His primary areas of investigation include Virology, Protein folding, Amyloid, Biochemistry and Disease. His Virology study integrates concerns from other disciplines, such as Scrapie, Protein Misfolding Cyclic Amplification, Prion protein, In vitro and Infectious agent. The concepts of his Scrapie study are interwoven with issues in Unfolded protein response and Endoplasmic reticulum.
His Protein folding research is multidisciplinary, incorporating perspectives in Fungal prion, PrPSc Proteins, Protein aggregation and Molecular mechanism. His Amyloid research is multidisciplinary, incorporating elements of Biochemistry of Alzheimer's disease, P3 peptide and Cell biology. His research investigates the connection between Disease and topics such as Immunology that intersect with issues in Blood–brain barrier and Internal medicine.
Claudio Soto mostly deals with Virology, Disease, Protein folding, Biochemistry and Cell biology. His Virology research incorporates elements of Scrapie, Protein Misfolding Cyclic Amplification, Prion protein and Bovine spongiform encephalopathy. His research integrates issues of Transmission, In vitro and Cerebrospinal fluid in his study of Protein Misfolding Cyclic Amplification.
His work deals with themes such as Neuroscience, Immunology and In vivo, which intersect with Disease. His Protein folding research incorporates elements of PrPSc Proteins, Computational biology, Protein aggregation and Molecular mechanism. Claudio Soto combines subjects such as Transgene and Pathogenesis with his study of Cell biology.
His scientific interests lie mostly in Disease, Neuroscience, Pathology, Protein Misfolding Cyclic Amplification and Parkinson's disease. His work carried out in the field of Disease brings together such families of science as In vivo and Virology. His Infectivity study in the realm of Virology connects with subjects such as Hiv infected.
In general Neuroscience study, his work on Dopamine often relates to the realm of Traumatic brain injury, thereby connecting several areas of interest. His Protein Misfolding Cyclic Amplification study combines topics from a wide range of disciplines, such as Transmission, Bovine spongiform encephalopathy, Cerebrospinal fluid and Neurodegeneration. His research on Biochemistry focuses in particular on Protein folding.
His main research concerns Protein Misfolding Cyclic Amplification, Disease, Neuroscience, Infectivity and Neurodegeneration. His Protein Misfolding Cyclic Amplification research is multidisciplinary, incorporating elements of Cerebrospinal fluid, Oncology, Parkinson's disease, Transmission and Cell biology. His research integrates issues of Virus, Virology, Mesocricetus and Single-nucleotide polymorphism in his study of Disease.
His study in Infectivity is interdisciplinary in nature, drawing from both Toxicity, Protein engineering, Brain damage, In vivo and Gene isoform. His biological study spans a wide range of topics, including Scrapie, Bovine spongiform encephalopathy, Chaperone and Infectious agent. His Scrapie study deals with Protein aggregation intersecting with Protein structure and Protein folding.
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Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
Gabriela P. Saborio;Bruno Permanne;Claudio Soto.
Unfolding the role of protein misfolding in neurodegenerative diseases.
Nature Reviews Neuroscience (2003)
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.
Claudio Soto;Einar M. Sigurdsson;Laura Morelli;R. Asok Kumar.
Nature Medicine (1998)
In Vitro Generation of Infectious Scrapie Prions
Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto.
Converting a peptide into a drug: strategies to improve stability and bioavailability.
Celine Adessi;Claudio Soto.
Current Medicinal Chemistry (2002)
Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation
Claudio Soto;Mark S. Kindy;Marc Baumann;Blas Frangione.
Biochemical and Biophysical Research Communications (1996)
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.
C. Lasagna-Reeves;D. Gonzalez-Romero;D. Gonzalez-Romero;M. A. Barria;M. A. Barria;I. Olmedo;I. Olmedo.
Biochemical and Biophysical Research Communications (2010)
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
Shi Du Yan;Jin Fu;Claudio Soto;Xi Chen.
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
Claudio Hetz;Milene Russelakis‐Carneiro;Kinsey Maundrell;Joaquin Castilla.
The EMBO Journal (2003)
Protein misfolding and disease; protein refolding and therapy.
FEBS Letters (2001)
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