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Biology and Biochemistry

D-Index
61
Citations
10213
World Ranking
11596
National Ranking
319

Overview

Carleen Cullinane is affiliated with the Peter MacCallum Cancer Centre in Australia and has focused their research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work encompasses significant contributions to Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, Epidemiology, and Cancer Research.

The research topics addressed by Cullinane include:

  • Radiopharmaceutical Chemistry and Applications
  • Peptidase Inhibition and Analysis
  • Neuroendocrine Tumor Research Advances
  • Lung Cancer Research Studies
  • Cancer therapeutics and mechanisms
  • CAR-T cell therapy research
  • DNA Repair Mechanisms

Among their recent publications are the following papers:

  • "Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP," 2020, Scientific Reports
  • "Peptide Receptor Radionuclide Therapy with 67Cu-CuSarTATE Is Highly Efficacious Against a Somatostatin-Positive Neuroendocrine Tumor Model," 2020, Journal of Nuclear Medicine

Other notable papers in which they contributed as an author or co-author include:

  • "CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer," 2020, Nature Communications
  • "EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma," 2020, Journal of Investigative Dermatology
  • "The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer," 2020, British Journal of Cancer

Cullinane has collaborated frequently with other researchers, including:

  • Rodney J. Hicks
  • Jessica Van Zuylekom
  • Peter Roselt
  • Paul S. Donnelly
  • Grant A. McArthur

Their work has been published in several recurring venues, principally:

  • Journal of Medicinal Chemistry
  • Cancer Research
  • Nature Communications
  • Journal of Nuclear Medicine
  • Chemical Science

Best Publications

  • Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.

    Megan J Bywater;Gretchen Poortinga;Gretchen Poortinga;Elaine Sanij;Elaine Sanij;Nadine Hein

  • An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

    Marian L. Burr;Marian L. Burr;Marian L. Burr;Christina E. Sparbier;Christina E. Sparbier;Kah Lok Chan;Kah Lok Chan;Yih-Chih Chan

  • Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study

    Vanya D. Uzunova;Carleen Cullinane;Klaudia Brix;Werner M. Nau

  • UV-associated mutations underlie the etiology of MCV-negative Merkel cell carcinomas

    Stephen Q. Wong;Kelly Waldeck;Ismael A. Vergara;Jan Schröder;Jan Schröder;Jan Schröder

  • Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

    David Shi Hao Liu;Cuong Phu Duong;Sue Haupt;Karen G Montgomery

  • Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

    Tiffany J. Parmenter;Margarete Kleinschmidt;Kathryn M. Kinross;Simon T. Bond

  • Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.

    Richard J. Young;Kelly Waldeck;Claire Martin;Jung H. Foo

  • An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.

    Kathryn M Kinross;Karen G Montgomery;Margarete Kleinschmidt;Paul Waring

  • CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.

    Elaine Sanij;Elaine Sanij;Katherine M. Hannan;Katherine M. Hannan;Jiachen Xuan;Jiachen Xuan;Shunfei Yan;Shunfei Yan

  • Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug.

    Timothy W. Failes;Carleen Cullinane;Connie I. Diakos;Natsuho Yamamoto

  • EGFR blockade with ZD1839 (“Iressa”) potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma

    Benjamin Solomon;Jim Hagekyriakou;Melanie K Trivett;Steven A Stacker

  • Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

    Nial J. Wheate;Anthony I. Day;Rodney J. Blanch;Alan P. Arnold

  • Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.

    Gerald Reischl;Donna S Dorow;Carleen Cullinane;Andrew Katsifis

  • PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

    Brett M. Paterson;Peter Roselt;Delphine Denoyer;Carleen Cullinane;Carleen Cullinane

  • Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.

    George H. Au-Yeung;George H. Au-Yeung;Franziska Lang;Walid J Azar;Chris Mitchell

  • An In vivo Tumor Model Exploiting Metabolic Response as a Biomarker for Targeted Drug Development

    Carleen Cullinane;Donna S. Dorow;Maya Kansara;Nelly Conus

  • Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

    Jennifer R Devlin;Katherine M Hannan;Katherine M Hannan;Nadine Hein;Nadine Hein;Carleen M Cullinane;Carleen M Cullinane

  • LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

    Prue A Cowin;Joshy George;Joshy George;Sian Fereday;Elizabeth Loehrer

  • Resistance to CDK2 Inhibitors Is Associated with Selection of Polyploid Cells in CCNE1-Amplified Ovarian Cancer

    Dariush Etemadmoghadam;George Au-Yeung;Meaghan Wall;Chris Mitchell

  • Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian Cancer

    Dariush Etemadmoghadam;Joshy George;Joshy George;Prue A. Cowin;Carleen Cullinane

Frequent Co-Authors

Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Rodney J. Hicks
Rodney J. Hicks Peter MacCallum Cancer Centre
Richard B. Pearson
Richard B. Pearson Peter MacCallum Cancer Centre
Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre
Ross D. Hannan
Ross D. Hannan Australian National University
Paul S. Donnelly
Paul S. Donnelly University of Melbourne
David D.L. Bowtell
David D.L. Bowtell Peter MacCallum Cancer Centre
Peter Hersey
Peter Hersey University of Sydney
Wayne A. Phillips
Wayne A. Phillips Peter MacCallum Cancer Centre
Anthony T. Papenfuss
Anthony T. Papenfuss Walter and Eliza Hall Institute of Medical Research

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