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Immunology

D-Index
61
Citations
12067
World Ranking
3258
National Ranking
280

Overview

Tomáš Hanke is affiliated with the University of Oxford in the United Kingdom. Their research primarily focuses on immunology, microbiology, and medicine, with a significant concentration on virology, immunology, infectious diseases, molecular biology, and epidemiology. This multidisciplinary approach supports investigations into viral infections, immune responses, and therapies.

Their work covers important topics including HIV research and treatment, vaccines and immunoinformatics approaches, immune cell function and interaction, HIV/AIDS research and interventions, HIV/AIDS drug development and treatment, virus-based gene therapy research, and studies on cytomegalovirus and herpesvirus.

Hanke has contributed extensively to the scientific literature, with notable recent publications such as:

  • Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial (2020), published in The Lancet
  • HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02) (2020), published in Frontiers in Immunology
  • Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial (2022), published in Nature Medicine
  • Gut microbiome signatures linked to HIV-1 reservoir size and viremia control (2022), published in Microbiome
  • MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans (2020), published in Science Translational Medicine

Frequent collaborators in Hanke's research include Edmund G. Wee, Christian Brander, Alison Crook, Lucy Dorrell, and Beatriz Mothe.

Hanke's research has been published repeatedly in certain venues, which include:

  • Vaccines
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • npj Vaccines
  • The Lancet Microbe

The scientist's work integrates aspects of immunology and microbiology with medicine, producing insights relevant to HIV/AIDS treatment and vaccine development. Their contributions span both clinical trials and immunological studies, shaping understanding of viral reservoirs, vaccine safety and immunogenicity, and immune system interactions in the context of viral infections.

Best Publications

  • Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

    Jörg Schneider;Sarah C. Gilbert;Tom J. Blanchard;Tomas Hanke

  • Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

    Tomas Hanke;Rachel V. Samuel;Tom J. Blanchard;Veronica C. Neumann

  • Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen

    Todd M. Allen;Thorsten U. Vogel;Deborah H. Fuller;Bianca R. Mothé

  • HIV vaccines 1983-2003.

    Andrew J McMichael;Tomas Hanke

  • Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+ T-Cell Epitopes

    Nilu Goonetilleke;Stephen Moore;Len Dally;Nicola Winstone

  • Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine

    Sven Létourneau;Eung-Jun Im;Tumelo Mashishi;Choechoe Brereton

  • Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

    Tomás Hanke;T J Blanchard;J Schneider;Carolyn M Hannan

  • A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans.

    Matilu Mwau;Inese Cebere;Julian Sutton;Priscilla Chikoti

  • Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya.

    Tomas Hanke;Andrew J. McMichael

  • Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1

    Nicola Borthwick;Tina Ahmed;Beatrice Ondondo;Peter Hayes

  • Crystal structure of a soluble CD28-Fab complex

    E J Evans;R M Esnouf;R Manso-Sancho;Gilbert Rjc.

  • Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen.

    Tomas Hanke;Paul Szawlowski;Richard E. Randall

  • DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

    Tomáš Hanke;Jörg Schneider;Sarah C. Gilbert;Adrian V.S. Hill

  • Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers.

    Inese Cebere;Lucy Dorrell;Helen McShane;Alison Simmons

  • Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1

    Louise A Johnson;Suneale Banerji;William Lawrance;Uzi Gileadi

  • The quest for an AIDS vaccine: is the CD8 + T-cell approach feasible?

    Andrew McMichael;Tomâs Hanke

  • Clinical experience with plasmid DNA- and modified vaccinia virus Ankara-vectored human immunodeficiency virus type 1 clade A vaccine focusing on T-cell induction

    Tomáš Hanke;Nilu Goonetilleke;Andrew J. McMichael;Lucy Dorrell

  • Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS.

    Tomáš Hanke;Andrew McMichael

  • Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime.

    Tomáš Hanke;Veronica C Neumann;Tom J Blanchard;Paul Sweeney

  • Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: Effects of dosage and route on safety and immunogenicity

    Barry S. Peters;Walter Jaoko;Eftyhia Vardas;George Panayotakopoulos

Frequent Co-Authors

Andrew J. McMichael
Andrew J. McMichael University of Oxford
Geoffrey L. Smith
Geoffrey L. Smith University of Oxford
Bette T. Korber
Bette T. Korber Los Alamos National Laboratory
Tao Dong
Tao Dong University of Oxford
Sarah Rowland-Jones
Sarah Rowland-Jones University of Sheffield
Magdalena Plebanski
Magdalena Plebanski RMIT University
Walter Jaoko
Walter Jaoko University of Nairobi
Alfredo Nicosia
Alfredo Nicosia University of Naples Federico II
Christopher P. Conlon
Christopher P. Conlon University of Oxford
John Frater
John Frater University of Oxford

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