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Immunology

D-Index
61
Citations
13438
World Ranking
3235
National Ranking
279

Overview

Paul Bowness is affiliated with the University of Oxford in the United Kingdom. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a significant concentration in the subfields of Rheumatology, Immunology, Hematology, Molecular Biology, and Infectious Diseases. This focus is reflected in the extensive body of work investigating autoimmune and inflammatory disorders as well as infectious diseases.

The scientist's scholarly contributions cover a range of topics including:

  • Spondyloarthritis Studies and Treatments
  • Psoriasis: Treatment and Pathogenesis
  • Autoimmune and Inflammatory Disorders Research
  • Rheumatoid Arthritis Research and Therapies
  • T-cell and B-cell Immunology
  • Systemic Lupus Erythematosus Research
  • COVID-19 Clinical Research Studies

Paul Bowness has published numerous articles in various academic venues. The most frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of the Rheumatic Diseases
  • Zenodo (CERN European Organization for Nuclear Research)
  • Frontiers in Immunology
  • Lara D. Veeken

Among the recent notable papers authored or co-authored by Paul Bowness are:

  • "A blood atlas of COVID-19 defines hallmarks of disease severity and specificity," 2022, published in Cell
  • "An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease," 2021, published in Nature Immunology
  • "Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis," 2020, published in Nature Communications
  • "Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides," 2022, published in Nature
  • "New developments in our understanding of ankylosing spondylitis pathogenesis," 2020, published in Immunology

The scientist frequently collaborates with other researchers. Their most common co-authors include:

  • Julian C. Knight
  • Frank Penkava
  • Hai Fang
  • Hussein Al-Mossawi
  • Andrew Brown

Best Publications

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D M Evans;Spencer Cca.;J J Pointon;Z Su

  • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

    A Cortes;J Hadler;J P Pointon

  • CD56bright Human NK Cells Differentiate Into CD56dim Cells: Role of Contact With Peripheral Fibroblasts

    Antoni Chan;Deng-Li Hong;Ann Atzberger;Simon Kollnberger

  • A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

    Unknown

  • Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.

    Eva Billerbeck;Yu Hoi Kang;Lucy Walker;Helen Lockstone

  • Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure.

    Rachel L. Allen;Chris A. O’Callaghan;Andrew J. McMichael;Paul Bowness

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D.M. Evans;C.C.A. Spencer;J.J. Pointon;Z. Su

  • Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis.

    Paul Bowness;Anna Ridley;Jacqueline Shaw;Antoni T. Chan;Antoni T. Chan

  • Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

    Adrian Cortes;Sara L. Pulit;Paul J. Leo;Jenny J. Pointon

  • Cell‐surface expression and immune receptor recognition of HLA–B27 homodimers

    Simon Kollnberger;Lucy Bird;Mei-Yi Sun;Christelle Retiere

  • Hereditary C1q deficiency and systemic lupus erythematosus.

    P. Bowness;K.A. Davies;P.J. Norsworthy;P. Athanassiou

  • Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

    G Kochan;T Krojer;D Harvey;R Fischer

  • CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

    Ariane Hammitzsch;Cynthia Tallant;Oleg Fedorov;Alison O’Mahony

  • Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

    Lucy A Bird;Chen Au Peh;Simon Kollnberger;Tim Elliott

  • Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis

    A T Chan;S D Kollnberger;L R Wedderburn;P Bowness

  • A genetics-led approach defines the drug target landscape of 30 immune-related traits

    H Fang;H De Wolf;B Knezevic;K L Burnham

  • A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

    T Schwerd;Twigg Srf.;D Aschenbrenner;S Manrique

  • Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

    Unknown

  • An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

    Yanchun Peng;Suet Ling Felce;Danning Dong;Danning Dong;Frank Penkava

  • Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

    Eva Dazert;Christoph Neumann-Haefelin;Stéphane Bressanelli;Karen Fitzmaurice

  • Identification of HLA-B27-Restricted Peptides from the Chlamydia trachomatis Proteome with Possible Relevance to HLA-B27-Associated Diseases

    Wolfgang Kuon;Hermann-Georg Holzhütter;Heiner Appel;Martina Grolms

  • Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.

    Frank Penkava;Martin Del Castillo Velasco-Herrera;Matthew D. Young;Nicole Yager

  • HLA-B27 Heavy Chain Homodimers Are Expressed in HLA-B27 Transgenic Rodent Models of Spondyloarthritis and Are Ligands for Paired Ig-Like Receptors

    Simon Kollnberger;Lucy A. Bird;Matthew Roddis;Cecile Hacquard-Bouder

  • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

    A. Cortes;J. Hadler;J.P. Pointon;P.C. Robinson

Frequent Co-Authors

Andrew J. McMichael
Andrew J. McMichael University of Oxford
Paul Klenerman
Paul Klenerman University of Oxford
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Julian C. Knight
Julian C. Knight University of Oxford
Jaakko Tuomilehto
Jaakko Tuomilehto University of Helsinki
David Evans
David Evans University of Bristol
Matthew A. Brown
Matthew A. Brown Guy's and St Thomas' NHS Foundation Trust
Roman Fischer
Roman Fischer University of Oxford
Robert D. Inman
Robert D. Inman University of Toronto
Maxime Breban
Maxime Breban University of Paris-Saclay

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