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Chemistry

D-Index
57
Citations
10395
World Ranking
11207
National Ranking
262

Overview

Paul S. Donnelly is affiliated with the University of Melbourne in Australia. Their research spans multiple fields, primarily focusing on medicine and materials science, with a particular emphasis on materials chemistry and radiology, nuclear medicine, and imaging.

The scientist has published extensively on various topics, including:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Radiopharmaceutical Chemistry and Applications
  • Alzheimer's Disease Research and Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • Trace Elements in Health
  • Peptidase Inhibition and Analysis

Frequent coauthors contributing alongside Donnelly include Jonathan M. White, Lachlan E. McInnes, Stacey E. Rudd, Peter Roselt, and Allan J. Canty.

Research outputs have been published in a range of scientific venues, with notable frequency in:

  • The Cambridge Structural Database
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Journal of Nuclear Medicine
  • Inorganic Chemistry

Representative recent publications showcase a focus on theranostics and radioimmunotherapy techniques:

  • Harnessing 64Cu/ 67Cu for a theranostic approach to pretargeted radioimmunotherapy, 2020, Proceedings of the National Academy of Sciences
  • Theranostic Nuclear Medicine with Gallium-68, Lutetium-177, Copper-64/67, Actinium-225, and Lead-212/203 Radionuclides, 2023, Chemical Reviews
  • Peptide Receptor Radionuclide Therapy with 67Cu-CuSarTATE Is Highly Efficacious Against a Somatostatin-Positive Neuroendocrine Tumor Model, 2020, Journal of Nuclear Medicine
  • Advances in the Surface Functionalization of Nanodiamonds for Biological Applications: A Review, 2021, ACS Applied Nano Materials
  • Preclinical Evaluation of a High-Affinity Sarcophagine-Containing PSMA Ligand for 64Cu/67Cu-Based Theranostics in Prostate Cancer, 2020, Molecular Pharmaceutics

Best Publications

  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

    Peter J. Crouch;Lin Wai Hung;Paul A. Adlard;Mikhalina Cortes

  • Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

    Brett M. Paterson;Paul S. Donnelly

  • Comparison of (64)Cu-complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability.

    Maggie S. Cooper;Michelle T. Ma;Kavitha Sunassee;Karen P. Shaw

  • An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives.

    Andrew R. Cowley;Jonathan R. Dilworth;Paul S. Donnelly;Elena Labisbal

  • The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

    Peter J Crouch;Maria S Savva;Lin W Hung;Lin W Hung;Paul S Donnelly

  • Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

    Paul S. Donnelly;Aphrodite Caragounis;Aphrodite Caragounis;Tai Du;Tai Du;Katrina M. Laughton;Katrina M. Laughton

  • Transfer of Copper between Bis(thiosemicarbazone) Ligands and Intracellular Copper-Binding Proteins. Insights into Mechanisms of Copper Uptake and Hypoxia Selectivity

    Zhiguang Xiao;Paul S Donnelly;Matthias Zimmermann;Anthony G Wedd

  • Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease

    David J Hayne;SinChun Lim;Paul S Donnelly

  • Copper and Alzheimer's disease.

    Paul S Donnelly;Zhiguang Xiao;Anthony G Wedd

  • Structural trends in copper(II) bis(thiosemicarbazone) radiopharmaceuticals

    Philip J. Blower;Thomas C. Castle;Andrew R. Cowley;Jonathan R. Dilworth

  • Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.

    Cynthia P.W. Soon;Paul S. Donnelly;Bradley J. Turner;Lin W. Hung

  • Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

    Michael A. Cater;Helen B. Pearson;Kamil Wolyniec;Paul Klaver

  • 'Click' cycloaddition catalysts: copper(I) and copper(II) tris(triazolylmethyl)amine complexes.

    Paul S Donnelly;Shannon D Zanatta;Steven C Zammit;Jonathan M White

  • Engineering poly(ethylene glycol) particles for improved biodistribution

    Jiwei Cui;Robert De Rose;Karen Maria Alt;Sheilajen Alcantara

  • Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals.

    Jason P Holland;Franklin I Aigbirhio;Helen M Betts;Paul D Bonnitcha

  • 64Cu-SARTATE PET Imaging of Patients with Neuroendocrine Tumors Demonstrates High Tumor Uptake and Retention, Potentially Allowing Prospective Dosimetry for Peptide Receptor Radionuclide Therapy.

    Rodney J. Hicks;Price Jackson;Grace Kong;Robert E. Ware

  • The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

    Paul S. Donnelly

  • Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.

    Paul A. Adlard;Paul A. Adlard;Laura Bica;Anthony R. White;Milawaty Nurjono

  • Functionalized thiosemicarbazone clusters of copper(I) and silver(I).

    Laura J. Ashfield;Andrew R. Cowley;Jonathan R. Dilworth;Paul S. Donnelly

  • Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

    Adam Southon;Kathryn Szostak;Karla M. Acevedo;Krista A. Dent

  • An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

    Paul S. Donnelly;Jeffrey R. Liddell;SinChun Lim;Brett M. Paterson

Frequent Co-Authors

Anthony R. White
Anthony R. White QIMR Berghofer Medical Research Institute
Kevin J. Barnham
Kevin J. Barnham Florey Institute of Neuroscience and Mental Health
Jonathan M. White
Jonathan M. White University of Melbourne
Rodney J. Hicks
Rodney J. Hicks Peter MacCallum Cancer Centre
Carleen Cullinane
Carleen Cullinane Peter MacCallum Cancer Centre
Richard A. J. O'Hair
Richard A. J. O'Hair University of Melbourne
Andrew R. Cowley
Andrew R. Cowley University of Oxford
Ashley I. Bush
Ashley I. Bush Florey Institute of Neuroscience and Mental Health
Roberto Cappai
Roberto Cappai University of Melbourne
Colin L. Masters
Colin L. Masters University of Melbourne

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