2026 Brian M. Zeglis: Chemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Chemistry	48	15299	13796	3876	3182	124	7739

Overview

Brian M. Zeglis is a researcher affiliated with Hunter College in the United States, with a focus primarily in the field of medicine. Their work spans several subfields including radiology, nuclear medicine and imaging, oncology, molecular biology, pulmonary and respiratory medicine, and organic chemistry.

The scientist's research encompasses diverse topics, reflecting a broad interest in biomedical applications and chemical processes. Their main topics of work include:

Radiopharmaceutical Chemistry and Applications
Monoclonal and Polyclonal Antibodies Research
Peptidase Inhibition and Analysis
HER2/EGFR in Cancer Research
Click Chemistry and Applications
Chemical Synthesis and Analysis
Cancer Research and Treatments

The publication record of Brian M. Zeglis consists of papers in notable scientific venues. Frequent publication venues include:

Nuclear Medicine and Biology
Journal of Nuclear Medicine
Molecular Pharmaceutics
Bioconjugate Chemistry
Clinical Cancer Research

Some recent papers authored or coauthored by the scientist are:

"Harnessing ⁶⁴Cu/ ⁶⁷Cu for a theranostic approach to pretargeted radioimmunotherapy" (2020), published in Proceedings of the National Academy of Sciences
"Targeted Brain Tumor Radiotherapy Using an Auger Emitter" (2020), published in Clinical Cancer Research
"Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy" (2020), published in Frontiers in Pharmacology
"Click chemistry: a transformative technology in nuclear medicine" (2023), published in Nature Protocols
"Click Chemistry and Radiochemistry: An Update" (2023), published in Bioconjugate Chemistry

The scientist has collaborated extensively with several coauthors, indicating a networked research approach. Frequent coauthors include:

Outi Keinänen
Jason S. Lewis
Samantha Delaney
Samantha M. Sarrett
Cindy Rodriguez

Brian M. Zeglis's work integrates advances in radiopharmaceutical chemistry, cancer research, and innovative chemical techniques such as click chemistry. This multidisciplinary approach supports ongoing development in diagnostic imaging and therapeutic strategies within medicine.

Best Publications

Metallo-intercalators and metallo-insertors

Brian M. Zeglis;Valerie C. Pierre;Jacqueline K. Barton

759
Citations
Abnormal C5-Bound N-Heterocyclic Carbenes: Extremely Strong Electron Donor Ligands and Their Iridium(I) and Iridium(III) Complexes

Anthony R. Chianese;Anes Kovacevic;Brian M. Zeglis;J. W. Faller

401
Citations
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry

Brian M. Zeglis;Kuntal K. Sevak;Thomas Reiner;Priya Mohindra

329
Citations
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.

Brian M. Zeglis;Vadim Divilov;Jason S. Lewis

258
Citations
Click Chemistry and Radiochemistry: The First 10 Years

Jan-Philip Meyer;Pierre Adumeau;Jason S. Lewis;Brian M. Zeglis;Brian M. Zeglis

248
Citations
A practical guide to the construction of radiometallated bioconjugates for positron emission tomography.

Brian M. Zeglis;Jason S. Lewis

220
Citations
Pretargeted Imaging and Therapy

Mohamed Altai;Rosemery Membreno;Brendon Cook;Vladimir Tolmachev

207
Citations
Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)

Melissa A. Deri;Shashikanth Ponnala;Shashikanth Ponnala;Brian M. Zeglis;Gabor Pohl

183
Citations
Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry

Brian M. Zeglis;Charles B. Davis;Robert Aggeler;Hee Chol Kang

170
Citations
Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

Brian M. Zeglis;Priya Mohindra;Gabriel I. Weissmann;Vadim Divilov

170
Citations
(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry.

Jan-Philip Meyer;Jacob L. Houghton;Paul Kozlowski;Dalya Abdel-Atti

165
Citations
The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

Dexing Zeng;Brian M. Zeglis;Jason S. Lewis;Carolyn J. Anderson

141
Citations
Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans

Pierre Adumeau;Sai Kiran Sharma;Colleen Brent;Brian M. Zeglis;Brian M. Zeglis

123
Citations
Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics

Brian M. Zeglis;Christian Brand;Dalya Abdel-Atti;Kathryn E. Carnazza

117
Citations
Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models

Sai Kiran Sharma;Andrew Chow;Sebastien Monette;Delphine Vivier

116
Citations
Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy.

Outi Keinänen;Outi Keinänen;Kimberly Fung;James M Brennan;Nicholas Zia

115
Citations
Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals

Brian M. Zeglis;Jacob L. Houghton;Michael J. Evans;Nerissa Viola-Villegas

105
Citations
Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry

Jacob L. Houghton;Rosemery Membreno;Dalya Abdel-Atti;Kristen M. Cunanan

103
Citations
Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging.

Brian M. Zeglis;Charles B. Davis;Dalya Abdel-Atti;Sean D. Carlin

103
Citations
The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies

Brian M. Zeglis;Jason S. Lewis

102
Citations
H4octapa-Trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy

Eric W. Price;Brian M. Zeglis;Jacqueline F. Cawthray;Jacqueline F. Cawthray;Caterina F. Ramogida;Caterina F. Ramogida

91
Citations
Targeting abasic sites and single base bulges in DNA with metalloinsertors.

Brian M. Zeglis;Jennifer A. Boland;Jacqueline K. Barton

90
Citations
An enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry

Charles Davis;Brian Zeglis;Jason Lewis;Brian Agnew

1
Citations

Frequent Co-Authors

Jason S. Lewis Memorial Sloan Kettering Cancer Center

Jacqueline K. Barton California Institute of Technology

Chris Orvig University of British Columbia

John T. Poirier New York University Langone Medical Center

Charles M. Rudin Memorial Sloan Kettering Cancer Center

John L. Humm Memorial Sloan Kettering Cancer Center

Ralph Weissleder Harvard University

Paul S. Donnelly University of Melbourne

Robert H. Crabtree Yale University

J. J. Dannenberg City University of New York

External Links

Personal website of Brian M. Zeglis

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Brian M. Zeglis

D-Index & Metrics

D-Index & Metrics

Chemistry

Overview

Best Publications

Metallo-intercalators and metallo-insertors

Abnormal C5-Bound N-Heterocyclic Carbenes: Extremely Strong Electron Donor Ligands and Their Iridium(I) and Iridium(III) Complexes

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry

Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.

Click Chemistry and Radiochemistry: The First 10 Years

A practical guide to the construction of radiometallated bioconjugates for positron emission tomography.

Pretargeted Imaging and Therapy

Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)

Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry

Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry.

The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans

Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics

Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models

Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy.

Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals

Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry

Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging.

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies

H4octapa-Trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy

Targeting abasic sites and single base bulges in DNA with metalloinsertors.

An enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry

Frequent Co-Authors

External Links

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