World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
7086
World Ranking
18979
National Ranking
664

Overview

Jean Gariépy is affiliated with the University of Toronto in Canada and has contributed extensively to several fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their research spans a variety of specialized subfields such as Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, Biomedical Engineering, and Oncology.

Their work focuses on topics related to immune cell function and interaction, cancer genomics and diagnostics, nanoplatforms for cancer theranostics, monoclonal and polyclonal antibodies research, immunotherapy and immune responses, gastric cancer management and outcomes, and immune cells in cancer.

Frequent collaborators in their publications include Amanda Sparkes, Yu-Heng Vivian, Esther Matus, Aaron Prodeus, and Nicholas W. Fischer.

They have published in multiple scientific journals, with recurrent publications appearing in Scientific Reports, Cancer Research, ACS Pharmacology & Translational Science, Signal Transduction and Targeted Therapy, and Cancers.

Notable recent papers include:

  • VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway (2023, Signal Transduction and Targeted Therapy)
  • TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy (2020, Cancers)
  • Coupling Chlorin e6 to the surface of Nanoscale Gas Vesicles strongly enhances their intracellular delivery and photodynamic killing of cancer cells (2020, Scientific Reports)
  • A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells (2020, JCI Insight)
  • Agonistic nanobodies and antibodies to human VISTA (2021, mAbs)

Best Publications

  • Synthetic peptides as nuclear localization signals.

    David S. Goldfarb;Jean Gariépy;Gary Schoolnik;Roger D. Kornberg

  • Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

    Elias Georges;Grace Bradley;Jean Gariepy;Victor Ling

  • Phototoxic aptamers selectively enter and kill epithelial cancer cells

    Cátia S. M. Ferreira;Melissa C. Cheung;Sotiris Missailidis;Stuart Bisland

  • Cell-surface proteoglycans as molecular portals for cationic peptide and polymer entry into cells.

    G.M.K. Poon;J. Gariépy

  • Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM.

    Yong Rao;Xiang-Fu Wu;Jean Gariepy;Urs Rutishauser

  • 111In-Labeled EGF Is Selectively Radiotoxic to Human Breast Cancer Cells Overexpressing EGFR

    Raymond M. Reilly;Reza Kiarash;Ross G. Cameron;Nicole Porlier

  • Calcium-induced protein folding. Structure-affinity relationships in synthetic analogs of the helix-loop-helix calcium binding unit.

    R E Reid;J Gariépy;A K Saund;R S Hodges

  • A comparison of EGF and MAb 528 labeled with 111In for imaging human breast cancer.

    Raymond M. Reilly;Reza Kiarash;Jasbir Sandhu;Ying Wai Lee

  • Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers

    Aaron Prodeus;Aws Abdul-Wahid;Nicholas W Fischer;Nicholas W Fischer;Eric H-B Huang

  • Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine

    T Kuno;Y Kamisaki;S A Waldman;J Gariepy

  • Loligomers: design of de novo peptide-based intracellular vehicles

    Katherine Sheldon;Deming Liu;James Ferguson;Jean Gariepy

  • Vectorial delivery of macromolecules into cells using peptide-based vehicles

    Jean Gariépy;Kim Kawamura

  • Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals

    Erik W. Orava;Nenad Cicmil;Jean Gariépy;Jean Gariépy

  • Probing the impact of valency on the routing of arginine-rich peptides into eukaryotic cells.

    Kim S Kawamura;Michael Sung;Eleonora Bolewska-Pedyczak;Jean Gariépy

  • A short DNA aptamer that recognizes TNFα and blocks its activity in vitro.

    Erik W Orava;Nick Jarvik;Yuen Lai Shek;Sachdev S Sidhu

  • Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.

    Pamela L. Beatty;Sowmya Narayanan;Jean Gariépy;Sarangarajan Ranganathan

  • Primary sequence analysis and folding behavior of EF hands in relation to the mechanism of action of troponin C and calmodulin

    Jean Gariépy;Robert S. Hodges

  • PET Imaging of Oncogene Overexpression Using 64Cu-Vasoactive Intestinal Peptide (VIP) Analog: Comparison with 99mTc-VIP Analog

    Mathew L Thakur;Mohan R Aruva;Jean Gariepy;Paul Acton

  • A Role for the Protease-sensitive Loop Region of Shiga-like Toxin 1 in the Retrotranslocation of Its A1 Domain from the Endoplasmic Reticulum Lumen

    Paul G. LaPointe;Xin Wei;Jean Gariépy

  • T-cell activation by peptide antigen: effect of peptide sequence and method of antigen presentation.

    Tania H. Watts;Jean Gariepy;Gary K. Schoolnik;Harden M. McConnell

Frequent Co-Authors

Gary K. Schoolnik
Gary K. Schoolnik Stanford University
Robert S. Hodges
Robert S. Hodges University of Colorado Denver
Olivera J. Finn
Olivera J. Finn University of Pittsburgh
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research
Brian D. Sykes
Brian D. Sykes University of Alberta
Reginald M. Gorczynski
Reginald M. Gorczynski University of Toronto
Jorge Filmus
Jorge Filmus Sunnybrook Health Science Centre
F. Stuart Foster
F. Stuart Foster University of Toronto
Daniele Merico
Daniele Merico University of Toronto
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre

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