World's Best Scientists 2026 revealed!
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Immunology
Netherlands
2026

D-Index & Metrics

Immunology

D-Index
124
Citations
62481
World Ranking
296
National Ranking
9

Medicine

D-Index
125
Citations
62649
World Ranking
3079
National Ranking
117

Research.com Recognitions

  • 2026 - Research.com Immunology in Netherlands Leader Award
  • 2025 - Research.com Immunology in Netherlands Leader Award

Overview

Hergen Spits is affiliated with the University of Amsterdam in the Netherlands and conducts research primarily in the fields of Immunology and Microbiology as well as Medicine. Their work spans several key areas of immunological science, including the study of immune cell functions, interactions, and responses.

The scientist's research prominently covers main topics such as:

  • IL-33, ST2, and ILC Pathways
  • Immune Cell Function and Interaction
  • Eosinophilic Esophagitis
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • T-cell and B-cell Immunology
  • Allergic Rhinitis and Sensitization

In terms of subfields, their work extensively involves:

  • Immunology
  • Surgery
  • Radiology, Nuclear Medicine and Imaging
  • Immunology and Allergy
  • Oncology

Hergen Spits has several recent publications demonstrating contributions to the understanding of innate lymphoid cells and immunotherapy. Notable examples include:

  • "Plasticity of innate lymphoid cell subsets," 2020, published in Nature Reviews. Immunology
  • "Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response," 2021, published in Immunity
  • "Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up," 2020, published in Journal for ImmunoTherapy of Cancer
  • "Heterogeneity of type 2 innate lymphoid cells," 2022, published in Nature Reviews. Immunology
  • "Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases," 2021, published in Science Immunology

The scientist has frequently published in key venues such as:

  • Nature Reviews. Immunology
  • Allergy
  • Cancer Research
  • Immunity
  • Journal for ImmunoTherapy of Cancer

Frequent collaborators include Balthasar A. Heesters, Martijn Kedde, Korneliusz Golebski, Remko Schotte, and Julien Villaudy, each having co-authored multiple publications with Hergen Spits.

Best Publications

  • Innate lymphoid cells--a proposal for uniform nomenclature.

    Hergen Spits;David Artis;Marco Colonna;Andreas Diefenbach

  • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

    R de Waal Malefyt;J Haanen;H Spits;M G Roncarolo

  • Innate Lymphoid Cells: 10 Years On.

    Eric Vivier;David Artis;Marco Colonna;Andreas Diefenbach

  • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

    Eric A. Reits;James W Hodge;Carla A Herberts;Tom A M Groothuis

  • The biology of innate lymphoid cells

    David Artis;Hergen Spits

  • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T H -17, T H 1 and T H 2 cells

    Sara Trifari;Charles D Kaplan;Elise H Tran;Elise H Tran;Natasha K Crellin

  • Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.

    Jenny M Mjösberg;Sara Trifari;Sara Trifari;Natasha K Crellin;Natasha K Crellin;Charlotte P Peters

  • Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

    A. H. Schinkel;U. Mayer;E. Wagenaar;C. A. A. M. Mol

  • IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2

    J Pène;F Rousset;F Brière;I Chrétien

  • Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

    Jason S. McLellan;Man Chen;M. Gordon Joyce;Mallika Sastry

  • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

    Jochem H Bernink;Charlotte P Peters;Marius Munneke;Anje A te Velde

  • The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

    Hergen Spits;James P Di Santo;James P Di Santo

  • Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

    Hergen Spits;Tom Cupedo

  • Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC + CD127 + natural killer–like cells

    Tom Cupedo;Natasha K Crellin;Natalie Papazian;Elwin J Rombouts

  • The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

    Jenny Mjösberg;Jochem Bernink;Korneliusz Golebski;Julien J. Karrich

  • High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma

    Carsten Linnemann;Marit M van Buuren;Laura Bies;Els M E Verdegaal

  • Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

    Di-Hwei Hsu;R. De Waal Malefyt;D. F. Fiorentino;Minh-Ngoc Dang

  • Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

    X Paliard;R de Waal Malefijt;H Yssel;D Blanchard

  • Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

    Jochem H. Bernink;Lisette Krabbendam;Kristine Germar;Esther de Jong

  • IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

    Nicholas D. Huntington;Nicolas Legrand;Nuno L. Alves;Barbara Jaron

  • Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

    N J Stam;H Spits;H L Ploegh

Frequent Co-Authors

Bianca Blom
Bianca Blom University of Amsterdam
Jenny Mjösberg
Jenny Mjösberg Karolinska Institute
James P. Di Santo
James P. Di Santo Institut Pasteur
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Dominique Baeten
Dominique Baeten University of Amsterdam
Eric Vivier
Eric Vivier Aix-Marseille University
Mirjam H.M. Heemskerk
Mirjam H.M. Heemskerk Leiden University Medical Center
Nicholas D. Huntington
Nicholas D. Huntington Monash University
Hans Yssel
Hans Yssel Sorbonne University
John B. A. G. Haanen
John B. A. G. Haanen Antoni van Leeuwenhoek Hospital

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