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William E. Balch

William E. Balch

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
48549
World Ranking
892
National Ranking
557

Overview

William E. Balch is affiliated with Scripps Health in the United States and has an extensive research portfolio primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans 39 publications within this main field, with significant contributions specifically in subfields such as Molecular Biology, Genetics, Physiology, Pulmonary and Respiratory Medicine, and Cell Biology.

Balch's research focuses on several main topics including:

  • Protein Structure and Dynamics
  • Bacterial Genetics and Biotechnology
  • Cystic Fibrosis Research Advances
  • Heat Shock Proteins Research
  • Machine Learning in Bioinformatics
  • Single-cell and Spatial Transcriptomics
  • Endoplasmic Reticulum Stress and Disease

Their recent published papers showcase a range of study areas and publication venues. Notable publications include:

  • "The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging," 2021, Journal of Clinical Investigation
  • "Aging is associated with a systemic length-associated transcriptome imbalance," 2022, Nature Aging
  • "Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding," 2020, Diabetes
  • "Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone," 2020, Cell Chemical Biology
  • "Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid," 2020, Journal of Biological Chemistry

Balch has collaborated frequently with several co-authors, including:

  • Chao Wang (13 co-authored publications)
  • Frédéric Anglès (7 co-authored publications)
  • Shuhong Sun (6 co-authored publications)
  • Pei Zhao (4 co-authored publications)
  • Jeffery W. Kelly (4 co-authored publications)

Frequent publication venues for Balch's work include:

  • bioRxiv (Cold Spring Harbor Laboratory) - 3 publications
  • UNC Libraries - 3 publications
  • Diabetes - 2 publications
  • Cell Chemical Biology - 2 publications
  • Communications Biology - 2 publications

Best Publications

  • Methanogens: reevaluation of a unique biological group.

    W E Balch;G E Fox;L J Magrum;C R Woese

  • Adapting proteostasis for disease intervention.

    William E. Balch;Richard I. Morimoto;Andrew Dillin;Jeffery W. Kelly

  • The Phylogeny of Prokaryotes

    GE Fox;E Stackebrandt;RB Hespell;J Gibson

  • Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

    Evan T. Powers;Richard I. Morimoto;Andrew Dillin;Jeffery W. Kelly

  • Functional amyloid--from bacteria to humans.

    Douglas M. Fowler;Atanas V. Koulov;William E. Balch;Jeffery W. Kelly

  • Functional amyloid formation within mammalian tissue

    Douglas M Fowler;Atanas V Koulov;Christelle Alory-Jost;Michael S Marks

  • Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

    Alexander V. Misharin;Luisa Morales-Nebreda;Paul A. Reyfman;Carla M. Cuda

  • Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

    William E. Balch;William G. Dunphy;William A. Braell;James E. Rothman

  • A Di-Acidic Signal Required for Selective Export from the Endoplasmic Reticulum

    Noriyuki Nishimura;William E. Balch

  • Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis

    Xiaodong Wang;John Venable;Paul LaPointe;Darren M. Hutt

  • Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion

    Bernard B. Allan;Bryan D. Moyer;William E. Balch

  • GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.

    Ellen J. Tisdale;Jeffrey R. Bourne;Roya Khosravi-Far;Channing J. Der

  • Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease

    Anu R. Sawkar;Wei-Chieh Cheng;Ernest Beutler;Chi-Huey Wong

  • The organization of endoplasmic reticulum export complexes.

    S I Bannykh;T Rowe;W E Balch

  • Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

    C. Dascher;W.E. Balch

  • Acetobacterium, a New Genus of Hydrogen-Oxidizing, Carbon Dioxide-Reducing, Anaerobic Bacteria

    William E. Balch;S. Schoberth;Ralph S. Tanner;R. S. Wolfe

  • GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

    Claude Nuoffer;William E. Balch

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

    Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  • The Biological and Chemical Basis for Tissue-Selective Amyloid Disease

    Yoshiki Sekijima;R. Luke Wiseman;Jeanne Matteson;Per Hammarström

  • Classification of methanogenic bacteria by 16S ribosomal RNA characterization.

    George E. Fox;Linda J. Magrum;William E. Balch;Ralph S. Wolfe

Frequent Co-Authors

Jeffery W. Kelly
Jeffery W. Kelly Scripps Research Institute
Richard I. Morimoto
Richard I. Morimoto Northwestern University
John R. Yates
John R. Yates Scripps Research Institute
Jacob I. Sznajder
Jacob I. Sznajder Northwestern University
Navdeep S. Chandel
Navdeep S. Chandel Northwestern University
G. R. Scott Budinger
G. R. Scott Budinger Northwestern University
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Karen M. Ridge
Karen M. Ridge Northwestern University
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Ralph S. Wolfe
Ralph S. Wolfe University of Illinois at Urbana-Champaign

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