His primary areas of investigation include Cell biology, Chaperone, Protein folding, Biochemistry and Heat shock protein. His Cell biology research is multidisciplinary, incorporating elements of STUB1, Ubiquitin, Ubiquitin ligase and Hsp33. His Chaperone research includes elements of Hsp70 and Protein family.
His research integrates issues of DNAJ Protein, Protein structure, Cystic fibrosis transmembrane conductance regulator and Co-chaperone in his study of Protein folding. His work carried out in the field of Co-chaperone brings together such families of science as JUNQ and IPOD and Protein degradation. His Heat shock protein research incorporates elements of Plasma protein binding and Escherichia coli.
Douglas M. Cyr mainly focuses on Cell biology, Biochemistry, Protein folding, Chaperone and Endoplasmic reticulum. His study in Cell biology is interdisciplinary in nature, drawing from both Ubiquitin, Ubiquitin ligase, Cytosol and Hsp70, Co-chaperone. His Ubiquitin study which covers Proteasome that intersects with STUB1.
His Protein folding study combines topics in areas such as Biophysics, JUNQ and IPOD, Peptide sequence, Cystic fibrosis transmembrane conductance regulator and Protein structure. His Chaperone research incorporates themes from Heat shock protein, Protein degradation, Protein family, Hsp33 and DNAJ Protein. The various areas that Douglas M. Cyr examines in his Endoplasmic reticulum study include Signal transduction and Membrane protein.
Douglas M. Cyr mainly investigates Cell biology, Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Biochemistry and Endoplasmic reticulum. His studies deal with areas such as Hsp70, Cellular homeostasis and Membrane protein as well as Cell biology. His work in Hsp70 covers topics such as Prefoldin which are related to areas like Chaperone.
His Chaperone research is multidisciplinary, incorporating perspectives in Unfolded protein response, Computational biology and Proteasome. His research investigates the connection with Cystic fibrosis and areas like Bioinformatics which intersect with concerns in Missense mutation, Ivacaftor and ΔF508. The Cystic fibrosis transmembrane conductance regulator study combines topics in areas such as Potentiator and Pathology.
Douglas M. Cyr mostly deals with Cell biology, Chaperone, Heat shock protein, Genetics and Computational biology. His Cell biology research is multidisciplinary, incorporating elements of Protein structure, Proteome and Membrane protein. His research in Chaperone intersects with topics in Proteotoxicity, Protein folding, Hsp70, Prefoldin and Cellular homeostasis.
His Heat shock protein research integrates issues from Proteostasis, Cell aging and Transcription. In most of his Genetics studies, his work intersects topics such as Bioinformatics. His Computational biology study integrates concerns from other disciplines, such as Protein function, Protein refolding and Protein domain.
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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
Geoffrey C. Meacham;Cam Patterson;Wenyue Zhang;J. Michael Younger.
Nature Cell Biology (2001)
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.
Jihong Jiang;Jihong Jiang;Carol A. Ballinger;Yaxu Wu;Qian Dai.
Journal of Biological Chemistry (2001)
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70
Douglas M. Cyr;Thomas Langer;Michael G. Douglas.
Trends in Biochemical Sciences (1994)
The J‐protein family: modulating protein assembly, disassembly and translocation
Peter Walsh;Dejan Bursac;Yin Chern Law;Douglas Cyr.
EMBO Reports (2004)
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.
J. Michael Younger;Liling Chen;Hong Yu Ren;Meredith F.N. Rosser.
From the cradle to the grave: molecular chaperones that may choose between folding and degradation.
Jörg Höhfeld;Douglas M. Cyr;Cam Patterson.
EMBO Reports (2001)
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold
Douglas M Cyr;Jörg Höhfeld;Cam Patterson.
Trends in Biochemical Sciences (2002)
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.
Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck.
Molecular Biology of the Cell (2016)
THE HDJ-2/HSC70 CHAPERONE PAIR FACILITATES EARLY STEPS IN CFTR BIOGENESIS
Geoffrey C. Meacham;Zhen Lu;Scott King;Eric Sorscher.
The EMBO Journal (1999)
Mechanisms for regulation of Hsp70 function by Hsp40.
Chun Yang Fan;Soojin Lee;Douglas M. Cyr.
Cell Stress & Chaperones (2003)
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