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Vladimir Tolmachev

Vladimir Tolmachev

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
16888
World Ranking
7027
National Ranking
97

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Vladimir Tolmachev is affiliated with Uppsala University in Sweden and has a research focus primarily within the field of Medicine, with a substantial emphasis on Radiology, Nuclear Medicine and Imaging. Their work spans several related subfields including Oncology, Pulmonary and Respiratory Medicine, Molecular Biology, and Epidemiology.

The main research topics covered in Tolmachev's publications include:

  • Radiopharmaceutical Chemistry and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • Peptidase Inhibition and Analysis
  • Prostate Cancer Treatment and Research
  • Medical Imaging Techniques and Applications
  • Glycosylation and Glycoproteins Research

Tolmachev has contributed numerous articles to multiple scientific journals, with the most frequent publication venues comprising:

  • Pharmaceutics
  • Nuclear Medicine and Biology
  • International Journal of Molecular Sciences
  • Cancers
  • EJNMMI Radiopharmacy and Chemistry

Recent papers by Tolmachev illustrate a focus on molecular imaging and targeted therapeutic probes, including:

  • "Affibody Molecules as Targeting Vectors for PET Imaging" (2020, Cancers)
  • "The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer" (2021, Seminars in Cancer Biology)

Other closely associated works often feature collaboration with frequent coauthors such as:

  • Anna Orlova
  • Anzhelika Vorobyeva
  • Maryam Oroujeni
  • Olga Bragina
  • Sergey M. Deyev

Tolmachev's studies often revolve around imaging techniques, protein-based probes for cancer diagnostics, and molecular targeting strategies. Examples include investigations of DARPin-based probes and scaffold protein-based visualization methods for HER2 expression in breast cancer, contributing to the field of nuclear medicine and radiopharmacy.

The scientific contributions of Tolmachev encompass a range of highly cited research papers that support developments in the intersection of molecular imaging and oncology, reinforcing the role of targeted radiopharmaceuticals in personalized medicine approaches.

Best Publications

  • Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications.

    John Löfblom;Joachim Feldwisch;Vladimir Tolmachev;Jörgen Carlsson

  • Tumor imaging using a picomolar affinity HER2 binding affibody molecule.

    Anna Orlova;Mikaela Magnusson;Tove L.J. Eriksson;Martin Nilsson

  • Selection and characterization of HER2/neu-binding affibody ligands.

    Maria Wikman;Ann-Charlott Steffen;Elin Gunneriusson;Vladimir Tolmachev

  • Molecular Imaging of HER2-Expressing Malignant Tumors in Breast Cancer Patients Using Synthetic 111In- or 68Ga-Labeled Affibody Molecules

    Richard P. Baum;Vikas Prasad;Dirk Müller;Christiane Schuchardt

  • Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule

    Vladimir Tolmachev;Anna Orlova;Rikard Pehrson;Joakim Galli

  • First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule

    Jens Sörensen;Dan Sandberg;Mattias Sandström;Anders Wennborg

  • Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [68Ga]ABY-025 Affibody PET/CT.

    Jens Sörensen;Irina Velikyan;Dan Sandberg;Anders Wennborg

  • Synthetic Affibody Molecules: A Novel Class of Affinity Ligands for Molecular Imaging of HER2-Expressing Malignant Tumors

    Anna Orlova;Vladimir Tolmachev;Rikard Pehrson;Malin Lindborg

  • Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain

    Jan Terje Andersen;Rikard Pehrson;Vladimir Tolmachev;Muluneh Bekele Daba

  • Pretargeted Imaging and Therapy

    Mohamed Altai;Rosemery Membreno;Brendon Cook;Vladimir Tolmachev

  • Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding Affibody molecule

    Mikaela Friedman;Anna Orlova;Eva Johansson;Tove L. J. Eriksson

  • Design of an optimized scaffold for affibody molecules.

    Joachim Feldwisch;Vladimir Tolmachev;Christofer Lendel;Nina Herne

  • Preparation and evaluation of (68)Ga-DOTA-hEGF for visualization of EGFR expression in malignant tumors.

    Irina Velikyan;Åsa Liljegren Sundberg;Örjan Lindhe;A Urban Höglund

  • Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy.

    Vladimir Tolmachev;Anna Orlova;Fredrik Y Nilsson;Joachim Feldwisch

  • On the Selection of a Tracer for PET Imaging of HER2-Expressing Tumors: Direct Comparison of a 124I-Labeled Affibody Molecule and Trastuzumab in a Murine Xenograft Model

    Anna Orlova;Helena Wållberg;Sharon Stone-Elander;Vladimir Tolmachev

  • Imaging of HER-2 overexpression in tumors for guiding therapy.

    Vladimir Tolmachev

  • In Vitro Characterization of a Bivalent Anti-HER-2 Affibody with Potential for Radionuclide-Based Diagnostics

    Ann-Charlott Steffen;Maria Wikman;Vladimir Tolmachev;Gregory P. Adams

  • Affibody molecules: new protein domains for molecular imaging and targeted tumor therapy.

    Fredrik Y Nilsson;Vladimir Tolmachev

  • VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

    Xiujuan Li;Narendra Padhan;Elisabet O. Sjöström;Francis P. Roche

  • Affibody Molecules for Epidermal Growth Factor Receptor Targeting In Vivo: Aspects of Dimerization and Labeling Chemistry

    Vladimir Tolmachev;Mikaela Friedman;Mattias Sandström;Tove L.J. Eriksson

Frequent Co-Authors

Anna Orlova
Anna Orlova Uppsala University
Stefan Ståhl
Stefan Ståhl Royal Institute of Technology
Jens Nørkær Sørensen
Jens Nørkær Sørensen Technical University of Denmark
Mats Larhed
Mats Larhed Uppsala University
Sophia Hober
Sophia Hober Royal Institute of Technology
Bengt Långström
Bengt Långström Uppsala University
Lena Claesson-Welsh
Lena Claesson-Welsh Uppsala University
Roger Schibli
Roger Schibli ETH Zurich
Jean-Pierre Tuchagues
Jean-Pierre Tuchagues Centre national de la recherche scientifique, CNRS

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