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Chemistry

D-Index
80
Citations
20088
World Ranking
3478
National Ranking
17

Overview

Viktor Brabec is affiliated with the Czech Academy of Sciences in the Czech Republic. Their research contributions span multiple fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, Chemistry, and Medicine. Within these disciplines, the scientist has concentrated on subfields such as Molecular Biology, Organic Chemistry, Oncology, Materials Chemistry, and Inorganic Chemistry.

The main topics addressed in their work include:

  • Metal complexes synthesis and properties
  • Advanced biosensing and bioanalysis techniques
  • Click Chemistry and Applications
  • DNA and Nucleic Acid Chemistry
  • Ferrocene Chemistry and Applications
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Brabec's recent scientific papers include:

  • Induction of immunogenic cell death in cancer cells by a photoactivated platinum(iv) prodrug, 2020, Inorganic Chemistry Frontiers
  • A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death, 2021, Inorganic Chemistry Frontiers
  • Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis, 2022, Journal of Medicinal Chemistry
  • Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?, 2021, Journal of Medicinal Chemistry
  • A Multi-action PtIV Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells, 2020, Angewandte Chemie International Edition

Frequent co-authors collaborating with Viktor Brabec are:

  • Jana Kašpárková
  • Hana Kostrhunová
  • Vojtěch Novohradský
  • Lenka Marková
  • Jaroslav Malina

The scientist has published extensively in several academic journals and databases, with notable frequent publication venues including:

  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry
  • Inorganic Chemistry Frontiers
  • Chemico-Biological Interactions
  • Chemistry - A European Journal

Best Publications

  • DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity.

    Viktor Brabec;Olga Nováková

  • Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.

    Viktor Brabec;Jana Kasparkova

  • DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.

    Olga Novakova;Haimei Chen;Oldrich Vrana;Alison Rodger

  • Organometallic Half-Sandwich Iridium Anticancer Complexes

    Zhe Liu;Abraha Habtemariam;Ana M. Pizarro;Sally A. Fletcher

  • A potent cytotoxic photoactivated platinum complex

    Fiona S. Mackay;Julie A. Woods;Julie A. Woods;Pavla Heringová;Jana Kašpárková

  • Correlation between cytotoxicity and DNA binding of polypyridyl ruthenium complexes.

    O Nováková;J Kaspárková;O Vrána;P M van Vliet

  • DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

    Viktor Brabec;Marc Leng

  • DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair.

    Viktor Brabec

  • DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.

    Viktor Brabec;Jana Kašpárková;Oldřich Vrána;Olga Nováková

  • Double‐check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair

    Miriam Missura;Tonko Buterin;Robert Hindges;Ulrich Hübscher

  • Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

    Suzanne E. Howson;Albert Bolhuis;Viktor Brabec;Guy J. Clarkson

  • Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

    Neil P. Johnson;Jean-Luc Butour;Giuseppe Villani;Franz L. Wimmer

  • Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin

    Vojtech Novohradsky;Anna Rovira;Cormac Hally;Alex Galindo

  • Molecular aspects of resistance to antitumor platinum drugs.

    Viktor Brabec;Jana Kasparkova

  • DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464 CONFORMATION, RECOGNITION BY HIGH MOBILITY GROUP DOMAIN PROTEINS, AND NUCLEOTIDE EXCISION REPAIR

    Jana Kasparkova;Jana Zehnulova;Nicholas Farrell;Viktor Brabec

  • Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin

    Kateřina Chválová;Viktor Brabec;Jana Kašpárková

  • Pt( iv ) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

    Raji Raveendran;Jeremy Phillip Braude;Ezequiel Wexselblatt;Vojtech Novohradsky

  • Interaction of nucleic acids with electrically charged surfaces: II. Conformational changes in double-helical polynucleotides

    Viktor Brabec;Emil Paleček

  • Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

    Viktor Brabec;Jana Kasparkova

  • Electrochemical behaviour of proteins at graphite electrodes. II. Electrooxidation of amino acids.

    Viktor Brabec;Vojtěch Mornstein

  • Biophysical studies of the modification of DNA by antitumour platinum coordination complexes.

    Viktor Brabec;Vladimir Kleinwächter;Jean-Luc Butour;Neil P. Johnson

Frequent Co-Authors

Jana Kasparkova
Jana Kasparkova Czech Academy of Sciences
Nicholas Farrell
Nicholas Farrell Virginia Commonwealth University
Peter J. Sadler
Peter J. Sadler University of Warwick
Giovanni Natile
Giovanni Natile University of Bari Aldo Moro
Dan Gibson
Dan Gibson Hebrew University of Jerusalem
Abraha Habtemariam
Abraha Habtemariam University of Warwick
Peter Scott
Peter Scott University of Warwick
Guy J. Clarkson
Guy J. Clarkson University of Warwick
José Ruiz
José Ruiz University of Murcia
Glenn Dryhurst
Glenn Dryhurst University of Oklahoma

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