D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 85 Citations 27,037 248 World Ranking 2010 National Ranking 1125

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Biochemistry

His primary areas of investigation include Virology, Protein folding, Amyloid, Biochemistry and Disease. His Virology study integrates concerns from other disciplines, such as Scrapie, Protein Misfolding Cyclic Amplification, Prion protein, In vitro and Infectious agent. The concepts of his Scrapie study are interwoven with issues in Unfolded protein response and Endoplasmic reticulum.

His Protein folding research is multidisciplinary, incorporating perspectives in Fungal prion, PrPSc Proteins, Protein aggregation and Molecular mechanism. His Amyloid research is multidisciplinary, incorporating elements of Biochemistry of Alzheimer's disease, P3 peptide and Cell biology. His research investigates the connection between Disease and topics such as Immunology that intersect with issues in Blood–brain barrier and Internal medicine.

His most cited work include:

  • Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding (996 citations)
  • Unfolding the role of protein misfolding in neurodegenerative diseases. (985 citations)
  • Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. (735 citations)

What are the main themes of his work throughout his whole career to date?

Claudio Soto mostly deals with Virology, Disease, Protein folding, Biochemistry and Cell biology. His Virology research incorporates elements of Scrapie, Protein Misfolding Cyclic Amplification, Prion protein and Bovine spongiform encephalopathy. His research integrates issues of Transmission, In vitro and Cerebrospinal fluid in his study of Protein Misfolding Cyclic Amplification.

His work deals with themes such as Neuroscience, Immunology and In vivo, which intersect with Disease. His Protein folding research incorporates elements of PrPSc Proteins, Computational biology, Protein aggregation and Molecular mechanism. Claudio Soto combines subjects such as Transgene and Pathogenesis with his study of Cell biology.

He most often published in these fields:

  • Virology (28.00%)
  • Disease (28.00%)
  • Protein folding (25.45%)

What were the highlights of his more recent work (between 2017-2021)?

  • Disease (28.00%)
  • Neuroscience (16.36%)
  • Pathology (12.36%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Disease, Neuroscience, Pathology, Protein Misfolding Cyclic Amplification and Parkinson's disease. His work carried out in the field of Disease brings together such families of science as In vivo and Virology. His Infectivity study in the realm of Virology connects with subjects such as Hiv infected.

In general Neuroscience study, his work on Dopamine often relates to the realm of Traumatic brain injury, thereby connecting several areas of interest. His Protein Misfolding Cyclic Amplification study combines topics from a wide range of disciplines, such as Transmission, Bovine spongiform encephalopathy, Cerebrospinal fluid and Neurodegeneration. His research on Biochemistry focuses in particular on Protein folding.

Between 2017 and 2021, his most popular works were:

  • Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. (240 citations)
  • Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy. (103 citations)
  • Modeling amyloid beta and tau pathology in human cerebral organoids (82 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His main research concerns Protein Misfolding Cyclic Amplification, Disease, Neuroscience, Infectivity and Neurodegeneration. His Protein Misfolding Cyclic Amplification research is multidisciplinary, incorporating elements of Cerebrospinal fluid, Oncology, Parkinson's disease, Transmission and Cell biology. His research integrates issues of Virus, Virology, Mesocricetus and Single-nucleotide polymorphism in his study of Disease.

His study in Infectivity is interdisciplinary in nature, drawing from both Toxicity, Protein engineering, Brain damage, In vivo and Gene isoform. His biological study spans a wide range of topics, including Scrapie, Bovine spongiform encephalopathy, Chaperone and Infectious agent. His Scrapie study deals with Protein aggregation intersecting with Protein structure and Protein folding.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

Gabriela P. Saborio;Bruno Permanne;Claudio Soto.
Nature (2001)

1553 Citations

Unfolding the role of protein misfolding in neurodegenerative diseases.

Claudio Soto.
Nature Reviews Neuroscience (2003)

1533 Citations

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

Claudio Soto;Einar M. Sigurdsson;Laura Morelli;R. Asok Kumar.
Nature Medicine (1998)

1026 Citations

In Vitro Generation of Infectious Scrapie Prions

Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto.
Cell (2005)

957 Citations

Converting a peptide into a drug: strategies to improve stability and bioavailability.

Celine Adessi;Claudio Soto.
Current Medicinal Chemistry (2002)

728 Citations

Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation

Claudio Soto;Mark S. Kindy;Marc Baumann;Blas Frangione.
Biochemical and Biophysical Research Communications (1996)

574 Citations

Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.

C. Lasagna-Reeves;D. Gonzalez-Romero;D. Gonzalez-Romero;M. A. Barria;M. A. Barria;I. Olmedo;I. Olmedo.
Biochemical and Biophysical Research Communications (2010)

564 Citations

An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

Shi Du Yan;Jin Fu;Claudio Soto;Xi Chen.
Nature (1997)

501 Citations

Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

Claudio Hetz;Milene Russelakis‐Carneiro;Kinsey Maundrell;Joaquin Castilla.
The EMBO Journal (2003)

477 Citations

Protein misfolding and disease; protein refolding and therapy.

Claudio Soto.
FEBS Letters (2001)

426 Citations

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