World's Best Scientists 2026 revealed!
Thomas Langer

Thomas Langer

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
110
Citations
38603
World Ranking
977
National Ranking
65

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Thomas Langer is affiliated with the Max Planck Society in Germany and specializes in research within biochemistry, genetics, and molecular biology, with a particular focus on molecular biology and cell biology subfields. Their work consistently addresses topics related to mitochondrial function and pathology, ATP synthase and ATPases research, and metabolism and genetic disorders. Additional thematic areas include endoplasmic reticulum stress and disease, RNA modifications and cancer, autophagy in disease and therapy, and adipose tissue and metabolism.

Recent notable publications by Thomas Langer encompass a variety of subjects linked to mitochondrial biology, with articles appearing in prominent scientific journals. These include:

  • "MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control," 2021, Nature Cell Biology
  • "Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity," 2020, Annual Review of Biochemistry
  • "Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing," 2021, Cell Metabolism
  • "OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy," 2022, Cell Metabolism
  • "Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity," 2021, Nature Metabolism

Thomas Langer collaborates frequently with several other researchers. Regular co-authors include:

  • Hendrik Nolte
  • Patrick Giavalisco
  • Takashi Tatsuta
  • Thomas MacVicar
  • Elena I. Rugarli

Their publication record spans various respected venues, with a significant number of contributions to journals and archives such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cell Biology
  • Cell Metabolism
  • The EMBO Journal
  • Cell Reports

Thomas Langer's research intersects multiple disciplines, including medicine and clinical biochemistry, epidemiology, and physiology, reflecting a broad approach to understanding molecular and cellular mechanisms relevant to health and disease.

Best Publications

  • Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

    T. Langer;Chi Lu;H. Echols;J. Flanagan

  • Mitochondrial Dynamics and Metabolic Regulation.

    Timothy Wai;Thomas Langer

  • Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

    J Martin;T Langer;R Boteva;A Schramel

  • SLP‐2 is required for stress‐induced mitochondrial hyperfusion

    Daniel Tondera;Stéphanie Grandemange;Alexis Jourdain;Mariusz Karbowski

  • The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

    Ruchika Anand;Timothy Wai;Michael J. Baker;Nikolay Kladt

  • DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

    H. Schröder;T. Langer;F.U. Hartl;B. Bukau

  • The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE

    A Szabo;T Langer;T Langer;H Schröder;J Flanagan

  • Making heads or tails of phospholipids in mitochondria

    Christof Osman;Dennis R. Voelker;Thomas Langer;Thomas Langer

  • DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

    Douglas M. Cyr;Thomas Langer;Michael G. Douglas

  • Quality control of mitochondria: protection against neurodegeneration and ageing

    Takashi Tatsuta;Thomas Langer

  • Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

    Carsten Merkwirth;Sascha Dargazanli;Takashi Tatsuta;Stefan Geimer

  • Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

    Sarah Ehses;Ines Raschke;Giuseppe Mancuso;Andrea Bernacchia

  • Molecular chaperones in protein folding: the art of avoiding sticky situations

    Franz-Ulrich Hartl;Roman Hlodan;Thomas Langer

  • Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.

    T. Langer;G. Pfeifer;J. Martin;W. Baumeister

  • New roles for mitochondrial proteases in health, ageing and disease

    Pedro M. Quirós;Thomas Langer;Carlos López-Otín

  • OPA1 processing in cell death and disease – the long and short of it

    Thomas MacVicar;Thomas Langer

  • Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

    Timothy Wai;Jaime García-Prieto;Michael J. Baker;Carsten Merkwirth

  • Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.

    Carsten Merkwirth;Thomas Langer

  • Mitochondrial quality control: a matter of life and death for neurons

    Elena I Rugarli;Thomas Langer;Thomas Langer

  • The m-AAA Protease Defective in Hereditary Spastic Paraplegia Controls Ribosome Assembly in Mitochondria

    Mark Nolden;Sarah Ehses;Mirko Koppen;Andrea Bernacchia

Frequent Co-Authors

Walter Neupert
Walter Neupert Max Planck Institute of Biochemistry
Elena I. Rugarli
Elena I. Rugarli University of Cologne
Harald Schwalbe
Harald Schwalbe Goethe University Frankfurt
Günter Helmchen
Günter Helmchen Heidelberg University
Jens C. Brüning
Jens C. Brüning Max Planck Society
Benedikt Westermann
Benedikt Westermann University of Bayreuth
Marcus Krüger
Marcus Krüger University of Cologne
Britta Brügger
Britta Brügger Heidelberg University
Linda Partridge
Linda Partridge Max Planck Society
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute

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