Xin Chen

Overview

Best Publications

• Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective.

  Yang Yang;Shahidul Islam;Jin Wang;Yuan Li

  989
  Citations

• Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts.

  Jin Wang;Mengmeng Jiang;Xin Chen;Luis J. Montaner

  753
  Citations

• Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

  Xin Chen;Monika Bäumel;Daniela N. Männel;O. M. Zack Howard

  647
  Citations

• Cellular pharmacology studies of shikonin derivatives.

  Xin Chen;Lu Yang;Joost J. Oppenheim;O. M. Zack Howard

  488
  Citations

• Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

  Xin Chen;Jeffrey J. Subleski;Heather Kopf;O. M. Zack Howard

  380
  Citations

• Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

  Ping Li;Ying Zheng;Xin Chen

  361
  Citations

• Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

  Heather Kopf;Gonzalo M. de la Rosa;O.M.Zack Howard;Xin Chen

  321
  Citations

• TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

  Xin Chen;Xueqiang Wu;Qiong Zhou;O. M. Zack Howard

  319
  Citations

• Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1

  Xin Chen;Lu Yang;Ning Zhang;Jim A. Turpin

  311
  Citations

• Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.

  Xin Chen;Joost J Oppenheim;Robin T Winkler-Pickett;John R Ortaldo

  288
  Citations

• Differential response of murine CD4+CD25+ and CD4+CD25– T cells to dexamethasone‐induced cell death

  Xin Chen;Takaya Murakami;Joost J. Oppenheim;O. M. Zack Howard

  282
  Citations

• Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood

  Xin Chen;Jeffrey J. Subleski;Ryoko Hamano;O. M. Zack Howard

  237
  Citations

• Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells

  Xin Chen;Joost J. Oppenheim

  180
  Citations

• BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25− responder T cells than C57BL/6 mice

  Xin Chen;Joost J. Oppenheim;O. M. Zack Howard

  167
  Citations

• Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

  Renata Mazzucchelli;Julie A. Hixon;Rosanne Spolski;Xin Chen

  167
  Citations

• Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

  Xin Chen;Ryoko Hamano;Jeffrey J. Subleski;Arthur A. Hurwitz

  154
  Citations

• Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells

  Xin Chen;Robin T. Winkler-Pickett;Nicholas H. Carbonetti;John R. Ortaldo

  154
  Citations

• TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells

  Xin Chen;Joost J. Oppenheim

  140
  Citations

• Th17 cells and Tregs: unlikely allies.

  Xin Chen;Joost J. Oppenheim

  134
  Citations

• Pertussis Toxin by Inducing IL-6 Promotes the Generation of IL-17-Producing CD4 Cells

  Xin Chen;O. M. Zack Howard;Joost J. Oppenheim

  132
  Citations

• Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

  Xin Chen;Joost J. Oppenheim

  123
  Citations