World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
86
Citations
27179
World Ranking
14133
National Ranking
39

Overview

Mario J.A. Saad is affiliated with the State University of Campinas in Brazil and has conducted extensive research within the field of medicine, with a particular focus on physiology, surgery, molecular biology, health, toxicology and mutagenesis, and rehabilitation. Their work spans various aspects of metabolism, obesity, and health impacts related to environmental factors.

The scientist has contributed to multiple main topics of research, including:

  • Gut microbiota and health
  • Wound healing and treatments
  • Diet and metabolism studies
  • Regulation of appetite and obesity
  • Adipose tissue and metabolism
  • Air quality and health impacts
  • Climate change and health impacts

Their recent publications cover a range of issues involving metabolic conditions, environmental exposures, and biomaterials for wound care. Recent notable papers include:

  • "Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications" (2021) published in Diabetology & Metabolic Syndrome
  • "Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass" (2020) published in Obesity Surgery
  • "Maternal exposure to air pollution alters energy balance transiently according to gender and changes gut microbiota" (2023) published in Frontiers in Endocrinology
  • "Effects of Electrospun Fibrous Membranes of PolyCaprolactone and Chitosan/Poly(Ethylene Oxide) on Mouse Acute Skin Lesions" (2020) published in Polymers
  • "Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel" (2023) published in Brazilian Journal of Medical and Biological Research

Frequent coauthors in their work include:

  • Andrey Santos
  • Dioze Guadagnini
  • Patrícia O. Prada
  • Heloísa Balan Assalin
  • Maria Helena Melo Lima

Mario J.A. Saad has published multiple articles in venues such as:

  • Frontiers in Endocrinology
  • Polymers
  • Food Research International
  • Diabetology & Metabolic Syndrome
  • Obesity Surgery

The scientist's research integrates diverse disciplines to investigate complex interactions between metabolic health, environmental factors, and therapeutic approaches, with a particular emphasis on molecular and physiological mechanisms.

Best Publications

  • Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

    Cláudio T. De Souza;Eliana P. Araujo;Silvana Bordin;Rika Ashimine

  • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

    Marciane Milanski;Giovanna Degasperi;Andressa Coope;Joseane Morari

  • Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

    Daniela M.L. Tsukumo;Marco A. Carvalho-Filho;José B.C. Carvalheira;Patrícia O. Prada

  • Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance.

    M. J. A. Saad;A. Santos;P. O. Prada

  • TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study.

    Ana Carolina Junqueira Vasques;Fernanda Satake Novaes;Maria da Saúde de Oliveira;José Roberto Matos Souza

  • High-fat diet induces apoptosis of hypothalamic neurons.

    Juliana C. Moraes;Andressa Coope;Joseane Morari;Dennys E. Cintra

  • Cross-talk between the insulin and angiotensin signaling systems.

    L. A. Velloso;F. Folli;X. J. Sun;M. F. White

  • IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

    Eduardo R. Ropelle;Marcelo B. Flores;Dennys E. Cintra;Guilherme Z. Rocha

  • Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

    Dennys E. Cintra;Eduardo R. Ropelle;Juliana C. Moraes;José R. Pauli

  • Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

    M. J. A. Saad;F. Folli;J. A. Kahn;C. R. Kahn

  • Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

    M. J. A. Saad;E. Araki;M. Miralpeix;P. L. Rothenberg

  • Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice

    B. M. Carvalho;D. Guadagnini;D. M L Tsukumo;A. A. Schenka

  • Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

    Guilherme Z Rocha;Marília M Dias;Eduardo R Ropelle;Felipe Osório-Costa

  • Retraction: Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice.

    Andréa M. Caricilli;Paty K. Picardi;Lélia L. de Abreu;Mirian Ueno

  • S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

    Marco A. Carvalho-Filho;Mirian Ueno;Sandro M. Hirabara;Amedea B. Seabra

  • Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

    F. Folli;M. J. A. Saad;J. M. Backer;C. R. Kahn

  • Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats

    Cro Carvalho;SL Brenelli;AC Silva;Alb Nunes

  • Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

    F. Folli;M. J. A. Saad;J. M. Backer;C. R. Kahn

  • TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation

    Licio A. Velloso;Franco Folli;Franco Folli;Mario J. Saad

  • Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

    Marciane Milanski;Ana P. Arruda;Andressa Coope;Letícia M. Ignacio-Souza

Frequent Co-Authors

Lício A. Velloso
Lício A. Velloso State University of Campinas
Franco Folli
Franco Folli University of Milan
Rui Curi
Rui Curi Universidade de São Paulo
Iscia Lopes-Cendes
Iscia Lopes-Cendes State University of Campinas
Morris F. White
Morris F. White Boston Children's Hospital
Jonathan M. Backer
Jonathan M. Backer Albert Einstein College of Medicine
Fernando F. Costa
Fernando F. Costa State University of Campinas
José Cipolla-Neto
José Cipolla-Neto Universidade de São Paulo

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