Roman Fischer

Overview

Best Publications

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

  Evanna L Mills;Dylan G Ryan;Hiran A Prag;Dina Dikovskaya

  1783
  Citations

• Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

  Roman Fischer;Olaf Maier

  657
  Citations

• Colonic epithelial cell diversity in health and inflammatory bowel disease

  Kaushal Parikh;Kaushal Parikh;Agne Antanaviciute;Agne Antanaviciute;David Fawkner-Corbett;David Fawkner-Corbett;David Fawkner-Corbett;Marta Jagielowicz;Marta Jagielowicz

  634
  Citations

• Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

  Julie Adam;Emine Hatipoglu;Linda O'Flaherty;Nicola Ternette

  621
  Citations

• A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

  Fahu Chen;Fahu Chen;Frido Welker;Frido Welker;Frido Welker;Chuan Chou Shen;Shara E. Bailey;Shara E. Bailey

  477
  Citations

• The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.

  Alexander Hooftman;Stefano Angiari;Svenja Hester;Sarah E. Corcoran

  405
  Citations

• Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

  Mikael Altun;Holger B. Kramer;Lianne I. Willems;Jeffrey L. McDermott

  387
  Citations

• Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates

  Frido Welker;Matthew J. Collins;Jessica A. Thomas;Marc Wadsley

  377
  Citations

• 53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

  Hind Ghezraoui;Catarina Oliveira;Jordan R. Becker;Kirstin Bilham

  323
  Citations

• Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

  G Kochan;T Krojer;D Harvey;R Fischer

  291
  Citations

• Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne

  Frido Welker;Frido Welker;Mateja Hajdinjak;Sahra Talamo;Klervia Jaouen

  279
  Citations

• Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

  Elizabeth Haythorne;Maria Rohm;Martijn van de Bunt;Martijn van de Bunt;Melissa F. Brereton

  264
  Citations

• Protein sequences bound to mineral surfaces persist into deep time.

  Beatrice Demarchi;Shaun Hall;Teresa Roncal-Herrero;Colin Freeman

  254
  Citations

• Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

  Jade D. Bailey;Marina Diotallevi;Thomas Nicol;Eileen McNeill

  240
  Citations

• Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

  Bruno Vaz;Marta Popovic;Joseph A. Newman;John Fielden

  237
  Citations

• Direct evidence of milk consumption from ancient human dental calculus

  C Warinner;J Hendy;C Speller;E Cappellini

  219
  Citations

• Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

  A. E. Yuzhalin;A. N. Gordon-Weeks;M. L. Tognoli;K. Jones

  186
  Citations

• Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

  Roman Fischer;Roland E Kontermann;Klaus Pfizenmaier

  172
  Citations

• Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

  Nicola Ternette;Ming Yang;Mahima Laroyia;Mitsuhiro Kitagawa

  165
  Citations

• Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.

  Fabrizio Miranda;David Mannion;Shujuan Liu;Yiyan Zheng

  164
  Citations