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Biology and Biochemistry
Switzerland
2026
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Medicine
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
140
Citations
75296
World Ranking
273
National Ranking
9

Medicine

D-Index
140
Citations
75186
World Ranking
1691
National Ranking
22

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2025 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2023 - Research.com Medicine in Switzerland Leader Award
  • 2022 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - Robert Koch Prize
  • 2001 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Pathology and Forensic Medicine
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Adriano Aguzzi is affiliated with the University of Zurich in Switzerland. Their body of research spans multiple fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine.

The scientist's research covers subfields such as molecular biology, neurology, infectious diseases, physiology, and cellular and molecular neuroscience. Their main topics of interest include prion diseases and protein misfolding, neurological diseases and metabolism, Alzheimer's disease research and treatments, SARS-CoV-2 and COVID-19 research, neuroinflammation and neurodegeneration mechanisms, trace elements in health, and COVID-19 clinical research studies.

Aguzzi's frequent publication venues reflect the interdisciplinary nature of their work and include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • EMBO Molecular Medicine
  • PLoS ONE
  • Neuron

Coauthorship is a significant aspect of Aguzzi's scientific activity. Frequent collaborators include:

  • Marc Emmenegger
  • Simone Hornemann
  • Karl Frontzek
  • Regina Reimann
  • Tuomas P. J. Knowles

Recent publications demonstrate a focus on neurological and immunological phenomena, including infectious disease responses and neurovascular regulation. Notable papers include:

  • "Persistent complement dysregulation with signs of thromboinflammation in active Long Covid," 2024, published in Science
  • "Microglia states and nomenclature: A field at its crossroads," 2022, Neuron
  • "Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19," 2020, Journal of Allergy and Clinical Immunology
  • "Pericytes regulate vascular immune homeostasis in the CNS," 2021, Proceedings of the National Academy of Sciences
  • "Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19," 2020, Neuropathology and Applied Neurobiology

Throughout their career, Aguzzi has received several recognitions, including the Robert Koch Prize in 2003. They were also named a Fellow of the American Association for the Advancement of Science (AAAS) in 2011. Additional honors include membership in the German National Academy of Sciences Leopoldina in the field of Pathology and Forensic Medicine and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Mice devoid of PrP are resistant to scrapie

    H. Büeler;A. Aguzzi;A. Sailer;R.-A. Greiner

  • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.

    Friedhelm Bladt;Dieter Riethmacher;Stefan Isenmann;Adriano Aguzzi

  • An analytical solution to the kinetics of breakable filament assembly

    Tuomas P. J. Knowles;Christopher A. Waudby;Glyn L. Devlin;Samuel I. A. Cohen

  • Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

    T J Cole;J A Blendy;A P Monaghan;K Krieglstein

  • Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

    M B Fischer;T Rülicke;A Raeber;A Sailer

  • Normal host prion protein necessary for scrapie-induced neurotoxicity

    Sebastian Brandner;Stefan Isenmann;Alex Raeber;Marek Fischer

  • Microglia: Scapegoat, Saboteur, or Something Else?

    Adriano Aguzzi;Ben A. Barres;Mariko L. Bennett

  • Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

    Frank L Heppner;Melanie Greter;Denis Marino;Jeppe Falsig

  • Protein aggregation diseases: pathogenicity and therapeutic perspectives

    Adriano Aguzzi;Tracy O'Connor

  • The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

    Bernardo S Franklin;Lukas Bossaller;Dominic De Nardo;Jacqueline M Ratter

  • Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

    Yi-Li Yang;L. F. L. Reis;J. Pavlovic;A. Aguzzi

  • Mammalian Prion Biology: One Century of Evolving Concepts

    Adriano Aguzzi;Magdalini Polymenidou

  • p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases

    Kurt Zatloukal;Cornelia Stumptner;Andrea Fuchsbichler;Hans Heid

  • The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice.

    Sabina Calogero;Fabio Grassi;Adriano Aguzzi;Till Voigtländer

  • Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

    B Adams;P Dörfler;A Aguzzi;Z Kozmik

  • Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

    Sabine Heber;Jochen Herms;Vladan Gajic;Johannes Hainfellner

  • Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

    Doron Shmerling;Ivan Hegyi;Marek Fischer;Thomas Blättler

  • A crucial role for B cells in neuroinvasive scrapie

    Michael A. Klein;Rico Frigg;Eckhard Flechsig;Alex J. Raeber

  • Prions: Protein Aggregation and Infectious Diseases

    Adriano Aguzzi;Anna Maria Calella

  • Experimental autoimmune encephalomyelitis repressed by microglial paralysis (vol 11, pg 146, 2005)

    FL Heppner;M Greter;D Marino;J Falsig

Frequent Co-Authors

Markus Glatzel
Markus Glatzel Universität Hamburg
Charles Weissmann
Charles Weissmann University of Florida
Sebastian Brandner
Sebastian Brandner University College London
Petra Schwarz
Petra Schwarz University of Zurich
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Marco Prinz
Marco Prinz University of Freiburg
Thomas Rülicke
Thomas Rülicke University of Veterinary Medicine Vienna
Christina J. Sigurdson
Christina J. Sigurdson University of California, San Diego
Rolf M. Zinkernagel
Rolf M. Zinkernagel University of Zurich
Herbert Budka
Herbert Budka Medical University of Vienna

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