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Biology and Biochemistry

D-Index
47
Citations
9278
World Ranking
18649
National Ranking
7629

Overview

O. M. Zack Howard is a researcher affiliated with the National Institutes of Health in the United States. Their academic contributions span the fields of Immunology and Microbiology as well as Medicine, reflecting a multidisciplinary approach within biological and health sciences.

Their work primarily addresses areas including inflammation biomarkers and pathways, inflammatory biomarkers in disease prognosis, RNA interference and gene delivery, viral infections and immunology research, and immune cell function and interaction. These topics suggest a focus on cellular and molecular mechanisms underpinning immune responses and disease progression.

Howard's publication record includes research in notable venues such as Frontiers in Oncology and UNC Libraries. Key recent papers include:

  • "Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma," published in 2022 in Frontiers in Oncology
  • "Human Ribonuclease A Superfamily Members, Eosinophil-Derived Neurotoxin and Pancreatic Ribonuclease, Induce Dendritic Cell Maturation and Activation," published in 2020 in UNC Libraries

Collaboration is evident in Howard's work, with frequent coauthors including Jill Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, and Jeffrey Subleski. This network spans multiple studies and indicates ongoing partnerships in their research endeavors.

The constellation of their research publications underlines activity within subfields such as Immunology, Oncology, Molecular Biology, and Cardiology and Cardiovascular Medicine. This variety reinforces the interdisciplinary nature of their scientific investigation.

Best Publications

  • Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells: In Vivo Neovascularization Induced by Stromal-Derived Factor-1α

    Rosalba Salcedo;Ken Wasserman;Howard A. Young;Michael C. Grimm

  • Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

    Xin Chen;Monika Bäumel;Daniela N. Männel;O. M. Zack Howard

  • Cellular pharmacology studies of shikonin derivatives.

    Xin Chen;Lu Yang;Joost J. Oppenheim;O. M. Zack Howard

  • Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells

    Riccardo Bertini;O.M. Zack Howard;Hui-Fang Dong;Joost J. Oppenheim

  • Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

    Xin Chen;Jeffrey J. Subleski;Heather Kopf;O. M. Zack Howard

  • Histidyl–tRNA Synthetase and Asparaginyl–tRNA Synthetase, Autoantigens in Myositis, Activate Chemokine Receptors on T Lymphocytes and Immature Dendritic Cells

    O.M. Zack Howard;Hui Fang Dong;De Yang;Nina Raben

  • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

    Heather Kopf;Gonzalo M. de la Rosa;O.M.Zack Howard;Xin Chen

  • TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

    Xin Chen;Xueqiang Wu;Qiong Zhou;O. M. Zack Howard

  • Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1

    Xin Chen;Lu Yang;Ning Zhang;Jim A. Turpin

  • Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.

    Xin Chen;Joost J Oppenheim;Robin T Winkler-Pickett;John R Ortaldo

  • Differential response of murine CD4+CD25+ and CD4+CD25– T cells to dexamethasone‐induced cell death

    Xin Chen;Takaya Murakami;Joost J. Oppenheim;O. M. Zack Howard

  • Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood

    Xin Chen;Jeffrey J. Subleski;Ryoko Hamano;O. M. Zack Howard

  • Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15

    Ronald Wolf;O. M. Zack Howard;Hui-Fang Dong;Christopher Voscopoulos

  • Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication

    Wanghua Gong;O.M. Zack Howard;Jim A. Turpin;Michael C. Grimm

  • Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.

    Jia Qi;Krisztina Buzas;Huiting Fan;Jeffrey I. Cohen

  • Formylpeptide Receptor FPR and the Rapid Growth of Malignant Human Gliomas

    Ye Zhou;Xiuwu Bian;Yingying Le;Wanghua Gong

  • BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25− responder T cells than C57BL/6 mice

    Xin Chen;Joost J. Oppenheim;O. M. Zack Howard

  • Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

    Xin Chen;Ryoko Hamano;Jeffrey J. Subleski;Arthur A. Hurwitz

  • Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells

    Xin Chen;Robin T. Winkler-Pickett;Nicholas H. Carbonetti;John R. Ortaldo

  • Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.

    De Yang;Qian Chen;Helene F. Rosenberg;Susanna M. Rybak

Frequent Co-Authors

Joost J. Oppenheim
Joost J. Oppenheim National Institutes of Health
Xin Chen
Xin Chen University of Macau
Ji Ming Wang
Ji Ming Wang National Institutes of Health
De Yang
De Yang National Cancer Research Institute, UK
Wanghua Gong
Wanghua Gong Leidos (United States)
Howard A. Young
Howard A. Young National Institutes of Health
Paul H. Plotz
Paul H. Plotz National Institutes of Health
Akihiro Matsukawa
Akihiro Matsukawa Okayama University
Xiu-Wu Bian
Xiu-Wu Bian Third Military Medical University
Stuart H. Yuspa
Stuart H. Yuspa National Institutes of Health

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