D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Molecular Biology D-index 59 Citations 10,337 194 World Ranking 1375 National Ranking 701

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis, Cell biology, Molecular biology and Endocrinology are his primary areas of study. His research in Cystic fibrosis transmembrane conductance regulator intersects with topics in Integral membrane protein, Chloride channel, Potentiator and Phosphorylation. His biological study spans a wide range of topics, including Mutant, Immunology, Bioinformatics and Pathology.

He interconnects Exocytosis and Endocytosis in the investigation of issues within Cell biology. His Molecular biology research integrates issues from Purine nucleoside phosphorylase, Cell culture, Cell and Gene delivery. His Endocrinology research includes elements of Epithelium, Internal medicine and Knockout rat.

His most cited work include:

  • Characterization and Dynamics of Aggresome Formation by a Cytosolic Gfp-Chimera✪ (546 citations)
  • Regulation of plasma membrane recycling by CFTR (305 citations)
  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. (233 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis, Molecular biology, Cell biology and Biochemistry. Cystic fibrosis transmembrane conductance regulator is a subfield of Internal medicine that Eric J. Sorscher investigates. Eric J. Sorscher has researched Cystic fibrosis in several fields, including Bioinformatics, Mutation, Immunology, Pathology and Lung.

His Molecular biology research includes themes of Cell culture, Transfection, Cell, Mutant and Genetic enhancement. Eric J. Sorscher has included themes like Protein structure, Integral membrane protein and Endocytosis in his Cell biology study. In his research on the topic of Mucociliary clearance, In vivo and Transepithelial chloride transport is strongly related with Pharmacology.

He most often published in these fields:

  • Cystic fibrosis transmembrane conductance regulator (45.56%)
  • Cystic fibrosis (41.11%)
  • Molecular biology (28.33%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cystic fibrosis (41.11%)
  • Cystic fibrosis transmembrane conductance regulator (45.56%)
  • Cell biology (24.44%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Cell biology, Cancer research and Ivacaftor. His Cystic fibrosis research is multidisciplinary, incorporating elements of Precision medicine, Function, Intensive care medicine, Muscle hypertrophy and Lung disease. His Cystic fibrosis transmembrane conductance regulator study combines topics from a wide range of disciplines, such as Chloride channel, Bioinformatics and Missense mutation.

His studies in Cell biology integrate themes in fields like Protein structure, Oxidative stress, Patch clamp and Transmembrane protein. In Cancer research, he works on issues like Purine nucleoside phosphorylase, which are connected to Adenosine, Molecular biology and Escherichia coli. The various areas that Eric J. Sorscher examines in his Ivacaftor study include Mutant, Potentiator, Disease, Pathology and Rat model.

Between 2017 and 2021, his most popular works were:

  • “CFTR Modulator Theratyping: Current Status, Gaps and Future Directions” (82 citations)
  • Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. (67 citations)
  • Development of an airway mucus defect in the cystic fibrosis rat (53 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Eric J. Sorscher mainly focuses on Cystic fibrosis, Lumacaftor, Ivacaftor, Precision medicine and Bioinformatics. Cystic fibrosis is the subject of his research, which falls under Internal medicine. His Lumacaftor research is multidisciplinary, relying on both Ribosome and Transmembrane protein.

Eric J. Sorscher combines subjects such as Disease, Mutant and Potentiator with his study of Ivacaftor. The study incorporates disciplines such as Gating, Long-term potentiation, Wild type and Phosphorylation, Cell biology in addition to Disease. The concepts of his Bioinformatics study are interwoven with issues in Cftr modulator, Respiratory tree and Cystic fibrosis transmembrane conductance regulator.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Characterization and Dynamics of Aggresome Formation by a Cytosolic Gfp-Chimera✪

Rafael García-Mata;Zsuzsa Bebök;Eric J. Sorscher;Elizabeth S. Sztul.
Journal of Cell Biology (1999)

715 Citations

Regulation of plasma membrane recycling by CFTR

Neil A. Bradbury;Tamas Jilling;Gabor Berta;Eric J. Sorscher.
Science (1992)

402 Citations

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck.
Molecular Biology of the Cell (2016)

399 Citations

Evidence that Systemic Gentamicin Suppresses Premature Stop Mutations in Patients with Cystic Fibrosis

J. P. Clancy;Zsuzsa Bebök;Fadel Ruiz;Chris King.
American Journal of Respiratory and Critical Care Medicine (2001)

302 Citations

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel.
Nature Chemical Biology (2010)

274 Citations

A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

Anjaparavanda P. Naren;Bryan Cobb;Chunying Li;Koushik Roy.
Proceedings of the National Academy of Sciences of the United States of America (2003)

254 Citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

E Weber;G Berta;A Tousson;P St John.
Journal of Cell Biology (1994)

232 Citations

Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.

Sorscher Ej;Peng S;Bebok Z;Allan Pw.
Gene Therapy (1994)

230 Citations

Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.

Ming Du;Julie R. Jones;Jessica Lanier;Kim M. Keeling.
Journal of Molecular Medicine (2002)

210 Citations

Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o– airway epithelial monolayers

Zsuzsa Bebok;James F. Collawn;John Wakefield;William Parker.
The Journal of Physiology (2005)

210 Citations

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