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Microbiology

D-Index
84
Citations
24404
World Ranking
934
National Ranking
431

Overview

Bruce Chesebro is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, molecular biology, and neuroscience, with significant contributions in molecular biology, neurology, biochemistry, immunology, and physiology. The scientist's work centers on topics such as prion diseases and protein misfolding, neuroinflammation and neurodegeneration mechanisms, amino acid enzymes and metabolism, Alzheimer's disease research and treatments, neurological diseases and metabolism, as well as RNA regulation and disease.

Several recent publications illustrate the scope of Chesebro's research:

  • RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection, 2020, Molecular Brain
  • Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses, 2021, Acta Neuropathologica Communications
  • Second passage experiments of chronic wasting disease in transgenic mice overexpressing human prion protein, 2022, Veterinary Research
  • Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia, 2021, Journal of Neuroinflammation
  • Efficacy of Wex-cide 128 disinfectant against multiple prion strains, 2023, PLoS ONE

Chesebro collaborates frequently with several other researchers, reflecting a broad network within their specialized fields. Frequent co-authors include Brent Race, James F. Striebel, James A. Carroll, Katie Williams, and Chase Baune.

Their research has been published in a range of scientific journals, most notably:

  • PLoS ONE
  • Molecular Brain
  • Veterinary Research
  • Acta Neuropathologica Communications
  • Journal of Neuroinflammation

The scientist's contribution to understanding prion diseases, neurodegenerative mechanisms, and molecular biology is signified through their extensive work in both experimental studies and immune response investigations. This includes examination of gene expression in glial cells during prion infection, investigation of prion-induced retinal degeneration, and studies on the efficacy of disinfectants against prion strains.

Best Publications

  • Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1

    Emily J. Platt;Kathy Wehrly;Shawn E. Kuhmann;Bruce Chesebro

  • Cell-free formation of protease-resistant prion protein

    David A. Kocisko;David A. Kocisko;Jon H. Come;Jon H. Come;Suzette A. Priola;Bruce Chesebro

  • Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism.

    B Chesebro;K Wehrly;J Nishio;S Perryman

  • Anchorless prion protein results in infectious amyloid disease without clinical scrapie.

    Bruce Chesebro;Bruce Chesebro;Bruce Chesebro;Matthew Trifilo;Matthew Trifilo;Matthew Trifilo;Richard Race;Richard Race;Richard Race;Kimberly Meade-White;Kimberly Meade-White;Kimberly Meade-White

  • Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.

    Bruce Chesebro;Richard Race;Kathy Wehrly;Jane Nishio

  • Species specificity in the cell-free conversion of prion protein to protease-resistant forms : A model for the scrapie species barrier

    David A. Kocisko;Suzette A. Priola;Gregory J. Raymond;Bruce Chesebro

  • Affinity labeling of a phosphorylcholine binding mouse myeloma protein.

    Bruce Chesebro;Henry Metzger

  • Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity.

    B Chesebro;K Wehrly

  • Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells.

    B Caughey;R E Race;D Ernst;M J Buchmeier

  • Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions*

    Byron Caughey;Gerald S Baron;Bruce Chesebro;Martin Jeffrey

  • Sulfated glycans and elevated temperature stimulate PrPSc-dependent cell-free formation of protease-resistant prion protein

    Cai'ne Wong;Liang-Wen Xiong;Motohiro Horiuchi;Lynne Raymond

  • Multidrug-Resistant Human Immunodeficiency Virus Type 1 Strains Resulting from Combination Antiretroviral Therapy

    Astrid K N Iversen;Robert W. Shafer;Kathy Wehrly;Mark A. Winters

  • Conversion of raft associated prion protein to the protease‐resistant state requires insertion of PrP‐res (PrPSc) into contiguous membranes

    Gerald S. Baron;Kathy Wehrly;David W. Dorward;Bruce Chesebro

  • Characterization of scrapie infection in mouse neuroblastoma cells.

    Richard E. Race;Laverne H. Fadness;Bruce Chesebro

  • Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells.

    B Chesebro;R Buller;J Portis;K Wehrly

  • Characterization of mouse monoclonal antibodies specific for Friend murine leukemia virus-induced erythroleukemia cells: friend-specific and FMR-specific antigens.

    B. Chesebro;K. Wehrly;M. Cloyd;W. Britt

  • Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

    Alex J. Raeber;Richard E. Race;Sebastian Brandner;Suzette A. Priola

  • Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

    Camille Locht;Bruce Chesebro;Richard Race;Jerry M. Keith

  • Specific Inhibition of in Vitro Formation of Protease-resistant Prion Protein by Synthetic Peptides

    Joe¨lle Chabry;Byron Caughey;Bruce Chesebro

  • Prion protein and the transmissible spongiform encephalopathies.

    Byron Caughey;Bruce Chesebro

Frequent Co-Authors

Richard E. Race
Richard E. Race National Institutes of Health
Byron Caughey
Byron Caughey National Institute of Allergy and Infectious Diseases
Kim J. Hasenkrug
Kim J. Hasenkrug National Institutes of Health
Michael B. A. Oldstone
Michael B. A. Oldstone Scripps Research Institute
Christopher Power
Christopher Power University of Alberta
Richard T. Johnson
Richard T. Johnson Johns Hopkins University School of Medicine
David W. Dorward
David W. Dorward National Institutes of Health
Michael W. Miller
Michael W. Miller MSD (United States)
David Kabat
David Kabat Oregon Health & Science University
Martin Jeffrey
Martin Jeffrey Animal and Plant Health Agency

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