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Jens C. Brüning

Jens C. Brüning

D-Index & Metrics

Medicine

D-Index
110
Citations
45214
World Ranking
5559
National Ranking
308

Overview

Jens C. Brüning is affiliated with the Max Planck Society in Germany. Their research focuses primarily on areas spanning medicine, neuroscience, and biochemistry, genetics, and molecular biology. Within these expansive fields, their work delves into subfields such as molecular biology, endocrine and autonomic systems, physiology, nutrition and dietetics, and surgery.

The scientist's research covers several main topics including:

  • Regulation of Appetite and Obesity
  • Adipose Tissue and Metabolism
  • Biochemical Analysis and Sensing Techniques
  • Pancreatic function and diabetes
  • Diet and metabolism studies
  • Sleep and Wakefulness Research
  • Sphingolipid Metabolism and Signaling

Notable recent publications by Jens C. Brüning include:

  • "Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing" (2021), published in Cell Metabolism
  • "HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus" (2022), published in Nature Metabolism
  • "Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus" (2021), published in Endocrine Reviews
  • "POMC neuronal heterogeneity in energy balance and beyond: an integrated view" (2021), published in Nature Metabolism
  • "The role of ceramides in metabolic disorders: when size and localization matters" (2020), published in Nature Reviews Endocrinology

The scientist has frequently published in venues such as:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism
  • Nature Metabolism
  • Molecular Metabolism

Collaborations have played a significant role in their research output, with prominent co-authors including:

  • Lukas Steuernagel
  • Paul Klemm
  • F. Thomas Wunderlich
  • Peter Kloppenburg
  • Alexander Jaïs

Best Publications

  • Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

    Jens C. Brüning;Dinesh Gautam;Deborah J. Burks;Jennifer Gillette

  • Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

    R N Kulkarni;J C Brüning;J N Winnay;C Postic

  • A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

    Jens C Brüning;M.Dodson Michael;Jonathon N Winnay;Tatsuya Hayashi

  • Interleukin-10 signaling in regulatory T cells Is required for suppression of Th17 cell-mediated inflammation

    Ashutosh Chaudhry;Robert M. Samstein;Piper Treuting;Yuqiong Liang

  • Inactivation of the Fto gene protects from obesity

    Julia Fischer;Linda Koch;Linda Koch;Christian Emmerling;Jeanette Vierkotten;Jeanette Vierkotten

  • Agouti-related peptide-expressing neurons are mandatory for feeding.

    Eva Gropp;Marya Shanabrough;Erzsebet Borok;Allison W Xu

  • A guide to analysis of mouse energy metabolism

    Matthias H Tschöp;John R Speakman;John R Speakman;Jonathan R S Arch;Johan Auwerx

  • Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

    Keertik Fulzele;Ryan C. Riddle;Douglas J. DiGirolamo;Xuemei Cao

  • Overexpression of Fto leads to increased food intake and results in obesity.

    Chris Church;Lee Moir;Fiona McMurray;Christophe Girard

  • Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

    Jan Mauer;Bhagirath Chaurasia;Julia Goldau;Merly C Vogt

  • Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

    A Christine Konner;Ruth Janoschek;Leona Plum;Sabine Jordan

  • Role for neuronal insulin resistance in neurodegenerative diseases

    M. Schubert;D. Gautam;D. Surjo;Kazuhiro Ueki

  • The role of insulin receptor signaling in the brain.

    Leona Plum;Markus Schubert;Jens C. Brüning

  • Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.

    Katharina Timper;Jens Claus Brüning

  • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

    Jens C Brüning;Jonathon Winnay;Susan Bonner-Weir;Simeon I Taylor

  • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

    Yoshiaki Kido;Deborah J. Burks;Dominic Withers;Jens C. Bruning

  • Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

    Sarah M. Turpin;Hayley T. Nicholls;Diana M. Willmes;Arnaud Mourier

  • Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

    Sabine D. Jordan;Markus Krüger;Diana M. Willmes;Nora Redemann

  • MyD88 signaling in the CNS is required for development of fatty acid induced leptin resistance and diet-induced obesity

    André Kleinridders;André Kleinridders;Dominik Schenten;A. Christine Könner;A. Christine Könner;Bengt F. Belgardt;Bengt F. Belgardt

  • Central insulin action in energy and glucose homeostasis

    Leona Plum;Bengt F. Belgardt;Jens C. Brüning

Frequent Co-Authors

Peter Kloppenburg
Peter Kloppenburg University of Cologne
Tamas L. Horvath
Tamas L. Horvath Yale University
C. Ronald Kahn
C. Ronald Kahn Harvard University
Marc Tittgemeyer
Marc Tittgemeyer Max Planck Society
Thomas Langer
Thomas Langer Max Planck Society
Frances M. Ashcroft
Frances M. Ashcroft University of Oxford
Tony Tiganis
Tony Tiganis Peter MacCallum Cancer Centre
Michael A. Cowley
Michael A. Cowley Monash University
Manolis Pasparakis
Manolis Pasparakis University of Cologne
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center

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