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Immunology

D-Index
97
Citations
34779
World Ranking
824
National Ranking
464

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Xiaoxia Li is affiliated with the Cleveland Clinic Lerner College of Medicine in the United States. Their research spans multiple scientific disciplines, predominantly in medicine and biochemistry, genetics, and molecular biology. Their work encompasses a wide range of subfields including molecular biology, immunology, epidemiology, genetics, and pulmonary and respiratory medicine.

The scientist has contributed extensively to several research topics. Notable areas of focus include:

  • Nutritional Studies and Diet
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • Liver Disease Diagnosis and Treatment
  • Inflammasome and immune disorders
  • Nutrition and Health in Aging

A selection of recent significant publications includes the following papers:

  • "Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia", 2020, Aging and Disease
  • "Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src", 2021, Signal Transduction and Targeted Therapy
  • "Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis", 2020, Nature Communications
  • "Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer", 2020, Journal of Clinical Investigation
  • "GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis", 2022, Cell

Xiaoxia Li frequently collaborates with other researchers, with notable coauthors including:

  • Yi Zhao
  • Yuhong Zhang
  • Qingan Wang
  • Junjie Zhao
  • Katarzyna Bulek

Their work has been published in a range of scientific venues, including:

  • Research Square (Research Square)
  • Nature Communications
  • Scientific Reports
  • Infection and Drug Resistance
  • Aging and Disease

Their contributions to the scientific community have been recognized by an award of Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

    Jochen Schmitz;Alexander Owyang;Elizabeth Oldham;Yaoli Song

  • Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

    Horst Von Bernuth;Capucine Picard;Capucine Picard;Zhongbo Jin;Rungnapa Pankla;Rungnapa Pankla

  • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

    Wenchao Zhou;Susan Q. Ke;Zhi Huang;William Flavahan

  • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.

    David N Wald;Jinzhong Qin;Zhendong Zhao;Youcun Qian

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

    Jacob S. Lee;Cristina M. Tato;Barbara Joyce-Shaikh;Muhammet F. Gulen

  • The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease

    Youcun Qian;Caini Liu;Justin Hartupee;Cengiz Zubeyir Altuntas

  • IL-17 family: cytokines, receptors and signaling.

    Chunfang Gu;Ling Wu;Ling Wu;Xiaoxia Li

  • IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

    Holger Wesche;Xiong Gao;Xiaoxia Li;Carsten J. Kirschning

  • Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

    Joseph K. Rathkey;Junjie Zhao;Zhonghua Liu;Yinghua Chen

  • Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

    Zhengfan Jiang;Tak W. Mak;Ganes Sen;Xiaoxia Li

  • IL-17 receptor–based signaling and implications for disease

    Xiaoxia Li;Rami Bechara;Junjie Zhao;Mandy J. McGeachy

  • NFκB-dependent signaling pathways

    Xiaoxia Li;George R Stark

  • Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

    Cheng Lung Ku;Horst Von Bernuth;Horst Von Bernuth;Capucine Picard;Shen Ying Zhang

  • Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.

    Patricia R Taylor;Sanhita Roy;Sixto M Leal;Yan Sun

  • Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

    Zhengfan Jiang;Maryam Zamanian-Daryoush;Huiqing Nie;Aristobolo M. Silva

  • The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis

    Hui Xiao;Muhammet Fatih Gulen;Muhammet Fatih Gulen;Jinzhong Qin;Jinzhong Qin;Jianhong Yao

  • The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

    Bing He;Raul Santamaria;Weifeng Xu;Montserrat Cols

  • Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

    Zhengfan Jiang;Jun Ninomiya-Tsuji;Youcun Qian;Kunihiro Matsumoto

  • Regulation of STAT-dependent pathways by growth factors and cytokines.

    Douglas W. Leaman;Stewart Leung;Xiaoxia Li;George R. Stark

Frequent Co-Authors

Thomas A. Hamilton
Thomas A. Hamilton Cleveland Clinic
Paul L. Fox
Paul L. Fox Cleveland Clinic Lerner College of Medicine
Laurent Abel
Laurent Abel Université Paris Cité
George R. Stark
George R. Stark Cleveland Clinic
Bruce A. Vallance
Bruce A. Vallance University of British Columbia
Jun Qin
Jun Qin Cleveland Clinic Lerner College of Medicine
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Bing Su
Bing Su Shanghai Jiao Tong University
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center

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