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Margarida D. Amaral

Margarida D. Amaral

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Molecular Biology
Portugal
2026

D-Index & Metrics

Molecular Biology

D-Index
54
Citations
9778
World Ranking
2329
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Portugal Leader Award
  • 2025 - Research.com Molecular Biology in Portugal Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Margarida D. Amaral is affiliated with the University of Lisbon in Portugal. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a concentration in pulmonary and respiratory medicine, molecular biology, genetics, and physiology.

The scientist's work extensively covers topics related to cystic fibrosis research advances, neonatal respiratory health, advanced biosensing and bioanalysis techniques, tracheal and airway disorders, genomics and rare diseases, asthma and respiratory diseases, and pharmaceutical studies and practices.

Notable recent publications include:

  • Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids, 2020, STAR Protocols
  • What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?, 2020, International Journal of Molecular Sciences
  • Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition, 2020, Cell Death and Disease
  • A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles, 2020, Cellular and Molecular Life Sciences
  • Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis, 2021, Journal of Experimental Pharmacology

The scientist frequently publishes in venues such as the Journal of Cystic Fibrosis, International Journal of Molecular Sciences, Cells, Zenodo (CERN European Organization for Nuclear Research), and Hematology Transfusion and Cell Therapy.

Frequent collaborators include Iris A. L. Silva, Ines Pankonien, Violeta Railean, Miquéias Lopes-Pacheco, and Carlos M. Farinha.

Margarida D. Amaral is a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene

    Patrick R Sosnay;Karen R Siklosi;Fredrick Van Goor;Kyle Kaniecki;Kyle Kaniecki

  • Progress in Therapies for Cystic Fibrosis

    Kris De Boeck;Margarida D Amaral

  • Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei

    Daniele Zink;Margarida D. Amaral;Andreas Englmann;Susanne Lang

  • “CFTR Modulator Theratyping: Current Status, Gaps and Future Directions”

    John Paul Clancy;Calvin U. Cotton;Scott H. Donaldson;George M. Solomon

  • Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.

    Carlos M. Farinha;Margarida D. Amaral

  • New pharmacological approaches for cystic fibrosis: Promises, progress, pitfalls

    Scott C. Bell;Kris De Boeck;Margarida D. Amaral

  • Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis.

    Anabela S. Ramalho;Sebastian Beck;Michelle Meyer;Deborah Penque

  • CFTR and chaperones: processing and degradation.

    Margarida D. Amaral

  • Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis

    Margarida D. Amaral;Karl Kunzelmann

  • The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70.

    Carlos M. Farinha;Carlos M. Farinha;Paulo Nogueira;Filipa Mendes;Deborah Penque

  • Revertants, Low Temperature, and Correctors Reveal the Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction

    Carlos M. Farinha;John King-Underwood;Marisa Sousa;Ana Raquel Correia

  • CFTR Cl− channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis

    Stephanie Hirtz;Tanja Gonska;Hans H. Seydewitz;Jörg Thomas

  • Processing of CFTR: traversing the cellular maze--how much CFTR needs to go through to avoid cystic fibrosis?

    Margarida D. Amaral

  • Epithelial Chloride Transport by CFTR Requires TMEM16A

    Roberta Benedetto;Jiraporn Ousingsawat;Podchanart Wanitchakool;Yong Zhang

  • Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.

    Mónica Roxo-Rosa;Zhe Xu;André Schmidt;Mário Neto

  • Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients.

    M. D. Amaral

  • A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

    M. Catarina Silva;Susan Fox;Monica Beam;Happy Thakkar

  • Magnetic field-assisted DNA hybridisation and simultaneous detection using micron-sized spin-valve sensors and magnetic nanoparticles

    D.L. Graham;H.A. Ferreira;N. Feliciano;P.P. Freitas

  • Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

    Susana M. Garcia;M. Olivia Casanueva;M. Catarina Silva;M. Catarina Silva;Margarida D. Amaral;Margarida D. Amaral

  • Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells.

    Deborah Penque;Filipa Mendes;Sebastian Beck;Carlos Farinha

Frequent Co-Authors

Karl Kunzelmann
Karl Kunzelmann University of Regensburg
Rainer Schreiber
Rainer Schreiber University of Regensburg
Paulo P. Freitas
Paulo P. Freitas International Iberian Nanotechnology Laboratory
Milan Macek
Milan Macek Charles University
Marcus A. Mall
Marcus A. Mall Charité - University Medicine Berlin
Aleksander Edelman
Aleksander Edelman Université Paris Cité
Rainer Pepperkok
Rainer Pepperkok European Molecular Biology Laboratory
Ann Harris
Ann Harris Case Western Reserve University
Garry R. Cutting
Garry R. Cutting Johns Hopkins University School of Medicine
Gergely L. Lukacs
Gergely L. Lukacs McGill University

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