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Immunology

D-Index
87
Citations
32560
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1203
National Ranking
76

Medicine

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Citations
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Research.com Recognitions

  • 2020 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Internal Medicine and Dermatology

Overview

Robert Thimme is a researcher affiliated with the University of Freiburg in Germany. Their work primarily spans the field of Medicine with a focus on Hepatology, Epidemiology, Immunology, Surgery, and Infectious Diseases.

The main topics of Robert Thimme's research include:

  • Liver Disease Diagnosis and Treatment
  • Hepatitis C virus research
  • Liver Disease and Transplantation
  • Hepatitis B Virus Studies
  • Immune Cell Function and Interaction
  • Hepatocellular Carcinoma Treatment and Prognosis
  • SARS-CoV-2 and COVID-19 Research

Frequent co-authors in Thimme's publications are:

  • Maike Hofmann
  • Dominik Bettinger
  • Christoph Neumann-Haefelin
  • Bertram Bengsch
  • Michael Schultheiß

Robert Thimme has contributed extensively to scientific journals, often publishing in:

  • Zeitschrift für Gastroenterologie
  • Journal of Hepatology
  • DMW - Deutsche Medizinische Wochenschrift
  • Gastro-News
  • Gut

Recent notable papers by Robert Thimme include:

  • "Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH" (2021, Nature)
  • "Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine" (2021, Nature)
  • "Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells" (2020, Nature Medicine)
  • "Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions" (2021, Immunity)
  • "Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants" (2021, Nature Communications)

In recognition of their contributions to internal medicine and dermatology, Robert Thimme was awarded membership in the German National Academy of Sciences Leopoldina in 2020.

Best Publications

  • Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

    Robert Thimme;David Oldach;Kyong Mi Chang;Kyong Mi Chang;Carola Steiger

  • CD8+ T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

    Robert Thimme;Stefan Wieland;Carola Steiger;John Ghrayeb

  • Genomic analysis of the host response to hepatitis C virus infection.

    Andrew I. Su;John P. Pezacki;Lisa Wodicka;Amy D. Brideau

  • T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections

    Daniel T. Utzschneider;Mélanie Charmoy;Vijaykumar Chennupati;Laurène Pousse

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

    Desireé Schubert;Desireé Schubert;Claudia Bode;Rupert Kenefeck;Tie Zheng Hou

  • Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

    Robert Thimme;Jens Bukh;Hans Christian Spangenberg;Stefan Wieland

  • TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

    Francesca Alfei;Kristiyan Kanev;Maike Hofmann;Ming Wu

  • Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

    Cedric Vonarbourg;Arthur Mortha;Viet L. Bui;Viet L. Bui;Pedro P. Hernandez;Pedro P. Hernandez

  • Genomic analysis of the host response to hepatitis B virus infection.

    Unknown

  • T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection

    Tobias Boettler;Hans Christian Spangenberg;Christoph Neumann-Haefelin;Elisabeth Panther

  • A global scientific strategy to cure hepatitis B

    Peter A Revill;Francis V Chisari;Joan M Block;Maura Dandri

  • A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

    Johannes Haybaeck;Nicolas Zeller;Monika Julia Wolf;Achim Weber

  • Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

    Bertram Bengsch;Bianca Seigel;Marianne Ruhl;Jörg Timm

  • Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASH

    Michael Dudek;Dominik Pfister;Sainitin Donakonda;Pamela Filpe

  • Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection☆

    Kyong-Mi Chang;Kyong-Mi Chang;Robert Thimme;Jacqueline J. Melpolder;David Oldach

  • Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.

    Eva Billerbeck;Yu Hoi Kang;Lucy Walker;Helen Lockstone

  • The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma.

    David J. Pinato;Rohini Sharma;Elias Allara;Clarence Yen

  • Rapid and stable mobilization of CD8 + T cells by SARS-CoV-2 mRNA vaccine.

    Valerie Oberhardt;Hendrik Luxenburger;Janine Kemming;Isabel Schulien

  • Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma

    Tobias Flecken;Nathalie Schmidt;Sandra Hild;Emma Gostick

  • Characterization of pre-existing and induced SARS-CoV-2-specific CD8 + T cells.

    Isabel Schulien;Janine Kemming;Valerie Oberhardt;Katharina Wild

  • Innate and adaptive immune responses in HCV infections

    Markus H. Heim;Markus H. Heim;Robert Thimme

  • Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

    Yuchen Xia;Daniela Stadler;Julie Lucifora;Florian Reisinger

  • Pathogenesis of hepatitis B virus infection.

    Thomas F Baumert;Robert Thimme;Fritz von Weizsäcker

  • Natural history of chronic hepatitis B virus infection

    Katrin Busch;Robert Thimme

Frequent Co-Authors

Hubert E. Blum
Hubert E. Blum University of Freiburg
Christoph Neumann-Haefelin
Christoph Neumann-Haefelin University of Freiburg
Paul Klenerman
Paul Klenerman University of Oxford
David Price
David Price University of Aberdeen
Ralf Bartenschlager
Ralf Bartenschlager Heidelberg University
Michael Roggendorf
Michael Roggendorf Technical University of Munich
Volker Lohmann
Volker Lohmann Heidelberg University
Thomas F. Baumert
Thomas F. Baumert University of Strasbourg
Francis V. Chisari
Francis V. Chisari Scripps Research Institute
Georg M. Lauer
Georg M. Lauer Harvard University

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