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Reginald M. Gorczynski

Reginald M. Gorczynski

D-Index & Metrics

Immunology

D-Index
67
Citations
13168
World Ranking
2701
National Ranking
60

Overview

Reginald M. Gorczynski is affiliated with the University of Toronto in Canada and has contributed to the field of medicine, with a focus on immunology, infectious diseases, oncology, molecular biology, and surgery. Their research spans several key areas involving immune responses, cancer biology, and respiratory diseases.

Their recent scholarly output includes notable papers such as "IL-17 Signaling in the Tumor Microenvironment" (2020, Advances in experimental medicine and biology), "Nature of Acquired Immune Responses, Epitope Specificity and Resultant Protection from SARS-CoV-2" (2021, Journal of Personalized Medicine), along with contributions to collaborative works including "High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment" (2024, Frontiers in Immunology).

Reginald M. Gorczynski's publication record spans various peer-reviewed journals, prominently featuring venues such as Advances in genetics, Frontiers in Endocrinology, Frontiers in Immunology, Advances in experimental medicine and biology, and the Journal of Personalized Medicine.

Themself has co-authored multiple papers with a network of frequent collaborators including Edward J. Steele, Robyn A. Lindley, Robert Temple, Gensuke Tokoro, and N. C. Wickramasinghe.

Research interests and topics covered include:

  • SARS-CoV-2 and COVID-19 Research
  • Galectins and Cancer Biology
  • Cancer Immunotherapy and Biomarkers
  • Asthma and respiratory diseases
  • Immune cells in cancer
  • Psoriasis: Treatment and Pathogenesis
  • Lymphatic System and Diseases

Subfields within medicine that have been a focus in their work consist of:

  • Immunology
  • Infectious Diseases
  • Oncology
  • Molecular Biology
  • Surgery

In addition to journal articles, Gorczynski has published books through World Scientific, including the 2022 title "Understanding the Origin and Global Spread of COVID-19."

The combination of their work reflects a multidisciplinary approach to the medical sciences with emphasis on immune system mechanisms, cancer biology, infectious disease processes, and implications for treatment strategies.

Best Publications

  • Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

    Yen-Tung A. Teng;Hai Nguyen;Xuijuan Gao;Young-Yun Kong

  • Ribavirin Inhibits Viral-Induced Macrophage Production of TNF, IL-1, the Procoagulant fgl2 Prothrombinase and Preserves Th1 Cytokine Production But Inhibits Th2 Cytokine Response

    Qin Ning;D. Brown;J. Parodo;M. Cattral

  • Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival

    Wei-Ping Min;Reginald Gorczynski;Xu-Yan Huang;Michelle Kushida

  • The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis.

    Philip A. Marsden;Qin Ning;Laisum S. Fung;Xioping Luo

  • Conditioned immune response associated with allogeneic skin grafts in mice.

    R M Gorczynski;S Macrae;M Kennedy

  • Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice

    Nadine De Albuquerque;Ehtesham Baig;Xuezhong Ma;Jianhua Zhang

  • An Immunoadhesin Incorporating the Molecule OX-2 Is a Potent Immunosuppressant That Prolongs Allo- and Xenograft Survival

    Reginald M. Gorczynski;Mark S. Cattral;Zhigi Chen;Jiang Hu

  • Soluble Fibrinogen-Like Protein 2/Fibroleukin Exhibits Immunosuppressive Properties: Suppressing T Cell Proliferation and Inhibiting Maturation of Bone Marrow-Derived Dendritic Cells

    Camie W. Y. Chan;Lyndsey S. Kay;Rachel G. Khadaroo;Matthew W. C. Chan

  • Immunity to murine sarcoma virus-inducted tumors. II. Suppression of T cell-mediated immunity by cells from progressor animals.

    Reginald M. Gorczynski

  • CD200 Is a Ligand for All Members of the CD200R Family of Immunoregulatory Molecules

    Reginald Gorczynski;Zhiqi Chen;Yu Kai;Lydia Lee

  • Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R.

    Reginald M Gorczynski;Lydia Lee;Ivo Boudakov

  • CD200 Immunoadhesin Suppresses Collagen-Induced Arthritis in Mice

    Reginald M. Gorczynski;Zhiqi Chen;Kai Yu;Jiang Hu

  • CD200 and its receptors as targets for immunoregulation.

    Reginald M Gorczynski

  • Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2

    David A. Clark;Jin-Wen Ding;Gary Yu;Gary A. Levy

  • The same immunoregulatory molecules contribute to successful pregnancy and transplantation.

    Reginald M. Gorczynski;Sima Hadidi;Gary Yu;David A. Clark

  • The FGL2-FcγRIIB pathway: A novel mechanism leading to immunosuppression

    Hao Liu;Itay Shalev;Justin Manuel;Wei He

  • Increased expression of the novel molecule OX-2 is involved in prolongation of murine renal allograft survival.

    Reginald M. Gorczynski;Zhiqi Chen;Xin-Ming Fu;Hua Zeng

  • Prolongation of rat small bowel or renal allograft survival by pretransplant transfusion and/or by varying the route of allograft venous drainage.

    Reginald M. Gorczynski;Z. Chan;S. Chung;Z. Cohen

  • Evidence That an OX-2-Positive Cell Can Inhibit the Stimulation of Type 1 Cytokine Production by Bone Marrow-Derived B7-1 (and B7-2)-Positive Dendritic Cells

    Laura Gorczynski;Z. Chen;J. Hu;Y. Kai

  • Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population that inhibits alloreactivity in vitro and in vivo.

    Reginald M. Gorczynski;Kai Yu;David Clark;David Clark

Frequent Co-Authors

David A. Clark
David A. Clark McMaster University
Gary A. Levy
Gary A. Levy University of Toronto
Jean-Pierre Mach
Jean-Pierre Mach University of Lausanne
Otto Westphal
Otto Westphal Max Planck Society
Philip A. Marsden
Philip A. Marsden University of Toronto
Artur J. Ulmer
Artur J. Ulmer University of Freiburg
Klaus Brandenburg
Klaus Brandenburg Leibniz Institute for Neurobiology
Ulrich Zähringer
Ulrich Zähringer Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Ernst Th. Rietschel
Ernst Th. Rietschel Institute for Advanced Sustainability Studies
Jean Gariépy
Jean Gariépy University of Toronto

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