2022 - Research.com Chemistry in Czech Republic Leader Award
The scientist’s investigation covers issues in DNA, Stereochemistry, Cisplatin, Platinum and Guanine. The DNA study combines topics in areas such as Bifunctional, Adduct and Circular dichroism. His Stereochemistry research includes elements of Gel electrophoresis, Base pair, Ligand and Ruthenium.
Viktor Brabec has included themes like Mechanism of action, Platinum Compound, DNA damage and Cytotoxicity in his Cisplatin study. His Platinum research is multidisciplinary, relying on both Dna interaction, Combinatorial chemistry, Pharmacology, Antitumor activity and Chloride. Viktor Brabec has researched Guanine in several fields, including Ethidium bromide, Ethylenediamine and Molecule, Hydrogen bond.
DNA, Stereochemistry, Cisplatin, Platinum and Biochemistry are his primary areas of study. His DNA study also includes fields such as
Viktor Brabec interconnects Cancer cell, Cell culture, DNA repair and Cytotoxicity in the investigation of issues within Cisplatin. His biological study spans a wide range of topics, including Prodrug, Cancer research and Mechanism of action. The concepts of his Platinum study are interwoven with issues in Combinatorial chemistry, Molecule, Oxaliplatin and Polarography.
Viktor Brabec spends much of his time researching DNA, Cisplatin, Stereochemistry, Cancer cell and Combinatorial chemistry. His DNA research includes themes of Biophysics, Platinum, Intercalation and Amine gas treating. His studies deal with areas such as Cell culture, Moiety, Ligand and Cytotoxicity as well as Cisplatin.
His Stereochemistry research is multidisciplinary, incorporating elements of IC50 and Structural motif. His Cancer cell research incorporates elements of Prodrug, Cancer research, DNA damage and Mechanism of action. His work deals with themes such as Selectivity, Biological activity, Antimicrobial and Coordination complex, which intersect with Combinatorial chemistry.
Viktor Brabec mainly focuses on DNA, Cisplatin, Combinatorial chemistry, Cytotoxicity and Cancer cell. Viktor Brabec is involved in the study of DNA that focuses on Topoisomerase in particular. His Combinatorial chemistry research also works with subjects such as
His research integrates issues of Cytotoxic T cell, Cell culture and Stereochemistry in his study of Cytotoxicity. His Stereochemistry research incorporates themes from IC50 and Ligand. His Cancer cell study combines topics from a wide range of disciplines, such as Prodrug and Cancer research.
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DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity.
Viktor Brabec;Olga Nováková.
Drug Resistance Updates (2006)
Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.
Viktor Brabec;Jana Kasparkova.
Drug Resistance Updates (2005)
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.
Olga Novakova;Haimei Chen;Oldrich Vrana;Alison Rodger.
DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.
Viktor Brabec;Marc Leng.
Proceedings of the National Academy of Sciences of the United States of America (1993)
A potent cytotoxic photoactivated platinum complex
Fiona S. Mackay;Julie A. Woods;Julie A. Woods;Pavla Heringová;Jana Kašpárková.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Correlation between cytotoxicity and DNA binding of polypyridyl ruthenium complexes.
O Nováková;J Kaspárková;O Vrána;P M van Vliet.
Organometallic Half-Sandwich Iridium Anticancer Complexes
Zhe Liu;Abraha Habtemariam;Ana M. Pizarro;Sally A. Fletcher.
Journal of Medicinal Chemistry (2011)
DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair.
Progress in Nucleic Acid Research and Molecular Biology (2002)
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.
Viktor Brabec;Jana Kašpárková;Oldřich Vrána;Olga Nováková.
Double‐check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair
Miriam Missura;Tonko Buterin;Robert Hindges;Ulrich Hübscher.
The EMBO Journal (2001)
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