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Biology and Biochemistry
UK
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
42690
World Ranking
1969
National Ranking
125

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Bart Vanhaesebroeck is affiliated with University College London in the United Kingdom, focusing on research in Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their subfields of study include Molecular Biology, Oncology, Immunology, Genetics, and Ophthalmology.

Their main research topics encompass:

  • PI3K/AKT/mTOR signaling in cancer
  • Immune Cell Function and Interaction
  • CRISPR and Genetic Engineering
  • Cancer Genomics and Diagnostics
  • Cellular transport and secretion
  • Ocular Oncology and Treatments
  • Retinal Development and Disorders

The scientist has contributed extensively to several publication venues, with a significant number of papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Reviews Drug Discovery
  • Nature
  • Science Signaling
  • Nature Communications

Key recent publications include:

  • PI3K inhibitors are finally coming of age, 2021, Nature Reviews Drug Discovery
  • A small-molecule PI3Kα activator for cardioprotection and neuroregeneration, 2023, Nature
  • Cracking the context-specific PI3K signaling code, 2020, Science Signaling
  • Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs, 2022, Nature
  • Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy, 2021, Nature Communications

Bart Vanhaesebroeck collaborates frequently with other researchers, including Ralitsa R. Madsen, Klaus Okkenhaug, Benoît Bilanges, Wayne Pearce, and Maria A. Whitehead.

Recognition for their contributions includes memberships and fellowships such as:

  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom

Best Publications

  • PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS

    Pablo Rodriguez-Viciana;Patricia H. Warne;Ritu Dhand;Bart Vanhaesebroeck

  • The PI3K-PDK1 connection: more than just a road to PKB.

    Bart Vanhaesebroeck;Dario R. Alessi

  • Synthesis and Function of 3-Phosphorylated Inositol Lipids

    Bart Vanhaesebroeck;Sally J. Leevers;Khatereh Ahmadi;John Timms

  • The emerging mechanisms of isoform-specific PI3K signalling

    Bart Vanhaesebroeck;Julie Guillermet-Guibert;Mariona Graupera;Benoit Bilanges

  • Phosphoinositide 3-kinases: a conserved family of signal transducers.

    Bart Vanhaesebroeck;Sally J. Leevers;George Panayotou;Michael D. Waterfield

  • Signaling by distinct classes of phosphoinositide 3-kinases

    B. Vanhaesebroeck;M.D. Waterfield;M.D. Waterfield

  • Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

    Klaus Okkenhaug;Antonio Bilancio;Géraldine Farjot;Helen Priddle

  • Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

    K Schulzeosthoff;Ac Bakker;Bart Vanhaesebroeck;Rudi Beyaert

  • PI3K signalling: the path to discovery and understanding

    Bart Vanhaesebroeck;Len Stephens;Phillip Hawkins

  • PI3K in lymphocyte development, differentiation and activation

    Klaus Okkenhaug;Bart Vanhaesebroeck

  • Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

    Sally J Leevers;Bart Vanhaesebroeck;Michael D Waterfield;Michael D Waterfield

  • CLONING AND CHARACTERIZATION OF A G-PROTEIN-ACTIVATED HUMAN PHOSPHOINOSITIDE-3 KINASE

    Borislav Stoyanov;Stefano Volinia;Theodor Hanck;Ignacio Rubio

  • Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

    M P Wymann;G Bulgarelli-Leva;M J Zvelebil;L Pirola

  • Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

    P Rodriguez-Viciana;P H Warne;B Vanhaesebroeck;M D Waterfield

  • Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

    Mariona Graupera;Julie Guillermet-Guibert;Lazaros C. Foukas;Li-Kun Phng

  • Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

    Khaled Ali;Dalya R. Soond;Roberto Piñeiro;Thorsten Hagemann

  • p110δ, a novel phosphoinositide 3-kinase in leukocytes

    Bart Vanhaesebroeck;Melanie J. Welham;Kei Kotani;Rob Stein

  • Signalling by PI3K isoforms: insights from gene-targeted mice.

    Bart Vanhaesebroeck;Khaled Ali;Khaled Ali;Antonio Bilancio;Barbara Geering;Barbara Geering

  • Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

    Lazaros C. Foukas;Marc Claret;Wayne Pearce;Klaus Okkenhaug;Klaus Okkenhaug

  • Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

    Khaled Ali;Antonio Bilancio;Matthew Thomas;Wayne Pearce

Frequent Co-Authors

Klaus Okkenhaug
Klaus Okkenhaug University of Cambridge
Walter Fiers
Walter Fiers Ghent University
Robert K. Semple
Robert K. Semple University of Edinburgh
Gavin Y. Oudit
Gavin Y. Oudit University of Alberta
Michael D. Waterfield
Michael D. Waterfield Ludwig Cancer Research
Rudi Beyaert
Rudi Beyaert Ghent University
Anne J. Ridley
Anne J. Ridley University of Bristol
Mike Waterfield
Mike Waterfield Ludwig Cancer Research

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