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Medicine

D-Index
90
Citations
50324
World Ranking
11966
National Ranking
1135

Overview

Simon Mead is affiliated with University College London Hospitals NHS Foundation Trust in the United Kingdom. Their research primarily focuses on molecular biology and medicine, with notable work spanning biochemistry, genetics, and neurology.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of their research encompass:

  • Molecular Biology
  • Neurology
  • Physiology
  • Psychiatry and Mental health
  • Genetics

Simon Mead has contributed extensively to topics such as:

  • Prion Diseases and Protein Misfolding
  • Alzheimer's disease research and treatments
  • Neurological diseases and metabolism
  • Amyotrophic Lateral Sclerosis Research
  • Dementia and Cognitive Impairment Research
  • Trace Elements in Health
  • RNA Research and Splicing

The scientist has published notable papers including:

  • Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease, 2021, The Lancet Neurology
  • Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study, 2020, Molecular Psychiatry
  • Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa, 2020, The American Journal of Human Genetics
  • Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon, 2022, Journal of Neurology Neurosurgery & Psychiatry
  • Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone, 2024, Nature Medicine

Frequent co-authors associated with Simon Mead include:

  • John Collinge
  • Jonathan D. Rohrer
  • Nick C. Fox
  • Sebastian Brandner
  • Akın Nihat

The scientist's work has been published repeatedly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • The Lancet Neurology
  • Journal of Neurology Neurosurgery & Psychiatry
  • Acta Neuropathologica

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

    Elisa Majounie;Alan E. Renton;Kin Mok;Elise G. P. Dopper;Elise G. P. Dopper

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Lesley Jones;Peter A. Holmans;Marian L. Hamshere;Denise Harold

  • The heritability and genetics of frontotemporal lobar degeneration

    J.D. Rohrer;R. Guerreiro;J. Vandrovcova;J. Uphill

  • Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

    Jonathan D Rohrer;Jennifer M Nicholas;Jennifer M Nicholas;David M Cash;John van Swieten

  • Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

    Zane Jaunmuktane;Simon Mead;Simon Mead;Matthew Ellis;Jonathan D. F. Wadsworth;Jonathan D. F. Wadsworth

  • A stop-codon mutation in the BRI gene associated with familial British dementia

    Ruben Vidal;Blas Frangione;Agueda Rostagno;Simon Mead

  • Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

    Ian T.S. Coyle-Gilchrist;Katrina M. Dick;Karalyn Patterson;Patricia Vázquez Rodríquez

  • Kuru in the 21st century—an acquired human prion disease with very long incubation periods

    John Collinge;Jerome Whitfield;Jerome Whitfield;Edward McKintosh;John Beck

  • Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features

    Colin J. Mahoney;Jon Beck;Jonathan D. Rohrer;Tammaryn Lashley

  • Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics.

    Simon Mead;Michael P. H. Stumpf;Jerome Whitfield;Jonathan A. Beck

  • Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia

    Jonathan D. Rohrer;Ione O.C. Woollacott;Katrina M. Dick;Emilie Brotherhood

  • Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.

    Jon Beck;Mark Poulter;Davina Hensman;Jonathan D. Rohrer

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

John Collinge
John Collinge University College London
Nick C. Fox
Nick C. Fox University College London
Martin N. Rossor
Martin N. Rossor University College London
Jonathan D. Rohrer
Jonathan D. Rohrer University College London
Jason D. Warren
Jason D. Warren University College London
John Hardy
John Hardy University College London
Jonathan M. Schott
Jonathan M. Schott University College London
Sebastian Brandner
Sebastian Brandner University College London
Rita Guerreiro
Rita Guerreiro Van Andel Institute
Tamas Revesz
Tamas Revesz University College London

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