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Douglas M. Cyr

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
15369
World Ranking
13628
National Ranking
5781

Douglas M. Cyr publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Douglas M. Cyr sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 120 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Douglas M. Cyr D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Douglas M. Cyr sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 57 D-Index — 31st percentile

31% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Douglas M. Cyr is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research is situated primarily within the domain of Biochemistry, Genetics, and Molecular Biology, contributing significantly to subfields such as Molecular Biology, Cell Biology, Epidemiology, Physiology, and Computational Theory and Mathematics.

The scientist's recent publications reflect a concentration on protein biology, cellular stress responses, and molecular chaperones. Notable papers include:

  • "J-domain protein chaperone circuits in proteostasis and disease" (2022) published in Trends in Cell Biology
  • "CHIP Is a U-box-dependent E3 Ubiquitin Ligase: IDENTIFICATION OF Hsc70 AS A TARGET FOR UBIQUITYLATION" (2021) published in UNC Libraries
  • "Specification of Hsp70 Function by Hsp40 Co-chaperones" (2022) published in Sub-cellular biochemistry/Subcellular biochemistry
  • "J-domain proteins: From molecular mechanisms to diseases" (2024) published in Cell Stress and Chaperones
  • "CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70" (2020) published in UNC Libraries

The main research topics evident from their body of work include:

  • Heat shock proteins research
  • Endoplasmic Reticulum Stress and Disease
  • Protein Structure and Dynamics
  • Autophagy in Disease and Therapy
  • Computational Drug Discovery Methods
  • Mitochondrial Function and Pathology
  • Ubiquitin and proteasome pathways

Frequent collaborators in their research encompass a group of coauthors with whom Cyr has published multiple times. These include:

  • Hong Yu Ren
  • Cam Patterson
  • Daniel W. Summers
  • Carlos H.I. Ramos
  • Scott A. Houck

Douglas M. Cyr has contributed extensively to UNC Libraries, which is the primary venue for their research publications. Additional venues include Trends in Cell Biology, Sub-cellular biochemistry/Subcellular biochemistry, and Cell Stress and Chaperones, indicating active engagement with diverse scientific outlets related to cell biology and molecular chaperones.

Best Publications

  • The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

    G C Meacham;C Patterson;W Zhang;J M Younger

  • CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.

    Jihong Jiang;Jihong Jiang;Carol A. Ballinger;Yaxu Wu;Qian Dai

  • DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

    Douglas M. Cyr;Thomas Langer;Michael G. Douglas

  • The J‐protein family: modulating protein assembly, disassembly and translocation

    Peter Walsh;Dejan Bursac;Yin Chern Law;Douglas Cyr

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

    Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  • Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.

    J. Michael Younger;Liling Chen;Hong Yu Ren;Meredith F.N. Rosser

  • Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

    Douglas M Cyr;Jörg Höhfeld;Cam Patterson

  • From the cradle to the grave: molecular chaperones that may choose between folding and degradation.

    Jörg Höhfeld;Douglas M. Cyr;Cam Patterson

  • Mechanisms for regulation of Hsp70 function by Hsp40.

    Chun Yang Fan;Soojin Lee;Douglas M. Cyr

  • THE HDJ-2/HSC70 CHAPERONE PAIR FACILITATES EARLY STEPS IN CFTR BIOGENESIS

    Geoffrey C. Meacham;Zhen Lu;Scott King;Eric Sorscher

  • CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

    Shu Bing Qian;Holly McDonough;Frank Boellmann;Douglas M. Cyr

  • YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.

    Avrom J. Caplan;Douglas M. Cyr;Michael G. Douglas

  • CHIP activates HSF1 and confers protection against apoptosis and cellular stress

    Qian Dai;Chunlian Zhang;Yaxu Wu;Holly McDonough

  • The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria.

    Christian Ungermann;Walter Neupert;Douglas M. Cyr

  • Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

    Douglas M. Cyr;Xiangyang Lu;Michael G. Douglas

  • VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

    Hong Yu Ren;Diane E. Grove;Oxana De La Rosa;Scott A. Houck

  • Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.

    Avrom J. Caplan;Douglas M. Cyr;Michael G. Douglas

  • Protein Folding Activity of Hsp70 Is Modified Differentially by the Hsp40 Co-chaperones Sis1 and Ydj1

    Zhen Lu;Douglas M. Cyr

  • Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

    Daisuke Morito;Kazuyoshi Hirao;Yukako Oda;Nobuko Hosokawa

  • A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

    J. Michael Younger;Hong Yu Ren;Liling Chen;Chun Yang Fan

Frequent Co-Authors

Cam Patterson
Cam Patterson University of Arkansas for Medical Sciences
Walter Neupert
Walter Neupert Max Planck Institute of Biochemistry
Elizabeth A. Craig
Elizabeth A. Craig University of Wisconsin–Madison
Christian Ungermann
Christian Ungermann Osnabrück University
Scott H. Randell
Scott H. Randell University of North Carolina at Chapel Hill
Kazuhiro Nagata
Kazuhiro Nagata Kyoto Sangyo University
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Matt Kaeberlein
Matt Kaeberlein University of Washington
Susan Lindquist
Susan Lindquist MIT
Jeffrey N. Strathern
Jeffrey N. Strathern National Institutes of Health

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Best Scientists Citing Douglas M. Cyr

Jeffrey L. Brodsky

Jeffrey L. Brodsky

University of Pittsburgh

Publications: 91

Walter Neupert

Walter Neupert

Max Planck Institute of Biochemistry

Publications: 63

Cam Patterson

Cam Patterson

University of Arkansas for Medical Sciences

Publications: 49

Jason E. Gestwicki

Jason E. Gestwicki

University of California, San Francisco

Publications: 44

Bernd Bukau

Bernd Bukau

Heidelberg University

Publications: 41

Gergely L. Lukacs

Gergely L. Lukacs

McGill University

Publications: 41

Elizabeth A. Craig

Elizabeth A. Craig

University of Wisconsin–Madison

Publications: 40

Nikolaus Pfanner

Nikolaus Pfanner

University of Freiburg

Publications: 40

Margarida D. Amaral

Margarida D. Amaral

University of Lisbon

Publications: 33

Gregory L. Blatch

Gregory L. Blatch

University of Notre Dame Australia

Publications: 32

Susan Lindquist

Susan Lindquist

MIT

Publications: 31

F. Ulrich Hartl

F. Ulrich Hartl

Max Planck Society

Publications: 28

William E. Balch

William E. Balch

Scripps Health

Publications: 27

Christine E. Bear

Christine E. Bear

University of Toronto

Publications: 25

Luis J. V. Galietta

Luis J. V. Galietta

Telethon Institute Of Genetics And Medicine

Publications: 23

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Wolfgang Voos

University of Bonn

Publications: 23

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