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Hiroaki Miki

Hiroaki Miki

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
17224
World Ranking
9067
National Ranking
609

Overview

Hiroaki Miki is affiliated with Osaka University in Japan and focuses research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their scholarly work encompasses several subfields including Molecular Biology, Nutrition and Dietetics, Cell Biology, Oncology, and Nephrology.

Their research expands across a spectrum of key topics, including:

  • Magnesium in Health and Disease
  • Protein Tyrosine Phosphatases
  • Parathyroid Disorders and Treatments
  • Digestive System and Related Health
  • Mechanisms of Cancer Metastasis
  • Microtubule and Mitosis Dynamics
  • Redox Biology and Oxidative Stress

Miki's recent influential papers include:

  • "Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion," published in 2021 in Nature Communications
  • "Control of protein function through oxidation and reduction of persulfidated states," published in 2020 in Science Advances
  • "Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter," published in 2021 in Science Advances
  • "Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress," published in 2020 in Science Advances
  • "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis," published in 2020 in Developmental Cell

Frequent co-authors collaborating with Miki include:

  • Yosuke Funato
  • Osamu Hashizume
  • Daisuke Yamazaki
  • Yichen Huang
  • Motoyuki Hattori

Publication venues favored by Miki feature:

  • Science Advances
  • Nature Communications
  • Scientific Reports
  • British Journal of Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

    Rajat Rohatgi;Le Ma;Hiroaki Miki;Marco Lopez

  • WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac

    Hiroaki Miki;Shiro Suetsugu;Tadaomi Takenawa

  • Molecular mechanisms of invadopodium formation the role of the N-WASP–Arp2/3 complex pathway and cofilin

    Hideki Yamaguchi;Mike Lorenz;Stephan Kempiak;Corina Sarmiento

  • Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

    Hiroaki Miki;Takuya Sasaki;Yoshimi Takai;Tadaomi Takenawa

  • N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

    H. Miki;K. Miura;T. Takenawa

  • WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement

    T. Takenawa;H. Miki

  • IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

    Hiroaki Miki;Hideki Yamaguchi;Shiro Suetsugu;Tadaomi Takenawa

  • The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-β-catenin signalling through Dishevelled

    Yosuke Funato;Tatsuo Michiue;Makoto Asashima;Hiroaki Miki;Hiroaki Miki

  • WIP regulates N-WASP-mediated actin polymerization and filopodium formation

    Narcisa Martinez-Quiles;Rajat Rohatgi;Inés M. Antón;Miguel Medina

  • Identification of Two Human WAVE/SCAR Homologues as General Actin Regulatory Molecules Which Associate with the Arp2/3 Complex☆

    Shiro Suetsugu;Hiroaki Miki;Tadaomi Takenawa

  • The essential role of profilin in the assembly of actin for microspike formation

    Shiro Suetsugu;Hiroaki Miki;Tadaomi Takenawa

  • Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

    Kiyohito Mizutani;Hiroaki Miki;Hong He;Hiroshi Maruta

  • Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri.

    Toshihiko Suzuki;Hiroaki Miki;Tadaomi Takenawa;Chihiro Sasakawa

  • WAVE2 is required for directed cell migration and cardiovascular development

    Daisuke Yamazaki;Shiro Suetsugu;Hiroaki Miki;Hiroaki Miki;Yuki Kataoka

  • Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species.

    Hiroaki Miki;Yosuke Funato

  • Regulation of actin dynamics by WASP family proteins.

    Hiroaki Miki;Tadaomi Takenawa

  • Sustained Activation of N-WASP through Phosphorylation Is Essential for Neurite Extension

    Shiro Suetsugu;Mitsuharu Hattori;Hiroaki Miki;Tohru Tezuka

  • A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42.

    Maiko Fukuoka;Shiro Suetsugu;Hiroaki Miki;Kiyoko Fukami

  • Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization.

    Hiroaki Miki;Tadaomi Takenawa

  • Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts.

    Suzie Verma;Annette M. Shewan;Jeanie A. Scott;Falak M. Helwani

Frequent Co-Authors

Tadaomi Takenawa
Tadaomi Takenawa Kobe University
Shiro Suetsugu
Shiro Suetsugu Nara Institute of Science and Technology
Hideki Yamaguchi
Hideki Yamaguchi Sasaki Institute
Chihiro Sasakawa
Chihiro Sasakawa Chiba University
Kalle Gehring
Kalle Gehring McGill University
Yoshimi Takai
Yoshimi Takai Kobe University
Shigeaki Nonoyama
Shigeaki Nonoyama National Defense Medical College
Shun Shimohama
Shun Shimohama Sapporo Medical University
Nobuaki Yoshida
Nobuaki Yoshida University of Tokyo
Hitomi Mimuro
Hitomi Mimuro Osaka University

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