What is he best known for?
The fields of study he is best known for:
His primary areas of investigation include Cell biology, Chaperone, Protein folding, Biochemistry and Heat shock protein.
His Cell biology research is multidisciplinary, incorporating elements of STUB1, Ubiquitin, Ubiquitin ligase and Hsp33.
His Chaperone research includes elements of Hsp70 and Protein family.
His research integrates issues of DNAJ Protein, Protein structure, Cystic fibrosis transmembrane conductance regulator and Co-chaperone in his study of Protein folding.
His work carried out in the field of Co-chaperone brings together such families of science as JUNQ and IPOD and Protein degradation.
His Heat shock protein research incorporates elements of Plasma protein binding and Escherichia coli.
His most cited work include:
- The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation (729 citations)
- CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. (499 citations)
- DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70 (412 citations)
What are the main themes of his work throughout his whole career to date?
Douglas M. Cyr mainly focuses on Cell biology, Biochemistry, Protein folding, Chaperone and Endoplasmic reticulum.
His study in Cell biology is interdisciplinary in nature, drawing from both Ubiquitin, Ubiquitin ligase, Cytosol and Hsp70, Co-chaperone.
His Ubiquitin study which covers Proteasome that intersects with STUB1.
His Protein folding study combines topics in areas such as Biophysics, JUNQ and IPOD, Peptide sequence, Cystic fibrosis transmembrane conductance regulator and Protein structure.
His Chaperone research incorporates themes from Heat shock protein, Protein degradation, Protein family, Hsp33 and DNAJ Protein.
The various areas that Douglas M. Cyr examines in his Endoplasmic reticulum study include Signal transduction and Membrane protein.
He most often published in these fields:
- Cell biology (59.62%)
- Biochemistry (49.04%)
- Protein folding (38.46%)
What were the highlights of his more recent work (between 2013-2021)?
- Cell biology (59.62%)
- Cystic fibrosis (11.54%)
- Cystic fibrosis transmembrane conductance regulator (14.42%)
In recent papers he was focusing on the following fields of study:
Douglas M. Cyr mainly investigates Cell biology, Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Biochemistry and Endoplasmic reticulum.
His studies deal with areas such as Hsp70, Cellular homeostasis and Membrane protein as well as Cell biology.
His work in Hsp70 covers topics such as Prefoldin which are related to areas like Chaperone.
His Chaperone research is multidisciplinary, incorporating perspectives in Unfolded protein response, Computational biology and Proteasome.
His research investigates the connection with Cystic fibrosis and areas like Bioinformatics which intersect with concerns in Missense mutation, Ivacaftor and ΔF508.
The Cystic fibrosis transmembrane conductance regulator study combines topics in areas such as Potentiator and Pathology.
Between 2013 and 2021, his most popular works were:
- From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. (233 citations)
- Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. (93 citations)
- Specification of Hsp70 Function by Type I and Type II Hsp40 (43 citations)
In his most recent research, the most cited papers focused on:
Douglas M. Cyr mostly deals with Cell biology, Chaperone, Heat shock protein, Genetics and Computational biology.
His Cell biology research is multidisciplinary, incorporating elements of Protein structure, Proteome and Membrane protein.
His research in Chaperone intersects with topics in Proteotoxicity, Protein folding, Hsp70, Prefoldin and Cellular homeostasis.
His Heat shock protein research integrates issues from Proteostasis, Cell aging and Transcription.
In most of his Genetics studies, his work intersects topics such as Bioinformatics.
His Computational biology study integrates concerns from other disciplines, such as Protein function, Protein refolding and Protein domain.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
