D-Index & Metrics Best Publications
Biology and Biochemistry
Japan
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 148 Citations 85,732 664 World Ranking 80 National Ranking 3

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary scientific interests are in Cell biology, Biochemistry, Actin cytoskeleton, Adherens junction and Molecular biology. His Cell biology research integrates issues from Nectin and Cadherin. His work in Protein kinase A, G protein, GTP', Binding protein and Protein kinase C are all subfields of Biochemistry research.

His G protein research is multidisciplinary, incorporating perspectives in Small G Protein, GTPase and Cytosol. Yoshimi Takai has included themes like Vinculin, Tight junction, Cell–cell interaction and Cell polarity in his Adherens junction study. His studies deal with areas such as Complementary DNA and cDNA library as well as Molecular biology.

His most cited work include:

  • Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters (4109 citations)
  • Small GTP-Binding Proteins (2119 citations)
  • Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. (1138 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Biochemistry, Nectin, Molecular biology and Adherens junction. While the research belongs to areas of Cell biology, Yoshimi Takai spends his time largely on the problem of Actin cytoskeleton, intersecting his research to questions surrounding Actin. His study in Nectin is interdisciplinary in nature, drawing from both CDC42, Cell junction and Cell polarity.

His Molecular biology study combines topics from a wide range of disciplines, such as Complementary DNA, Cell culture and Peptide sequence. His biological study spans a wide range of topics, including Tight junction and Cell–cell interaction. His Protein kinase A research incorporates elements of Protein kinase C and Diacylglycerol kinase.

He most often published in these fields:

  • Cell biology (61.76%)
  • Biochemistry (38.62%)
  • Nectin (22.25%)

What were the highlights of his more recent work (between 2006-2021)?

  • Cell biology (61.76%)
  • Nectin (22.25%)
  • Cell adhesion molecule (14.58%)

In recent papers he was focusing on the following fields of study:

Yoshimi Takai spends much of his time researching Cell biology, Nectin, Cell adhesion molecule, Adherens junction and Cell adhesion. His Cell biology study incorporates themes from Cadherin, Integrin and Cell junction. His Nectin research incorporates themes from Rap1, Cholinergic neuron, Anatomy and Cell polarity.

His Cell adhesion molecule research is multidisciplinary, relying on both Cell, Cell type, Cell–cell interaction and Cell growth. In his research, RHOA is intimately related to CDC42, which falls under the overarching field of Adherens junction. The subject of his Actin research is within the realm of Biochemistry.

Between 2006 and 2021, his most popular works were:

  • Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation (391 citations)
  • Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease (314 citations)
  • The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. (278 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Yoshimi Takai focuses on Cell biology, Nectin, Cell adhesion, Adherens junction and Cell adhesion molecule. His work carried out in the field of Cell biology brings together such families of science as Cadherin, Integrin and Cell junction. The various areas that Yoshimi Takai examines in his Nectin study include Hippocampus, Desmosome and Cell growth.

His Adherens junction research includes themes of Midbrain, Actin cytoskeleton, Pathology, PI3K/AKT/mTOR pathway and Tight junction. His research in Cell adhesion molecule intersects with topics in Cell, Cell type, Cell–cell interaction, Cellular differentiation and Signal transduction. His DOC2B study is associated with Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters

M Castagna;Y Takai;K Kaibuchi;K Sano.
Journal of Biological Chemistry (1982)

7106 Citations

Small GTP-Binding Proteins

Yoshimi Takai;Takuya Sasaki;Takashi Matozaki.
Physiological Reviews (2001)

3507 Citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

A Kishimoto;Y Takai;T Mori;U Kikkawa.
Journal of Biological Chemistry (1980)

1548 Citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

Y Takai;A Kishimoto;Y Iwasa;Y Kawahara.
Journal of Biological Chemistry (1979)

1408 Citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

M Inoue;A Kishimoto;Y Takai;Y Nishizuka.
Journal of Biological Chemistry (1977)

1170 Citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

Yoshimi Takai;Akira Kishimoto;Ushio Kikkawa;Terutoshi Mori.
Biochemical and Biophysical Research Communications (1979)

866 Citations

Binding of neuroligins to PSD-95

M. Irie;Y. Hata;Y. Hata;M. Takeuchi;M. Takeuchi;K. Ichtchenko;K. Ichtchenko.
Science (1997)

829 Citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

Kenji Takaishi;Takuya Sasaki;Hirokazu Kotani;Hideo Nishioka.
Journal of Cell Biology (1997)

787 Citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

Hiroaki Miki;Takuya Sasaki;Yoshimi Takai;Tadaomi Takenawa.
Nature (1998)

766 Citations

Nectin and afadin: novel organizers of intercellular junctions.

Yoshimi Takai;Hiroyuki Nakanishi.
Journal of Cell Science (2003)

750 Citations

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