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Kalle Gehring

Kalle Gehring

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
15031
World Ranking
7492
National Ranking
259

Overview

Kalle Gehring is affiliated with McGill University in Canada and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields including molecular biology, neurology, epidemiology, nutrition and dietetics, and plant science.

The scientist's work focuses on a variety of topics, such as:

  • Parkinson's Disease Mechanisms and Treatments
  • Autophagy in Disease and Therapy
  • Ubiquitin and proteasome pathways
  • RNA and protein synthesis mechanisms
  • Magnesium in Health and Disease
  • Protein Tyrosine Phosphatases
  • Mitochondrial Function and Pathology

Among recent publications, some notable papers include:

  • Calnexin cycle - structural features of the ER chaperone system (2020, FEBS Journal)
  • Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin (2023, Journal of Molecular Biology)
  • Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons (2023, Neuron)
  • LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization (2021, RNA Biology)
  • Crystal structure of an archaeal CorB magnesium transporter (2021, Nature Communications)

Gehring has collaborated frequently with several coauthors, including:

  • Guennadi Kozlov
  • Véronique Sauvé
  • Rayan Fakih
  • Yu Seby Chen
  • Jianning Jiang

The primary publication venues where Gehring's research appears the most are:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • RNA Biology
  • FEBS Journal

Gehring's scholarly output shows a significant focus on molecular mechanisms underlying neurological conditions such as Parkinson's disease, as well as broader biochemical pathways including protein chaperone systems, mitochondrial quality control, and magnesium transport. This research integrates molecular biology techniques with investigations into cellular and neurological health.

Best Publications

  • A tetrameric DNA structure with protonated cytosine.cytosine base pairs

    Kalle Gehring;Jean-Louis Leroy;Maurice Guéron

  • Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

    Jean François Trempe;Véronique Sauvé;Karl Grenier;Marjan Seirafi

  • Structural proteomics of an archaeon.

    Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger

  • Protein quality control in the ER: The recognition of misfolded proteins

    Pekka Määttänen;Kalle Gehring;John J.M. Bergeron;David Y. Thomas

  • The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.

    Tudor Moldoveanu;Qian Liu;Ante Tocilj;Mark Watson

  • A structural overview of the PDI family of proteins.

    Guennadi Kozlov;Pekka Määttänen;David Y. Thomas;Kalle Gehring

  • Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

    Guennadi Kozlov;Jean-François Trempe;Kianoush Khaleghpour;Avak Kahvejian

  • An NMR approach to structural proteomics.

    Adelinda Yee;Xiaoqing Chang;Antonio Pineda-Lucena;Bin Wu

  • Acid multimers of oligodeoxycytidine strands: stoichiometry, base-pair characterization, and proton exchange properties.

    Jean Louis Leroy;Kalle Gehring;Abdelali Kettani;Maurice Gueron

  • Parkin structure and function

    Marjan Seirafi;Guennadi Kozlov;Kalle Gehring

  • BID-induced structural changes in BAK promote apoptosis.

    Tudor Moldoveanu;Christy R Grace;Fabien Llambi;Amanda Nourse

  • A Ubl/ubiquitin switch in the activation of Parkin

    Véronique Sauvé;Asparouh Lilov;Marjan Seirafi;Marta Vranas

  • Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

    Martine Girard;Roxanne Larivière;David A. Parfitt;Emily C. Deane

  • Solution NMR Studies of a 42 KDa Escherichia Coli Maltose Binding Protein/β-Cyclodextrin Complex: Chemical Shift Assignments and Analysis

    Kevin H. Gardner;Xiaochen Zhang;Kalle Gehring;Lewis E. Kay

  • Structural architecture of an outer membrane channel as determined by electron crystallography.

    B. K. Jap;P. J. Walian;K. Gehring

  • Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.

    Tudor Moldoveanu;Kalle Gehring;Douglas R. Green

  • Structural Basis of Carbohydrate Recognition by Calreticulin

    Guennadi Kozlov;Cosmin L. Pocanschi;Angelika Rosenauer;Sara Bastos-Aristizabal

  • Crystal Structure of the bb′ Domains of the Protein Disulfide Isomerase ERp57

    Guennadi Kozlov;Pekka Maattanen;Joseph D. Schrag;Stephanie Pollock

  • Development of pharmacological agents for targeting neurotrophins and their receptors.

    H.Uri Saragovi;Kalle Gehring

  • Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance.

    Tatiana Domitrovic;Guennadi Kozlov;João Claudio Gonçalves Freire;Claudio Akio Masuda

Frequent Co-Authors

Peter S. McPherson
Peter S. McPherson Montreal Neurological Institute and Hospital
Miroslaw Cygler
Miroslaw Cygler University of Saskatchewan
David Y. Thomas
David Y. Thomas McGill University
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Bernard Brais
Bernard Brais Montreal Neurological Institute and Hospital
Masad J. Damha
Masad J. Damha McGill University
Hiroshi Nikaido
Hiroshi Nikaido University of California, Berkeley
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Lawrence P. McIntosh
Lawrence P. McIntosh University of British Columbia
Hiroaki Miki
Hiroaki Miki Osaka University

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