World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
97
Citations
36136
World Ranking
820
National Ranking
448

Biology and Biochemistry

D-Index
98
Citations
36369
World Ranking
1659
National Ranking
926

Overview

Claudio Soto is affiliated with The University of Texas Health Science Center at Houston in the United States. Their research focuses primarily on neurodegenerative diseases, with a substantial contribution to the understanding of molecular mechanisms underlying disorders such as Parkinson's disease and Alzheimer's disease.

The scientist has published extensively in fields related to Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, their work spans several subfields, including Neurology, Molecular Biology, Physiology, Cellular and Molecular Neuroscience, and Surgery.

Claudio Soto's research topics cover a variety of areas in neurological and neurodegenerative disease studies. Prominent topics include:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Prion Diseases and Protein Misfolding
  • Neurological disorders and treatments
  • Neurological diseases and metabolism
  • Botulinum Toxin and Related Neurological Disorders
  • Trace Elements in Health

The scientist has contributed to several frequent publication venues, reflecting their research impact and focus areas. These venues include:

  • Alzheimer s & Dementia
  • Acta Neuropathologica Communications
  • Cells
  • Frontiers in Aging Neuroscience
  • bioRxiv (Cold Spring Harbor Laboratory)

Among recent significant papers, the following publications are noted, with their respective years and publication sources:

  • Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy, 2020, Nature
  • Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study, 2023, The Lancet Neurology
  • A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research, 2024, The Lancet Neurology
  • High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease, 2021, Acta Neuropathologica Communications
  • Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid, 2023, Nature Protocols

The scientist collaborates frequently with several researchers, including:

  • Luis Concha-Marambio
  • Abhisek Mukherjee
  • Sandra Pritzkow
  • Inés Moreno-González
  • Mohammad Shahnawaz

Claudio Soto has also contributed to academic book literature. One such publication is:

  • Novel mechanisms involved in aging and neurodegeneration: Seeking potential therapeutic targets for neurodegenerative diseases., published by Frontiers Media in 2023

Best Publications

  • Unfolding the role of protein misfolding in neurodegenerative diseases.

    Claudio Soto

  • Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

    Gabriela P. Saborio;Bruno Permanne;Claudio Soto

  • Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

    Nibaldo C. Inestrosa;Alejandra Alvarez;Cristián A. Pérez;Ricardo D. Moreno

  • Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

    C Soto;E M Sigurdsson;L Morelli;R A Kumar

  • Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

    Claudio Soto;Sandra Pritzkow

  • In Vitro Generation of Infectious Scrapie Prions

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Hetz;Claudio Hetz;Claudio Soto

  • Converting a peptide into a drug: strategies to improve stability and bioavailability.

    Celine Adessi;Claudio Soto

  • Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

    Mohammad Shahnawaz;Abhisek Mukherjee;Sandra Pritzkow;Nicolas Mendez

  • Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.

    C. Lasagna-Reeves;D. Gonzalez-Romero;D. Gonzalez-Romero;M. A. Barria;M. A. Barria;I. Olmedo;I. Olmedo

  • Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation

    Claudio Soto;Mark S. Kindy;Marc Baumann;Blas Frangione

  • An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

    Shi Du Yan;Jin Fu;Claudio Soto;Xi Chen

  • Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

    Claudio Hetz;Milene Russelakis‐Carneiro;Kinsey Maundrell;Joaquin Castilla

  • Protein misfolding and disease; protein refolding and therapy.

    Claudio Soto

  • Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

    Mohammad Shahnawaz;Takahiko Tokuda;Masaaki Waragai;Nicolas Mendez

  • Inhibition of Alzheimer β-Fibrillogenesis by Melatonin

    Miguel Pappolla;Peter Bozner;Claudio Soto;Haiyan Shao

  • Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

    Shi Du Yan;Huaijie Zhu;Aiping Zhu;Adam Golabek

  • Production of cattle lacking prion protein.

    Jiirgen A. Richt;Poothappillai Kasinathan;Amir N. Hamir;Joaquin Castilla

  • Detection of prions in blood

    Joaquín Castilla;Paula Saá;Paula Saá;Claudio Soto

  • Protein misfolding and neurodegeneration.

    Claudio Soto;Lisbell D. Estrada;Lisbell D. Estrada

  • The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.

    Claudio Soto;Eduardo M. Castaño;Blas Frangione;Nibaldo C. Inestrosa

  • Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

    Claudio Soto;Richard J Kascsak;Gabriela P Saborío;Pierre Aucouturier

Frequent Co-Authors

Claudio Hetz
Claudio Hetz University of Chile
Blas Frangione
Blas Frangione New York University
Thomas Wisniewski
Thomas Wisniewski New York University
William A. Banks
William A. Banks University of Washington
Fabrizio Tagliavini
Fabrizio Tagliavini Istituto Neurologico Carlo Besta
Pierluigi Gambetti
Pierluigi Gambetti Case Western Reserve University
Frances Prelli
Frances Prelli New York University
Felipe A. Court
Felipe A. Court Buck Institute for Research on Aging
Nibaldo C. Inestrosa
Nibaldo C. Inestrosa Pontificia Universidad Católica de Chile

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