World's Best Scientists 2026 revealed!
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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
146
Citations
77333
World Ranking
97
National Ranking
61

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2011 - Fellow of the American Academy of Arts and Sciences
  • 2010 - Member of the National Academy of Medicine (NAM)
  • 2009 - Member of the National Academy of Sciences

Overview

Kevan M. Shokat is affiliated with the University of California, San Francisco in the United States. Their research contributions span various topics within biochemistry, genetics, molecular biology, medicine, immunology, and microbiology.

Their recent publications include:

  • Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket (2024, Cell)
  • IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle (2024, Proceedings of the National Academy of Sciences)
  • Abstract PL02-01: Overcoming the undruggable nature of the most common human oncogene, K-Ras (2025, Cancer Research)

Frequent co-authors collaborating with Shokat include Johannes Morstein, Vickie Bowcut, Micah C. Fernando, Yue Yang, and Lawrence Zhu.

Shokat's work has been published in venues such as Cell, Proceedings of the National Academy of Sciences, and Cancer Research.

The scientist's main fields of study are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Immunology and Microbiology

Within these fields, subfields of focus include:

  • Molecular Biology
  • Immunology
  • Cell Biology
  • Physiology
  • Pulmonary and Respiratory Medicine

Topics addressed in Shokat's research cover:

  • Protein Kinase Regulation and GTPase Signaling
  • Cellular transport and secretion
  • Cell death mechanisms and regulation
  • Asthma and respiratory diseases
  • IL-33, ST2, and ILC Pathways
  • Immune Response and Inflammation
  • PI3K/AKT/mTOR signaling in cancer

The scientist has received several recognitions including:

  • Fellow of the American Academy of Arts and Sciences in 2011
  • Member of the National Academy of Medicine in 2010
  • Member of the National Academy of Sciences in 2009

Best Publications

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

    David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

  • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

    Poulikos I. Poulikakos;Chao Zhang;Gideon Bollag;Kevan M. Shokat

  • IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

    Jonathan H. Lin;Han Li;Douglas Yasumura;Hannah R. Cohen

  • The translational landscape of mTOR signalling steers cancer initiation and metastasis

    Andrew C. Hsieh;Yi Liu;Merritt P. Edlind;Nicholas T. Ingolia

  • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.

    Natalia V. Sergina;Megan Rausch;Donghui Wang;Jimmy Blair

  • A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

    Zachary A Knight;Beatriz Gonzalez;Morri E Feldman;Eli R Zunder

  • The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule

    Stephan Schauder;Kevan Shokat;Michael G. Surette;Bonnie L. Bassler

  • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

    Morris E Feldman;Beth Apsel;Aino Uotila;Robbie Loewith

  • A chemical switch for inhibitor-sensitive alleles of any protein kinase

    Anthony C. Bishop;Jeffrey A. Ubersax;Dejah T. Petsch;Dina P. Matheos

  • Targets of the cyclin-dependent kinase Cdk1

    Jeffrey A. Ubersax;Erika L. Woodbury;Erika L. Woodbury;Phuong N. Quang;Phuong N. Quang;Maria Paraz;Maria Paraz

  • The Global Phosphorylation Landscape of SARS-CoV-2 Infection.

    Mehdi Bouhaddou;Danish Memon;Bjoern Meyer;Kris M. White

  • Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure

    A. G. Nackley;S. A. Shabalina;I. E. Tchivileva;K. Satterfield

  • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Stephan Sauer;Ludovica Bruno;Arnulf Hertweck;David Finlay

  • The unfolded protein response signals through high-order assembly of Ire1.

    Alexei V. Korennykh;Pascal F. Egea;Andrei A. Korostelev;Janet Finer-Moore

  • Targeting the cancer kinome through polypharmacology.

    Zachary A. Knight;Henry Lin;Kevan M. Shokat

  • Features of Selective Kinase Inhibitors

    Zachary A. Knight;Kevan M. Shokat;Kevan M. Shokat

  • A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

    Qi-Wen Fan;Zachary A. Knight;David D. Goldenberg;Wei Yu

  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

    David E. Gordon;Joseph Hiatt;Mehdi Bouhaddou;Veronica V. Rezelj

  • Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

    Michael S. Cohen;Chao Zhang;Kevan M. Shokat;Jack Taunton

  • Site-specific installation of methyl-lysine analogues into recombinant histones

    Kevan Shokat;Matthew D. Simon

Frequent Co-Authors

Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco
Kavita Shah
Kavita Shah Purdue University West Lafayette
Robert P. Fisher
Robert P. Fisher Icahn School of Medicine at Mount Sinai
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Frank McCormick
Frank McCormick University of California, San Francisco
Andrei Goga
Andrei Goga University of California, San Francisco
Davide Ruggero
Davide Ruggero University of California, San Francisco
Arthur Weiss
Arthur Weiss University of California, San Francisco
Peter Walter
Peter Walter University of California, San Francisco

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