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Medicine

D-Index
95
Citations
37240
World Ranking
9981
National Ranking
966

Overview

Sebastian Brandner is affiliated with University College London in the United Kingdom. Their research spans multiple fields related to medicine and molecular biology, with a total of 277 publications in Medicine and 120 in Biochemistry, Genetics, and Molecular Biology. The main research subfields include Genetics, Molecular Biology, Neurology, Radiology, Nuclear Medicine and Imaging, and Cancer Research.

Brandner's work focuses on specific topics such as:

  • Glioma Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Prion Diseases and Protein Misfolding
  • Meningioma and Schwannoma Management
  • Neurological Diseases and Metabolism
  • Cancer Genomics and Diagnostics
  • Neuroblastoma Research and Treatments

Frequent co-authors in Brandner's publications include:

  • Zane Jaunmuktane
  • Felix Sahm
  • Matija Snuderl
  • Philipp Sievers
  • Andreas von Deimling

Publication venues where Brandner has frequently contributed to include:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Nature Communications
  • Neuropathology and Applied Neurobiology

Among several published papers, notable recent examples are:

  • The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study (2022, The Lancet Neurology)
  • Sarcoma classification by DNA methylation profiling (2021, Nature Communications)
  • Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion (2021, Cell)
  • Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma (2021, Cancer Cell)
  • Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis (2020, Cell)

Best Publications

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

    M B Fischer;T Rülicke;A Raeber;A Sailer

  • Normal host prion protein necessary for scrapie-induced neurotoxicity

    Sebastian Brandner;Stefan Isenmann;Alex Raeber;Marek Fischer

  • Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

    Gaia Skibinski;Nicholas J Parkinson;Jeremy M Brown;Lisa Chakrabarti;Lisa Chakrabarti

  • Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

    Giovanna Mallucci;Andrew Dickinson;Jacqueline Linehan;Peter-Christian Klöhn

  • Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

    Ross Nortley;Nils Korte;Pablo Izquierdo;Chanawee Hirunpattarasilp

  • Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

    Doron Shmerling;Ivan Hegyi;Marek Fischer;Thomas Blättler

  • Monoclonal antibodies inhibit prion replication and delay the development of prion disease

    Anthony R. White;Perry Enever;Mourad Tayebi;Rosey Mushens

  • Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

    Zane Jaunmuktane;Simon Mead;Simon Mead;Matthew Ellis;Jonathan D. F. Wadsworth;Jonathan D. F. Wadsworth

  • An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

    Aideen O'Doherty;Sandra Ruf;Sandra Ruf;Claire Mulligan;Victoria Hildreth

  • Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report

    Stephen J Wroe;Suvankar Pal;Durrenajaf Siddique;Harpreet Hyare

  • Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

    L. Miguel Martins;L. Miguel Martins;Alastair Morrison;Kristina Klupsch;Valentina Fedele

  • Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma

    Jürgen A. Kraus;Jens Koopmann;Peter Kaskel;David Maintz

  • BEHAVIORAL AND ANATOMICAL DEFICITS IN MICE HOMOZYGOUS FOR A MODIFIED BETA -AMYLOID PRECURSOR PROTEIN GENE

    Ulrike Müller;Nadine Cristina;Zhi-Wei Li;David P. Wolfer

  • Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey

    Gill On;Spencer Y;Richard-Loendt A;Kelly C

  • Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.

    Laura D. Osellame;Ahad A. Rahim;Iain P. Hargreaves;Matthew E. Gegg;Matthew E. Gegg

  • Sarcoma classification by DNA methylation profiling

    Christian Koelsche;Christian Koelsche;Daniel Schrimpf;Daniel Schrimpf;Damian Stichel;Martin Sill

  • Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

    Sebastian Brandner;Alex Raeber;Andreas Sailer;Andreas Sailer;Thomas Blättler

  • PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain

    Thomas Blättler;Sebastian Brandner;Alex J. Raeber;Michael A. Klein

  • Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice

    Giovanna R. Mallucci;Melanie D. White;Michael Farmer;Andrew Dickinson

Frequent Co-Authors

John Collinge
John Collinge University College London
Adriano Aguzzi
Adriano Aguzzi University of Zurich
Andreas von Deimling
Andreas von Deimling Heidelberg University
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Simon Mead
Simon Mead University College London Hospitals NHS Foundation Trust
Felix Sahm
Felix Sahm University Hospital Heidelberg
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
David Capper
David Capper Charité - University Medicine Berlin
Charles Weissmann
Charles Weissmann University of Florida
Wolfgang Wick
Wolfgang Wick German Cancer Research Center

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