World's Best Scientists 2026 revealed!

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Immunology

D-Index
118
Citations
53530
World Ranking
356
National Ranking
29

Medicine

D-Index
118
Citations
53531
World Ranking
4047
National Ranking
394

Research.com Recognitions

  • 2017 - Fellow of the Royal Society, United Kingdom

Overview

Andrew N. J. McKenzie is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily focuses on immunology and microbiology, contributing extensively to the fields of immunology and medicine with a notable emphasis on innate and adaptive immune responses.

The main topics of their work include:

  • IL-33, ST2, and ILC Pathways
  • Immune Cell Function and Interaction
  • Eosinophilic Esophagitis
  • Asthma and respiratory diseases
  • T-cell and B-cell Immunology
  • Cancer Immunotherapy and Biomarkers
  • SARS-CoV-2 and COVID-19 Research

The subfields of study covered in their publications include:

  • Immunology
  • Surgery
  • Infectious Diseases
  • Physiology
  • Oncology

Andrew N. J. McKenzie has published research in several frequent venues, which reflect the scope and focus of the scientific work:

  • Science Immunology
  • Nature Immunology
  • Immunity
  • The Journal of Immunology
  • Proceedings of the National Academy of Sciences

Selected recent papers highlight their contributions to the understanding of immune cell behavior and immune checkpoint mechanisms:

  • "Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma," 2021, Nature Immunology
  • "ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung," 2020, Nature Immunology
  • "ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation," 2020, Journal of Allergy and Clinical Immunology
  • "RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus," 2021, Nature Immunology
  • "SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation," 2021, Nature Metabolism

Frequent co-authors working alongside Andrew N. J. McKenzie include:

  • Helen E. Jolin
  • Paula A. Clark
  • Ana C. F. Ferreira
  • Noé Rodríguez-Rodríguez
  • Morgan W. D. Heycock

Among their recognitions is the election as a Fellow of the Royal Society, United Kingdom, awarded in 2017. This reflects a level of distinction within the scientific community in the United Kingdom.

Best Publications

  • Innate lymphoid cells--a proposal for uniform nomenclature.

    Hergen Spits;David Artis;Marco Colonna;Andreas Diefenbach

  • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

    Daniel R. Neill;See Heng Wong;Agustin Bellosi;Robin J. Flynn

  • Innate Lymphoid Cells: 10 Years On.

    Eric Vivier;David Artis;Marco Colonna;Andreas Diefenbach

  • IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

    Shoji Sanada;Daihiko Hakuno;Luke J. Higgins;Eric R. Schreiter

  • Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.

    Timotheus Y.F. Halim;Catherine A. Steer;Laura Mathä;Matthew J. Gold

  • A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

    Maryam Salimi;Jillian L. Barlow;Sean P. Saunders;Luzheng Xue

  • Innate lymphoid cells: A new paradigm in immunology

    Gérard Eberl;Marco Colonna;James P. Di Santo;Andrew N. J. McKenzie

  • Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

    Ya Jen Chang;Hye Young Kim;Lee A. Albacker;Nicole Baumgarth

  • Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

    Padraic G. Fallon;Sarah J. Ballantyne;Niamh E. Mangan;Jillian L. Barlow

  • Periostin: A novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals

    Go Takayama;Kazuhiko Arima;Taisuke Kanaji;Shuji Toda

  • MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

    Christopher J. Oliphant;You Yi Hwang;Jennifer A. Walker;Maryam Salimi

  • Innate lymphoid cells — how did we miss them?

    Unknown

  • ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.

    Elizabeth K Brint;Damo Xu;Haiying Liu;Aisling Dunne

  • T H 2 cell development and function

    Jennifer A Walker;Andrew N J McKenzie

  • Transcription factor RORα is critical for nuocyte development

    See Heng Wong;See Heng Wong;Jennifer A Walker;Helen E Jolin;Lesley F Drynan

  • Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

    Jillian L. Barlow;Agustin Bellosi;Clare S. Hardman;Lesley F. Drynan

  • An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

    Javier Corral;Isabelle Lavenir;Helen Impey;Alan J Warren

  • IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

    Kathleen R. Bartemes;Koji Iijima;Takao Kobayashi;Gail M. Kephart

  • IL-33 exacerbates antigen-induced arthritis by activating mast cells

    Damo Xu;Hui-Rong Jiang;Peter Kewin;Yubin Li

  • T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses

    Michael J. Townsend;Padraic G. Fallon;David J. Matthews;Helen E. Jolin

  • IL-33 Induces Antigen-Specific IL-5 + T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

    Mariola Kurowska-Stolarska;Pete Kewin;Grace Murphy;Remo C. Russo

  • Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent

    Padraic G. Fallon;Emma J. Richardson;Grahame J. McKenzie;Andrew N. J. McKenzie

Frequent Co-Authors

Padraic G. Fallon
Padraic G. Fallon Trinity College Dublin
Paul S. Foster
Paul S. Foster Woolcock Institute of Medical Research
Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge
Foo Y. Liew
Foo Y. Liew University of Glasgow
Graham S. Ogg
Graham S. Ogg University of Oxford
Damo Xu
Damo Xu University of Glasgow
Gabrielle T. Belz
Gabrielle T. Belz University of Queensland
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Klaus I. Matthaei
Klaus I. Matthaei Australian National University
Rick M. Maizels
Rick M. Maizels University of Glasgow

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