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David Stokoe

David Stokoe

D-Index & Metrics

Molecular Biology

D-Index
70
Citations
30708
World Ranking
1395
National Ranking
708

Overview

David Stokoe is a researcher affiliated with Genentech in the United States. Their work primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with a substantial contribution in Molecular Biology. Other areas of study include Oncology, Immunology, Epidemiology, and Physiology.

Their research topics cover a variety of specialized subjects, including:

  • RNA modifications and cancer
  • Ubiquitin and proteasome pathways
  • Epigenetics and DNA Methylation
  • Cervical Cancer and HPV Research
  • Cancer-related Molecular Pathways
  • Immune Cell Function and Interaction
  • Peptidase Inhibition and Analysis

David Stokoe has published in several scientific journals, with frequent publications appearing in the following venues:

  • Nature Communications
  • Cancer Research
  • Immunity
  • Cancer Research Communications
  • Communications Chemistry

Their recent papers highlight ongoing research in molecular mechanisms related to cancer and immune response. Key publications include:

  • "Structure of the p53 degradation complex from HPV16," 2024, Nature Communications
  • "Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint," 2024, Immunity
  • "Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I," 2024, Cancer Research Communications
  • "Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex," 2024, Communications Chemistry
  • "BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system," 2025, Nature Communications

Among their frequent coauthors are:

  • Ari Firestone
  • Michael E. Kort
  • Amirhossein Mafi
  • Matthew Bratkowski
  • Dan Eaton

Best Publications

  • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

    Georgia Hatzivassiliou;Kyung Song;Ivana Yen;Barbara J. Brandhuber

  • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

    Ingo K. Mellinghoff;Maria Y. Wang;Igor Vivanco;Daphne A. Haas-Kogan

  • Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

    David Stokoe;Leonard R. Stephens;Terry Copeland;Piers R. J. Gaffney

  • Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

    Len Stephens;Karen Anderson;David Stokoe;Hediye Erdjument-Bromage

  • A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

    Zachary A Knight;Beatriz Gonzalez;Morri E Feldman;Eli R Zunder

  • Activation of Raf as a result of recruitment to the plasma membrane

    David Stokoe;Susan G. Macdonald;Karen Cadwallader;Marc Symons

  • Loss of PTEN facilitates HIF-1-mediated gene expression

    Wayne Zundel;Cornelia Schindler;Daphne Haas-Kogan;Albert Koong

  • Diverse somatic mutation patterns and pathway alterations in human cancers

    Zhengyan Kan;Bijay S. Jaiswal;Jeremy Stinson;Vasantharajan Janakiraman

  • Induction of NF-κB by the Akt/PKB kinase

    Lawrence P. Kane;Virginia Smith Shapiro;David Stokoe;Arthur Weiss

  • A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

    Qi-Wen Fan;Zachary A. Knight;David D. Goldenberg;Wei Yu

  • Akt activation by growth factors is a multiple-step process: the role of the PH domain.

    Alfonso Bellacosa;Tung O Chan;Naheed N Ahmed;Ketaki Datta

  • PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

    Phillip T. Hawkins;Alicia Eguinoa;Rong-Guo Qiu;David Stokoe

  • Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

    Till Maurer;Lindsay S. Garrenton;Angela Oh;Keith Pitts

  • Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

    David Stokoe;Katrin Engel;David G. Campbell;Philip Cohen

  • A comprehensive transcriptional portrait of human cancer cell lines

    Christiaan Klijn;Steffen Durinck;Eric W Stawiski;Peter M Haverty

  • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

    Daphne Haas-Kogan;Noga Shalev;Michelle Wong;Gordon Mills

  • MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

    D. Stokoe;D.G. Campbell;S. Nakielny;H. Hidaka

  • Epidermal Growth Factor Receptor, Protein Kinase B/Akt, and Glioma Response to Erlotinib

    Daphne A. Haas-Kogan;Michael D. Prados;Tarik Tihan;David A. Eberhard

  • High Frequency of Coexistent Mutations of PIK3CA and PTEN Genes in Endometrial Carcinoma

    Katsutoshi Oda;David Stokoe;Yuji Taketani;Frank McCormick

  • Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

    Mignon L. Loh;Shashaank Vattikuti;Suzanne Schubbert;Melissa G. Reynolds

Frequent Co-Authors

Frank McCormick
Frank McCormick University of California, San Francisco
Kevan M. Shokat
Kevan M. Shokat University of California, San Francisco
Mitchel S. Berger
Mitchel S. Berger University of California, San Francisco
Kathleen R. Lamborn
Kathleen R. Lamborn University of California, San Francisco
Alexander Gottschalk
Alexander Gottschalk Michigan State University
Zora Modrusan
Zora Modrusan Genentech
Michael D. Prados
Michael D. Prados University of California, San Francisco
Tarik Tihan
Tarik Tihan University of California, San Francisco
Philip Cohen
Philip Cohen University of Dundee

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