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Biology and Biochemistry

D-Index
64
Citations
11781
World Ranking
9874
National Ranking
4325

Overview

Bysani Chandrasekar is affiliated with the University of Missouri in the United States. Their research primarily focuses on the intersection of medicine and biochemistry, genetics, and molecular biology, with a significant emphasis on cardiology and cardiovascular medicine. They have contributed extensively to understanding cardiovascular function, disease, and molecular signaling pathways involved in these conditions.

Their work includes studies on cardiovascular disease and adiposity, NF-κB signaling pathways, cardiovascular function and risk factors, liver disease diagnosis and treatment, protease and inhibitor mechanisms, peptidase inhibition and analysis, and adipokines, inflammation, and metabolic diseases.

Among their recent publications are:

  • The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion (2020, Cellular Signalling)
  • Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and death (2020, Cellular Signalling)
  • Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness (2021, Cardiovascular Diabetology)
  • Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling (2021, Cellular Signalling)
  • TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice (2020, Hypertension)

They frequently publish in venues such as The FASEB Journal, Physiology, Cellular Signalling, Cells, and Circulation. Their work has been cited in various contexts related to cardiovascular and molecular biology research.

They collaborate frequently with a core group of researchers, including Shawn B. Bender, Luis A. Martinez-Lemus, Yusuke Higashi, Tadashi Yoshida, and Jacob J. Russell, indicating an active involvement in collaborative research efforts spanning multiple aspects of cardiovascular and cellular signaling studies.

Best Publications

  • The Hamster as a Model of Human Visceral Leishmaniasis: Progressive Disease and Impaired Generation of Nitric Oxide in the Face of a Prominent Th1-Like Cytokine Response

    Peter C. Melby;Bysani Chandrasekar;Weigou Zhao;John E. Coe

  • beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling.

    Sumanth D. Prabhu;Bysani Chandrasekar;David R. Murray;Gregory L. Freeman

  • Chronic β-Adrenergic Stimulation Induces Myocardial Proinflammatory Cytokine Expression

    David R. Murray;Sumanth D. Prabhu;Bysani Chandrasekar

  • Ischemia-Reperfusion of Rat Myocardium Activates Nuclear Factor-κB and Induces Neutrophil Infiltration Via Lipopolysaccharide-Induced CXC Chemokine

    Bysani Chandrasekar;Jeffrey B. Smith;Gregory L. Freeman

  • IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation

    Dolores M. Cortez;Marc D. Feldman;Srinivas Mummidi;Anthony J. Valente

  • Interleukin-18-induced Human Coronary Artery Smooth Muscle Cell Migration Is Dependent on NF-κB- and AP-1-mediated Matrix Metalloproteinase-9 Expression and Is Inhibited by Atorvastatin

    Bysani Chandrasekar;Bysani Chandrasekar;Srinivas Mummidi;Srinivas Mummidi;Lenin Mahimainathan;Devang N. Patel

  • Decreased Proinflammatory Cytokines and Increased Antioxidant Enzyme Gene Expression by ω-3 Lipids in Murine Lupus Nephritis

    B. Chandrasekar;G. Fernandes

  • Interleukin-17 Stimulates C-reactive Protein Expression in Hepatocytes and Smooth Muscle Cells via p38 MAPK and ERK1/2-dependent NF-κB and C/EBPβ Activation

    Devang N. Patel;Carter A. King;Steven R. Bailey;Jeffrey W. Holt

  • Small Multifunctional Nanoclusters (Nanoroses) for Targeted Cellular Imaging and Therapy

    Li Leo Ma;Li Leo Ma;Marc David Feldman;Marc David Feldman;Jasmine M. Tam;Amit S. Paranjape

  • Malnutrition Alters the Innate Immune Response and Increases Early Visceralization following Leishmania donovani Infection

    Gregory M. Anstead;Bysani Chandrasekar;Weiguo Zhao;Jue Yang

  • CXCL16 Signals via Gi, Phosphatidylinositol 3-Kinase, Akt, IκB Kinase, and Nuclear Factor-κB and Induces Cell-Cell Adhesion and Aortic Smooth Muscle Cell Proliferation

    Bysani Chandrasekar;Sailaja Bysani;Srinivas Mummidi

  • Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.

    Bysani Chandrasekar;Srinivas Mummidi;Rao P Perla;Sailaja Bysani

  • Effects of n−3 and n−6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune‐prone NZB×NZW F1 mice

    Jaya T. Venkatraman;Bysani Chandrasekar;Jong Dai Kim;Gabriel Fernandes

  • Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp.

    Bruno L. Travi;Yaneth Osorio;Peter C. Melby;Peter C. Melby;Bysani Chandrasekar

  • Cloning of Syrian Hamster (Mesocricetus auratus) Cytokine cDNAs and Analysis of Cytokine mRNA Expression in Experimental Visceral Leishmaniasis

    Peter C. Melby;Victor V. Tryon;Bysani Chandrasekar;Gregory L. Freeman

  • Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression *

    Bysani Chandrasekar;William H. Boylston;Kaliyamurthi Venkatachalam;Nicholas J.G. Webster

  • Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes

    Bysani Chandrasekar;Srinivas M. Mummidi;Srinivas M. Mummidi;William C. Claycomb;Ruben Mestril

  • Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion.

    Bysani Chandrasekar;Donald H. Mitchell;James T. Colston;Gregory L. Freeman

  • Activation of Intrinsic and Extrinsic Proapoptotic Signaling Pathways in Interleukin-18-mediated Human Cardiac Endothelial Cell Death

    Bysani Chandrasekar;Kirankumar Vemula;Rama Mohan Surabhi;Min Li-Weber

  • Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury

    Kaliyamurthi Venkatachalam;Sumanth D. Prabhu;Sumanth D. Prabhu;Venkatapuram Seenu Reddy;William H. Boylston

Frequent Co-Authors

Anthony J. Valente
Anthony J. Valente The University of Texas Health Science Center at San Antonio
Ulrich Siebenlist
Ulrich Siebenlist National Institutes of Health
Peter C. Melby
Peter C. Melby The University of Texas Medical Branch at Galveston
Makoto Noda
Makoto Noda Kyoto University
Keith P. Johnston
Keith P. Johnston The University of Texas at Austin
Sanjay K. Srivastava
Sanjay K. Srivastava Texas Tech University Health Sciences Center
Robert A. Clark
Robert A. Clark The University of Texas Health Science Center at San Antonio
Goutam Ghosh Choudhury
Goutam Ghosh Choudhury The University of Texas Health Science Center at San Antonio
Thomas E. Milner
Thomas E. Milner University of California, Irvine
Konstantin V Sokolov
Konstantin V Sokolov The University of Texas MD Anderson Cancer Center

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