The scientist’s investigation covers issues in Cell biology, Biochemistry, Insulin receptor, Phosphatidylinositol and Endosome. His Cell biology study combines topics from a wide range of disciplines, such as Endocytic cycle and EEA1. His study in Insulin receptor concentrates on IRS2 and Insulin receptor substrate.
The IRS2 study combines topics in areas such as Insulin Receptor Substrate Proteins, Tyrosine kinase and GRB10. His Phosphatidylinositol research entails a greater understanding of Kinase. The study incorporates disciplines such as Microtubule, Membrane transport, GTPase and Membrane docking in addition to Endosome.
Jonathan M. Backer spends much of his time researching Cell biology, Biochemistry, Insulin receptor, Kinase and Phosphatidylinositol. His Cell biology research includes themes of Receptor and Endocytic cycle. In his work, IRS1 is strongly intertwined with Insulin Receptor Substrate Proteins, which is a subfield of Biochemistry.
His Insulin receptor research integrates issues from Autophosphorylation and Tyrosine phosphorylation. His biological study deals with issues like Molecular biology, which deal with fields such as Wortmannin, Mutant, Cell migration, Motility and Epidermal growth factor. Phosphatidylinositol 3-Kinases is the focus of his Phosphatidylinositol research.
Jonathan M. Backer focuses on Cell biology, Receptor tyrosine kinase, PI3K/AKT/mTOR pathway, G protein-coupled receptor and Signal transduction. His Biochemistry research extends to the thematically linked field of Cell biology. Within one scientific family, Jonathan M. Backer focuses on topics pertaining to Integrin under Receptor tyrosine kinase, and may sometimes address concerns connected to Haptotaxis.
The concepts of his PI3K/AKT/mTOR pathway study are interwoven with issues in Carcinogenesis, Insulin and Kinase. His G protein-coupled receptor research is multidisciplinary, relying on both Heterotrimeric G protein, G protein, Protein subunit and GTPase. His work deals with themes such as Transport protein, Cancer research and BAG3, which intersect with Signal transduction.
His scientific interests lie mostly in Cell biology, Signal transduction, Chaperone-mediated autophagy, Computational biology and Autolysosome. As part of his studies on Cell biology, Jonathan M. Backer frequently links adjacent subjects like Insulin. The various areas that Jonathan M. Backer examines in his Signal transduction study include Cancer research, Protein subunit and BAG3.
His Chaperone-mediated autophagy study integrates concerns from other disciplines, such as BECN1 and Multicellular organism. His studies in Computational biology integrate themes in fields like MAP1LC3B, Sequestosome 1, Autophagosome and Physiology. Phagosome is a subfield of Biochemistry that Jonathan M. Backer tackles.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Xiao Jian Sun;P. Rothenberg;P. Rothenberg;C. R. Kahn;J. M. Backer.
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
J M Backer;M G Myers;S E Shoelson;D J Chin.
The EMBO Journal (1992)
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.
Yun Zhong;Qing Jun Wang;Qing Jun Wang;Xianting Li;Ying Yan.
Nature Cell Biology (2009)
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
Takahiro Nobukuni;Manel Joaquin;Manel Joaquin;Marta Roccio;Stephen G. Dann.
Proceedings of the National Academy of Sciences of the United States of America (2005)
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc : implications for insulin control of ras signalling
E Y Skolnik;C H Lee;A Batzer;L M Vicentini.
The EMBO Journal (1993)
The regulation and function of Class III PI3Ks: novel roles for Vps34
Jonathan M. Backer.
Biochemical Journal (2008)
Phosphatidylinositol-3-OH kinases are Rab5 effectors.
S Christoforidis;S Christoforidis;M Miaczynska;M Miaczynska;K Ashman;M Wilm.
Nature Cell Biology (1999)
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
Rutilio A. Fratti;Jonathan M. Backer;Jean Gruenberg;Silvia Corvera.
Journal of Cell Biology (2001)
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