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Philip A. Marsden

Philip A. Marsden

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
21089
World Ranking
5041
National Ranking
182

Research.com Recognitions

  • 2014 - Fellow of the Royal Society of Canada Academy of Science

Overview

Philip A. Marsden is affiliated with the University of Toronto in Canada. Their research output spans fields related to biochemistry, genetics, and molecular biology, with a total of 25 publications in these areas. Additionally, Marsden has contributed to medical research, particularly with 13 publications connected to this field.

The subfields in which Marsden is active include molecular biology, cancer research, genetics, pulmonary and respiratory medicine, and neurology. The distribution of their research work shows a focus on both fundamental biological mechanisms and disease-specific studies.

The primary topics of Marsden's work encompass a range of molecular and regulatory mechanisms with an emphasis on cancer and RNA biology. These topics include:

  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Epigenetics and DNA methylation
  • Mesenchymal stem cell research
  • Kruppel-like factors research
  • Cancer, hypoxia, and metabolism

The scientist's recent contributions to academic literature include several papers published in diverse journals between 2020 and 2023. These works address cellular and molecular responses to injury, regulatory RNA molecules, and epigenetic phenomena. Notable papers are:

  • "Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury" (2021) in European Respiratory Journal
  • "Mesenchymal stromal/stem cells modulate response to experimental sepsis-induced lung injury via regulation of miR-27a-5p in recipient mice" (2020) in Thorax
  • "Translational remodeling by RNA-binding proteins and noncoding RNAs" (2021) in Wiley Interdisciplinary Reviews - RNA
  • "Epigenetic Heterogeneity and Mitotic Heritability Prime Endothelial Cell Gene Induction" (2020) in The Journal of Immunology
  • "Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-α induction and regulates hypoxic signaling" (2023) in Journal of Biological Chemistry

Marsden has frequently published in journals such as Scientific Reports, European Respiratory Journal, Thorax, Wiley Interdisciplinary Reviews - RNA, and The Journal of Immunology.

The scientist has collaborated extensively with a number of researchers. Frequent co-authors include:

  • Ranju Nair
  • Paul J. Turgeon
  • Kyung Ha Ku
  • Noeline Subramaniam
  • Aravin N. Sukumar

Among professional recognitions, Marsden was named a Fellow of the Royal Society of Canada in 2014, an acknowledgment from the Academy of Science.

Best Publications

  • Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

    Santiago Lamas;Philip A. Marsden;Gordon K. Li;Paul Tempst

  • Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.

    P. A. Marsden;H. H. Q. Heng;S. W. Scherer;R. J. Stewart

  • Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

    S Kourembanas;P A Marsden;L P McQuillan;D V Faller

  • Control of cardiac muscle cell function by an endogenous nitric oxide signaling system

    Jean-Luc Balligand;Ralph A. Kelly;Philip A. Marsden;Thomas W. Smith

  • Molecular cloning and characterization of human endothelial nitric oxide synthase

    Philip A. Marsden;Keith T. Schappert;Hai Sheine Chen;Michele Flowers

  • Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

    J N Wilcox;R R Subramanian;C L Sundell;W R Tracey

  • Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

    Lynda P. McQuillan;Gordon K. Leung;Philip A. Marsden;Sandra K. Kostyk

  • Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

    Philip A. Marsden;N. Raju Danthuluri;Barry M. Brenner;Barbara J. Ballermann

  • Structural organization of the human neuronal nitric oxide synthase gene (NOS1)

    A. V. Hall;H. Antoniou;Yang Wang;A. H. Cheung

  • Transcriptional regulation of the endothelin-1 gene by TNF-alpha.

    P. A. Marsden;B. M. Brenner

  • MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

    Fina Lovren;Yi Pan;Adrian Quan;Krishna K. Singh

  • VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

    Andrew J. Evans;Ryan C. Russell;Olga Roche;T. Nadine Burry

  • The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation.

    Yvonne Chan;Jason E. Fish;Cheryl D'Abreo;Steven Lin

  • Nitric oxide synthases: gene structure and regulation.

    Yang Wang;Philip A. Marsden

  • Epigenetic Regulation of Vascular Endothelial Gene Expression

    Charles C. Matouk;Philip A. Marsden

  • Characterization of the Human Endothelial Nitric-oxide Synthase Promoter

    Fotula Karantzoulis-Fegaras;Hariclia Antoniou;Sheue-Lim M. Lai;Girish Kulkarni

  • Angiogenesis in Glioblastoma

    Sunit Das;Philip A Marsden

  • The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

    Jason E. Fish;Charles C. Matouk;Alisa Rachlis;Steven Lin

  • Neuronal NOS: gene structure, mRNA diversity, and functional relevance.

    Yang Wang;Derek C. Newton;Philip A. Marsden

  • Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha.

    S. Lamas;T. Michel;B. M. Brenner;P. A. Marsden

Frequent Co-Authors

Barry M. Brenner
Barry M. Brenner Brigham and Women's Hospital
Reginald M. Gorczynski
Reginald M. Gorczynski University of Toronto
Myron I. Cybulsky
Myron I. Cybulsky University Health Network
Richard E. Gilbert
Richard E. Gilbert St. Michael's Hospital
Gary A. Levy
Gary A. Levy University of Toronto
David A. Clark
David A. Clark McMaster University
Thomas Michel
Thomas Michel Brigham and Women's Hospital
William C. Aird
William C. Aird Beth Israel Deaconess Medical Center
Susan E. Quaggin
Susan E. Quaggin Northwestern University
Michael Ohh
Michael Ohh University of Toronto

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