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Immunology

D-Index
89
Citations
24237
World Ranking
1129
National Ranking
40

Overview

Dominique Baeten is affiliated with the University of Amsterdam in the Netherlands. Their research interests span several domains within medicine, particularly focusing on immunology and microbiology, with significant contributions to rheumatology and autoimmune disorders.

The scientist has contributed extensively to the study of inflammatory and autoimmune conditions. Their research covers key topics such as:

  • Spondyloarthritis Studies and Treatments
  • Psoriasis: Treatment and Pathogenesis
  • Rheumatoid Arthritis Research and Therapies
  • Autoimmune and Inflammatory Disorders Research
  • T-cell and B-cell Immunology
  • IL-33, ST2, and ILC Pathways
  • Systemic Lupus Erythematosus Research

Dominique Baeten's published work includes papers on the roles of interleukins and immune cell activity in inflammatory diseases, with a focus on innovative treatments involving dual neutralisation of immune mediators. Notable recent publications include:

  • Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa, 2021, JAMA Dermatology
  • Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study, 2020, Annals of the Rheumatic Diseases
  • Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis, 2020, Science Translational Medicine
  • Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling, 2020, Frontiers in Immunology
  • Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells, 2020, RMD Open

Frequent co-authors in Baeten's publications include:

  • Stevan Shaw
  • Sander W. Tas
  • M. G. H. Van de Sande
  • Nataliya Yeremenko
  • Leonie M. van Duivenvoorde

The scientist commonly publishes in the following venues:

  • Frontiers in Immunology
  • Annals of the Rheumatic Diseases
  • International Journal of Molecular Sciences
  • The Journal of Immunology
  • Arthritis & Rheumatology

Dominique Baeten's work is mainly situated within the fields of medicine and immunology and microbiology, with over fifty publications in medicine and nearly thirty in immunology and microbiology. Their subfield expertise includes rheumatology, immunology, hematology, dermatology, and imaging sciences.

Best Publications

  • Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

    Dominique Baeten;Joachim Sieper;Jürgen Braun;Xenofon Baraliakos

  • Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

    Dominique Baeten;Xenofon Baraliakos;Jürgen Braun;Joachim Sieper

  • Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis

    Jasper J. Haringman;Danielle M. Gerlag;Aeilko H. Zwinderman;Tom J.M. Smeets

  • Arthritis 2 Spondyloarthritis

    Maxime Dougados;Dominique Baeten

  • Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.

    C.A. Ambarus;S. Krausz;M. van der Eijk;J. Hamann

  • Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (infliximab) versus placebo in active spondylarthropathy.

    Filip Van den Bosch;Elli Kruithof;Dominique Baeten;Annemie Herssens

  • Myelin oligodendrocyte glycoprotein–specific T and B cells cooperate to induce a Devic-like disease in mice

    Estelle Bettelli;Dominique Baeten;Anneli Jäger;Raymond A. Sobel

  • Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study

    F Van den Bosch;E Kruithof;D Baeten;F De Keyser

  • Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance

    Sophie Brouard;Elaine Mansfield;Christophe Braud;Li Li

  • Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study.

    Dominique Baeten;Mikkel Østergaard;James Cheng-Chung Wei;Joachim Sieper

  • Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis

    Elli Kruithof;Dominique Lp Baeten;Leen De Rycke;Bernard Vandooren

  • Ankylosing spondylitis and bowel disease

    Dominique Baeten;Filip De Keyser;Herman Mielants;Eric M Veys

  • Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis.

    Troy Noordenbos;Nataliya Yeremenko;Ioana Gofita;Marleen van de Sande

  • Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis

    Janneke J. de Winter;Leonieke J. van Mens;Désirée van der Heijde;Robert Landewé

  • Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study

    Jürgen Braun;Xenofon Baraliakos;Atul Deodhar;Dominique Baeten

  • Modulation of CCR2 in rheumatoid arthritis - A double-blind, randomized, placebo-controlled clinical trial

    Clarissa E. Vergunst;Daniëlle M. Gerlag;Luba Lopatinskaya;L. Klareskog

  • A randomized controlled trial with an anti-CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

    Jasper J. Haringman;Danielle M. Gerlag;Tom J. M. Smeets;Dominique Baeten;Dominique Baeten

  • Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation.

    Sophie Glatt;Dominique Baeten;Terry Baker;Meryn Griffiths

  • Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study.

    Dominique Baeten;Dominique Baeten;Elli Kruithof;Filip Van den Bosch;Pieter Demetter

  • Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: Relevance to antifilaggrin autoantibodies

    Dominique Baeten;Isabelle Peene;Ann Union;Lydie Meheus

  • Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab: a new perspective on the role of host defence in the pathogenesis of the disease?

    D Baeten;E Kruithof;F Van den Bosch;N Van den Bossche

Frequent Co-Authors

Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Eric Veys
Eric Veys Ghent University Hospital
Filip De Keyser
Filip De Keyser Ghent University Hospital
Robert Landewé
Robert Landewé University of Amsterdam
Herman Mielants
Herman Mielants Ghent University Hospital
Paul Emery
Paul Emery University of Leeds
Dirk Elewaut
Dirk Elewaut Ghent University
Danielle M. Gerlag
Danielle M. Gerlag UCB Pharma (United Kingdom)
Hergen Spits
Hergen Spits University of Amsterdam
Joachim Sieper
Joachim Sieper Charité - University Medicine Berlin

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