Douglas M. Cyr

Overview

Best Publications

• The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

  G C Meacham;C Patterson;W Zhang;J M Younger

  1037
  Citations

• CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.

  Jihong Jiang;Jihong Jiang;Carol A. Ballinger;Yaxu Wu;Qian Dai

  734
  Citations

• DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

  Douglas M. Cyr;Thomas Langer;Michael G. Douglas

  638
  Citations

• The J‐protein family: modulating protein assembly, disassembly and translocation

  Peter Walsh;Dejan Bursac;Yin Chern Law;Douglas Cyr

  612
  Citations

• From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

  Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  559
  Citations

• Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.

  J. Michael Younger;Liling Chen;Hong Yu Ren;Meredith F.N. Rosser

  511
  Citations

• Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

  Douglas M Cyr;Jörg Höhfeld;Cam Patterson

  437
  Citations

• From the cradle to the grave: molecular chaperones that may choose between folding and degradation.

  Jörg Höhfeld;Douglas M. Cyr;Cam Patterson

  433
  Citations

• Mechanisms for regulation of Hsp70 function by Hsp40.

  Chun Yang Fan;Soojin Lee;Douglas M. Cyr

  423
  Citations

• THE HDJ-2/HSC70 CHAPERONE PAIR FACILITATES EARLY STEPS IN CFTR BIOGENESIS

  Geoffrey C. Meacham;Zhen Lu;Scott King;Eric Sorscher

  417
  Citations

• CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

  Shu Bing Qian;Holly McDonough;Frank Boellmann;Douglas M. Cyr

  408
  Citations

• YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.

  Avrom J. Caplan;Douglas M. Cyr;Michael G. Douglas

  396
  Citations

• CHIP activates HSF1 and confers protection against apoptosis and cellular stress

  Qian Dai;Chunlian Zhang;Yaxu Wu;Holly McDonough

  365
  Citations

• The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria.

  Christian Ungermann;Walter Neupert;Douglas M. Cyr

  334
  Citations

• Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

  Douglas M. Cyr;Xiangyang Lu;Michael G. Douglas

  333
  Citations

• VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

  Hong Yu Ren;Diane E. Grove;Oxana De La Rosa;Scott A. Houck

  324
  Citations

• Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.

  Avrom J. Caplan;Douglas M. Cyr;Michael G. Douglas

  302
  Citations

• Protein Folding Activity of Hsp70 Is Modified Differentially by the Hsp40 Co-chaperones Sis1 and Ydj1

  Zhen Lu;Douglas M. Cyr

  283
  Citations

• Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

  Daisuke Morito;Kazuyoshi Hirao;Yukako Oda;Nobuko Hosokawa

  262
  Citations

• A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

  J. Michael Younger;Hong Yu Ren;Liling Chen;Chun Yang Fan

  252
  Citations