 Citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

B. Caughey;G.J. Raymond.
Journal of Biological Chemistry (1991)

815 Citations

Anchorless prion protein results in infectious amyloid disease without clinical scrapie.

Bruce Chesebro;Matthew Trifilo;Richard Race;Kimberly Meade-White.
Science (2005)

700 Citations

Non-genetic propagation of strain-specific properties of scrapie prion protein.

Richard A. Bessen;David A. Kocisko;David A. Kocisko;Gregory J. Raymond;Santosh Nandan.
Nature (1995)

632 Citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state.

B Caughey;G J Raymond;D Ernst;R E Race.
Journal of Virology (1991)

492 Citations

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.

B Caughey;G J Raymond.
Journal of Virology (1993)

481 Citations

Species specificity in the cell-free conversion of prion protein to protease-resistant forms : A model for the scrapie species barrier

David A. Kocisko;Suzette A. Priola;Gregory J. Raymond;Bruce Chesebro.
Proceedings of the National Academy of Sciences of the United States of America (1995)

448 Citations

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