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Immunology

D-Index
85
Citations
34462
World Ranking
1300
National Ranking
51

Overview

Susumu Nakae is affiliated with Hiroshima University in Japan and has produced a substantial body of work primarily in the fields of Medicine and Immunology and Microbiology. Their research spans various subfields including Immunology, Surgery, Physiology, Dermatology, and Oncology.

The scientist's work focuses on key topics within immunology and related medical areas. These include:

  • IL-33, ST2, and ILC Pathways
  • Eosinophilic Esophagitis
  • Asthma and respiratory diseases
  • Immune Cell Function and Interaction
  • Dermatology and Skin Diseases
  • Ear Surgery and Otitis Media
  • Mast cells and histamine

Nakae has contributed to multiple publication venues, with frequent appearances in:

  • Practica Oto-Rhino-Laryngologica
  • Journal of Allergy and Clinical Immunology
  • Biochemical and Biophysical Research Communications
  • Allergy
  • Frontiers in Immunology

Some recent papers authored or co-authored by Nakae include:

  • "Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma," published in 2022 in Science Immunology
  • "Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s," published in 2023 in Allergy
  • "Roles of Mast Cells in Cutaneous Diseases," published in 2022 in Frontiers in Immunology
  • "A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury," published in 2023 in Nature Communications
  • "Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases," published in 2021 in Allergy

Throughout their career, Nakae has collaborated frequently with several researchers, indicating ongoing scientific partnerships. Notable frequent co-authors include Hirohisa Saito, Masashi Ikutani, Hideaki Morita, Katsuko Sudo, and Kenji Matsumoto.

Best Publications

  • IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

    Yutaka Komiyama;Susumu Nakae;Taizo Matsuki;Aya Nambu

  • Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

    Susumu Nakae;Aya Nambu;Katsuko Sudo;Yoichiro Iwakura

  • Functional Specialization of Interleukin-17 Family Members

    Yoichiro Iwakura;Harumichi Ishigame;Shinobu Saijo;Susumu Nakae

  • Mast cells in the development of adaptive immune responses

    Stephen J Galli;Susumu Nakae;Mindy Tsai

  • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses

    Susumu Nakae;Yutaka Komiyama;Aya Nambu;Katsuko Sudo

  • Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

    Harumichi Ishigame;Shigeru Kakuta;Takeshi Nagai;Motohiko Kadoki

  • Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

    Reiko Horai;Shinobu Saijo;Hidetoshi Tanioka;Susumu Nakae

  • A protective function for interleukin 17A in T cell–mediated intestinal inflammation

    William O'Connor;Masahito Kamanaka;Carmen J Booth;Terrence Town;Terrence Town

  • IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection

    Masayuki Umemura;Ayano Yahagi;Satoru Hamada;Mst Dilara Begum

  • IL-33 is a crucial amplifier of innate rather than acquired immunity

    Keisuke Oboki;Tatsukuni Ohno;Naoki Kajiwara;Ken Arae

  • IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

    Susumu Nakae;Shinobu Saijo;Reiko Horai;Katsuko Sudo

  • The roles of IL-17A in inflammatory immune responses and host defense against pathogens

    Yoichiro Iwakura;Susumu Nakae;Shinobu Saijo;Harumichi Ishigame

  • The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

    Ajithkumar Vasanthakumar;Kazuyo Moro;Annie Xin;Yang Liao

  • Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

    Michele A Grimbaldeston;Susumu Nakae;Janet Kalesnikoff;Mindy Tsai

  • Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung

    Yuko Okamoto Yoshida;Masayuki Umemura;Ayano Yahagi;Rebecca L. O’Brien

  • The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

    Weldy V. Bonilla;Anja Fröhlich;Anja Fröhlich;Karin Senn;Sandra Kallert

  • Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

    Susumu Nakae;Hajime Suto;Hajime Suto;Motoyasu Iikura;Maki Kakurai

  • IL-33 can promote survival, adhesion and cytokine production in human mast cells.

    Motoyasu Iikura;Hajime Suto;Hajime Suto;Naoki Kajiwara;Keisuke Oboki

  • IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver

    Satoru Hamada;Masayuki Umemura;Takeru Shiono;Kensho Tanaka

  • An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor

    Maho Suzukawa;Motoyasu Iikura;Rikiya Koketsu;Hiroyuki Nagase

  • Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.

    Susumu Nakae;Yoichiro Iwakura;Hajime Suto;Hajime Suto;Stephen J. Galli

Frequent Co-Authors

Hirohisa Saito
Hirohisa Saito Juntendo University
Katsuko Sudo
Katsuko Sudo Tokyo Medical University
Yoichiro Iwakura
Yoichiro Iwakura Tokyo University of Science
Kenji Matsumoto
Kenji Matsumoto Izumi Municipal Hospital
Ko Okumura
Ko Okumura Juntendo University
Akira Matsuda
Akira Matsuda Juntendo University
Masahide Asano
Masahide Asano Kyoto University
Hideoki Ogawa
Hideoki Ogawa Juntendo University
Shinobu Saijo
Shinobu Saijo Chiba University

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